DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abcc5

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_001182542.1	Gene:	abcc5 / 336147	ZFINID:	ZDB-GENE-050517-17	Length:	1426	Species:	Danio rerio

Alignment Length:	1397	Identity:	464/1397 - (33%)
Similarity:	731/1397 - (52%)	Gaps:	139/1397 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ENPREKSNIFSSLMFCFAMPTFFKGRKK-TLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRK 74
            ::|.:.:.:||.:.|.:.........|| .|...|::...|....:....:|:..||:|:..:..
Zfish    93 QHPVDNAGLFSFMTFNWLTSLAVLAHKKGQLFLEDIWAVSQFESCEINRRRLAGLWEEEIRSRGN 157

  Fly    75 KKKTPSLLKASMNVFGWRLAGLGLVLFILEI------GFRVTQPLFLGGLVAYYADASNQEGDNQ 133
                    .||:....|......|:|.||.:      ||  :.|.|:...:..|...|..:   .
Zfish   158 --------DASLRRVVWHFCRTRLLLSILCLMVTQLAGF--SSPAFVVWRLLEYTQRSEPD---L 209

  Fly   134 TKAYLYALGVI-----------LTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTA 187
            ....|..||::           ||.|.|           :..|.:.|.|:.:|.:.|.|||  .:
Zfish   210 PYGLLLVLGLLATELIRSWSHALTWALN-----------YRTGTRLRGAILTMAFHKILRL--RS 261

  Fly   188 LGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGP-VEIGIITYLMYREIGISAFFGVAVMLLFIP 251
            |.:.::|:::|:.|.|..|:..:....:.|..|| |.:..:.|.:: .:|.::..|.||.:||.|
Zfish   262 LREKSMGELINMCSGDGQRMFEAAAVGSLLAGGPLVAVLGMAYNLF-VLGPTSLLGSAVFILFYP 325

  Fly   252 LQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVN 316
            ...:..:.|:..|.|....||:||:.||||::.|:.||||||...||:.:..:|.:|...:....
Zfish   326 TMMFSSRLTAYFRRKGVAVTDQRVQKMNEILNYIKFIKMYAWVKAFSQAVRRIRDEERQILERTG 390

  Fly   317 YIRGTLQSFIMFVTRISVFVSLVG----FVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQ 377
            |    .||..:.|..|.|.::.|.    .:|||..|||.:||.:...:|.:...:.| .|..:..
Zfish   391 Y----FQSITVGVAPIVVVIASVATFSTHMLLGYDLTAAQAFTVVTVFNAMTFALKV-TPFSVKS 450

  Fly   378 FAELLVSIRRIQTFMLHEETKV-----RDKSEDLDEQKLGKA----GLIAEPTV-----AQTTGV 428
            .:|..|:|.|.::.:|..|.|:     |:.|..::......|    |..|:|:.     ..|.|.
Zfish   451 LSEASVAIDRFKSLLLMAEVKMIRELPRNPSVAVEMSGASLAWETGGHSAQPSPRGTPHVGTRGC 515

  Fly   429 LKPSSRRTSEAEHSIVISKLKAKW-------------DQ--------KNTDNTLDNISLKFKPRQ 472
            .|...:|.....|:|:..:...:.             ||        :....||..|.|..:..:
Zfish   516 RKKRRQRDVPKHHAILEEETHGQLLNDVSGEMASSPKDQTLHVPTISQRLQRTLHCIDLSIQKGK 580

  Fly   473 LVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRY 537
            ||.|.|.|||||:|||.|:||::....|:|.|:|..:|.:|:.|:...:.|.|||||..|::.||
Zfish   581 LVGVCGSVGSGKTSLISAILGQMTLLEGTVAVDGDFAYVAQQAWILNASFRDNILFGKEMEEERY 645

  Fly   538 RTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHV 602
            :.::..|.|..|..:||..|.|.:|||||:|||||:.|||||||:|....||:|||||||:|.||
Zfish   646 QAILSACCLRPDLAMLPSGDLTEIGERGANLSGGQRQRISLARALYSNRGIYILDDPLSALDAHV 710

  Fly   603 GRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDP 667
            |.|:|:..::..||.:.|:.||||||:|...|.:::|..|.|:..|::|.:.....|:|.|..:.
Zfish   711 GNHIFNNAIKKQLRGKTVIFVTHQLQYLVDCDDVIVMRDGSIAEQGSHEDLMNVNGDYAAMFNNL 775

  Fly   668 SKKDEGAGDAPDKKSLSRQNSKL-RDRHGSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKK 731
            ...:....:.|:|||.|.....| :.:.||:...:|..:   .:..:...|.|.:|.:...:||.
Zfish   776 QLGETPIIEVPNKKSGSSLKKPLEKSKAGSVKKEKSTTQ---GDGQLMQVEERGKGSVPWAVYKV 837

