DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and Pmp70

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_001259732.1	Gene:	Pmp70 / 32992	FlyBaseID:	FBgn0031069	Length:	665	Species:	Drosophila melanogaster

Alignment Length:	680	Identity:	166/680 - (24%)
Similarity:	271/680 - (39%)	Gaps:	148/680 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 AWEKEVEKKRK------------KKKTPSLLKASMN-VFGWRLAGLGLVL----FILEIG--FRV 109
            |:.|...||||            :||.....||.:| ||..:|..|..:|    :.:|.|  |.|
  Fly    29 AYGKMSNKKRKPGYEDKIQYTIAEKKDKKAGKAHVNSVFFKQLRQLLPILIPGFWSVETGLLFLV 93

  Fly   110 TQPLFLGGLVA---YYADASNQEGD----NQTK------AYLYALGVILTSACNVLFMHPYMLGM 161
            ...| :|..|:   ...:|:..|..    |:||      .||.||..| :...|||   .:.||
  Fly    94 AAAL-IGRSVSDIWMIQNATVVESTIIHMNRTKFKTALLKYLTALPAI-SVVTNVL---KWSLG- 152

  Fly   162 FHIGMKARIAMTSMIYRKAL------RLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLG 220
             .:.::.|..:|..:|.:.|      ::|..   |..|.....|::.|:.:...|...:......
  Fly   153 -ELKLRFRTNLTHHLYSQYLNGYTYYKMSNL---DNRIANADQLLTTDIDKFCESATDLYSNISK 213

  Fly   221 PV-EIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNE---- 280
            || :|.|..|.:...:|...   .::::|::   .:.|...:.||..|...|.|..::..|
  Fly   214 PVLDIFIYVYRLTVNLGGKT---PSILMLYL---LFAGVFLTRLRRPTGRLTVEEQKLEGEFRYV 272

  Fly   281 ---IISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISV-------- 334
               :|:..:.:..|...:          .:::..:.:.:.:|..|:.|:.|  |:|:
  Fly   273 NSRLITNSEEVAFYQGNV----------REKLTLLASYSKLRSHLRKFLEF--RVSMGIIDNIIG 325

  Fly   335 --FVSLVGFVLLG--------KLLTAEKAFV-ITAYYNILRNTMTVYFPMGISQFAELLVSIRRI 388
              |.|:|||..:.        .||:.|.:.. :.|||...|..:.:...:|     .|:::.|.:
  Fly   326 KYFASIVGFYAVSIPFFSENHPLLSGENSGQRLQAYYTYGRMLVKLAEAIG-----RLVLAGREM 385

  Fly   389 Q-----TFMLHEETKV-RDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISK 447
            .     |..:.|..|| .|.::...|:.:.....:|:..|...:....|:.......::.|...|
  Fly   386 SRLAGFTARMTELIKVLSDLNKGTYERTMVNGNNLAQNAVGSASSNFGPNKGIMCFEDNIIRFEK 450

  Fly   448 LKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKV----NGTL 508
            :...  ..|.|..|..:|.:.|....|.|.||.|.|||||.: :||||.|..|. ||    .|.|
  Fly   451 VPLV--TPNGDVLLQELSFEVKSGTNVLVCGPNGCGKSSLFR-ILGELWPTWGG-KVTKPSRGKL 511

  Fly   509 SYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIV-------GERGA 566
            .|..|.|::..||:|..|::....|.      ::|.. ..|.:|:.|.|  ||       .|.|.
  Fly   512 FYVPQRPYMTLGTLRDQIIYPHTRDD------MRRLG-HSDEDLMHYLD--IVQLTYLEQRENGL 567

  Fly   567 S--------LSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLL- 622
            .        ||||:|.||::||..|.|....:||:..|||...|...::..|     ||..:.|
  Fly   568 DSIEDWIDVLSGGEKQRIAMARLFYHKPQFAILDECTSAVSVDVEGKMYSYC-----REVGITLF 627

  Fly   623 -VTHQLQFLEQADVIVIMDKGKISAMGTYE 651
             |:|:.......|..:..|     ..|:||
  Fly   628 TVSHRKSLWAHHDYYLQFD-----GRGSYE 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	166/680 (24%)
		ABC_membrane	98..367	CDD:294371	67/320 (21%)
		ABCC_MRP_domain1	443..643	CDD:213217	69/220 (31%)
		ABC_membrane	799..1027	CDD:294371
		ABCC_MRP_domain2	1074..1295	CDD:213211
Pmp70	NP_001259732.1	3a01203	3..653	CDD:273360	166/680 (24%)
		ABC_membrane_2	63..342	CDD:284003	65/306 (21%)
		ABCD_peroxisomal_ALDP	446..651	CDD:213190	70/227 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910