  Fly   732 YFGA-NGYGLFIVFAFFCIGAQVLASGGDIF----LSYWVNKNGEAERDTFMARLRRAFPETRIN 791
            |..| .|:.:|:    |.:...:|..|...|    |.||: |.|.......:..........|.|
Zfish   838 YIQALGGWPVFL----FILALFILNVGSTAFSNWWLCYWI-KQGSGNTTVQVGNSSVLSESMRDN 897

  Fly   792 ADTDPVDIYYFTGINVS---VIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSG 853
                |:..:|.....:|   :::..|:|.::|....:|:|:.||:.:||.:.|:.|.||:|.|:.
Zfish   898 ----PLMQHYAAVYTMSMGVMLLLKLLRGIVFVKGTLRASSRLHDELFQKILRSPMKFFDTTPTA 958

  Fly   854 RILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLS 918
            |||||||||:.:||..||.......|..:.::..:.|:..:..|:::|...||::|.:|.|....
Zfish   959 RILNRFSKDMDEVDTRLPFQAEMFTQNVILVLFCLAVIGSVFPWFLVAVGPLVLLFTVLHVVSRV 1023

  Fly   919 TSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFG 983
            ..|::|||:.||:||..||:::|:.||.|:.|:|.:.|.:..:....|.:.:.:|:|....|...
Zfish  1024 FIRELKRLDNVTQSPFLSHIASSIQGLTTVHAYGKEDEFLHRYQELLDQNQAPFYLFSCAMRWLA 1088

  Fly   984 YWLDCVCVVYIAVITLSFFLFSPENGGDV-----GLAITQAMGMTGMVQWGMRQSAELENTMTAV 1043
            ..||.:.|..|::..|...|..    |.:     ||||:.|:.:||:.|:.:|.::|.|...|:|
Zfish  1089 VRLDVISVALISITALMIVLMH----GQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSV 1149

  Fly  1044 ERVVEY-EDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEK 1107
            ||:..| :.|..|.....| ||.||.|||::|:||||...:||..:  ...:|:..:..:...||
Zfish  1150 ERIHHYIKSLSLEAPARVK-NKAPPSDWPQEGEIVFDQTEMKYRDN--LPLILKKASFTVRPKEK 1211

  Fly  1108 VGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYN 1171
            :|||||||:|||||...|:|| ....|:|.||..:..|:||.|:|||:|||||||||||||:|.|
Zfish  1212 IGIVGRTGSGKSSLGVVLYRLVEPCGGSIKIDGVNICDIGLADVRSKLSIIPQEPVLFSGTVRSN 1276

  Fly  1172 LDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILV 1236
            ||||.:||:|::|::||...:|:.|:.||..|:|::.|.|.|||||:|||:|:||.:||:.:||:
Zfish  1277 LDPFSQYSEAQIWDALERTHMKECVSQLPLKLESEVVENGENFSVGERQLLCVARVLLRQCKILI 1341

  Fly  1237 MDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTT 1301
            :|||||.:..:||.|||.||||.|:|||.||||||:|||:..|:::|::.|:.|||..|.:||..
Zfish  1342 LDEATAAMGTETDCLIQETIRNAFQDCTTLTIAHRVHTVLSCDRIMVLNQGQVVEFDEPSKLLAN 1406

  Fly  1302 SEKKVFHSMVKQTGDSTFDALL-KVAQKVGLR 1332
            .             :|.|.|:| .|..|:.:|
Zfish  1407 E-------------NSRFCAMLAAVENKISVR 1425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	456/1361 (34%)
		ABC_membrane	98..367	CDD:294371	81/290 (28%)
		ABCC_MRP_domain1	443..643	CDD:213217	90/220 (41%)
		ABC_membrane	799..1027	CDD:294371	74/235 (31%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	117/221 (53%)
abcc5	NP_001182542.1	intraplasmic N-terminal	1..59
		transmembrane domain 1	59..149		10/55 (18%)
		CFTR_protein	95..1419	CDD:273530	461/1387 (33%)
		ABC_membrane	177..441	CDD:294371	79/286 (28%)
		nucleotide binding domain 1	188..248		14/75 (19%)
		transmembrane domain 2	279..379		33/100 (33%)
		nucleotide binding domain 2	403..450		13/47 (28%)
		ABCC_MRP_domain1	552..751	CDD:213217	89/198 (45%)
		ABC_membrane	851..1132	CDD:294371	85/289 (29%)
		ABCC_MRP_domain2	1180..1400	CDD:213211	117/221 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585980
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.660