DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abcc3

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_009304645.1	Gene:	abcc3 / 323301	ZFINID:	ZDB-GENE-050517-16	Length:	1540	Species:	Danio rerio

Alignment Length:	1419	Identity:	496/1419 - (34%)
Similarity:	763/1419 - (53%)	Gaps:	200/1419 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKE--------- 68
            |...:...|.:.|.:......||.|..|:..||:...:...|:.:...|...||.|
Zfish   204 PETTAGFLSRMTFWWFTRMAIKGYKSPLENKDLWSLNKNDSSELVVPGLLNQWEVEKSKAHSSDD 268

  Fly    69 -------------------------------VEKKRKKKKTPSLLKASMNVFGWRLAGLGLVLFI 102
                                           :.|:::|.:.||.|.|.:..||        ..|:
Zfish   269 QNVKEQVTFTKPGSGAESNHVNESPEEAEVLLSKQQQKSRQPSFLWALLRAFG--------PYFL 325

  Fly   103 LEIGFRVTQ-------PLFLGGLVAY--YADASNQEGDNQTKAYLYALGVIL--TSACNVLFMHP 156
            :...|::.|       |..|..|:|:  .:|..:..|        |||..::  ||....|.:|.
Zfish   326 IGSAFKLLQDLITFINPQLLRMLIAFTKQSDVPSWWG--------YALAFLMFGTSLLQTLILHQ 382

  Fly   157 YMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGP 221
            :....|..||:.|..:...||||||.::..|...:|:|:||||:|.|..|.......:|.||..|
Zfish   383 HFQYCFVTGMRLRTGIIGAIYRKALVITNEAKRSSTVGEVVNLMSVDAQRFMDLTTFLNMLWSAP 447

  Fly   222 VEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQ 286
            ::|.:..:.:::.:|.|...|||||:|.||..|::..||...:::.....|:|:::||||::||:
Zfish   448 LQIFLALFFLWQNLGPSVLAGVAVMVLLIPFNAFIAMKTRTYQVEQMKYKDDRIKLMNEILNGIK 512

  Fly   287 VIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRG------TLQSFIMFVTRISVFVSLVGFVLLG 345
            |:|:||||..|...|..:|.||::.:|...|:..      |...|::.:|..:|||:    |...
Zfish   513 VLKLYAWEPSFRDKILQIRQKELHVLRKTAYLSALSTMAWTSAPFLVALTSFAVFVN----VDEK 573

  Fly   346 KLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQK 410
            .:|.||||||..:.:||||..:.: .|..||...:..||::|:|.|:.|:|         ||.:.
Zfish   574 NVLDAEKAFVSLSLFNILRFPLNM-LPQVISSIVQASVSLKRLQDFLNHDE---------LDPES 628

  Fly   411 LGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVA 475
            :                     .|:::..|:::.:...|..| .|.....||||::......|:|
Zfish   629 V---------------------DRKSNTTEYAVSVVNGKFSW-AKRDQVILDNINVLVPQGSLLA 671

  Fly   476 VIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTV 540
            |:|.||.||:|||.|:|||:....|.:.:.|:::|..|:.|:...|:|.|||||.|..:.:||.|
Zfish   672 VVGHVGCGKTSLISALLGEMEKLDGQISIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCV 736

  Fly   541 VKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRH 605
            ::.|||..|.|:||..|.|.:||:|.:|||||:.|:|||||:|.:||:|||||||||||.||.:|
Zfish   737 LEACALTPDLEVLPGGDLTEIGEKGINLSGGQRQRVSLARALYSEADVYLLDDPLSAVDAHVAKH 801

  Fly   606 LFDQCM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPS 668
            :||..:  .|.|:.:..:||||.:.||.|.:.|:::..|::|.||:|:.:.:....||:.|.:.|
Zfish   802 IFDHVIGPEGALKGKTRILVTHGISFLPQVNNILVLVDGRVSEMGSYQDLLRQNGAFAEFLRNYS 866

  Fly   669 KK------------DEGAGDAPD-------------------KKSLSRQNSKLR---DRHGSISS 699
            .:            ||...:.|:                   ::...||.|.:.   :....:|.
Zfish   867 LEDIIEDDELTVSFDEEEEEFPEDALSNHTDMVDNEPVVNEARRQFMRQMSIMSNDVENPKKMSR 931

  Fly   700 MESAAESLAAESPMQTQEGRVE----------GRIGMKLYKKYFGANG--YGLFIVFAFFCIGAQ 752
            ....:|....|:|.:.:|.:||          ||:.:::|.:|..|.|  ..|||.|.:.|..|
Zfish   932 RRRCSERKHPETPTEKKEPKVEKLIQAETTETGRVKLQVYWEYVKAIGPLLALFICFLYGCQSA- 995

  Fly   753 VLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFS---L 814
             .|.|.:.:||.|.|       |....|.:... :||       |.:|...||:..|:|.|   |
Zfish   996 -AAIGANFWLSEWTN-------DALHNRTQEML-QTR-------VGVYAALGISQGVLILSICLL 1044

  Fly   815 VRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQ 879
            .|:    |..:|::...|..|...|.||...||...||||:|||||||:..:|.::|..:...|:
Zfish  1045 CRA----YSTLRAARHTHQHMLNSVLRAPQAFFEATPSGRVLNRFSKDVDTIDSLIPDNIDIWMR 1105

  Fly   880 IFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNG 944
            .|...|.:::|..::...:::..|.|::.::.::.||::|||.:||||:|:|||||||.|.|:.|
Zfish  1106 TFWYTVNVLMVCSVLTPIFLIVIVPLMLFYWWVQRFYVATSRQLKRLESVSRSPIYSHFSESITG 1170

  Fly   945 LATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCV--CVVYIAVITLSFFL---- 1003
            .:.|||:|.....:...||..|.:...||..:.::|..|..::.:  |:|..|.:   |.:
Zfish  1171 TSVIRAYGRNAAFVLMSDNKVDENQKSYYPGIVSNRWLGVRIEFIGNCIVLFAAL---FAVTGKD 1232

  Fly  1004 -FSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPP 1067
             .||   |.|||:::.|:.:|..:.|.:|.:::||:.:.|||||.||.:.:.|..:|.. .||||
Zfish  1233 KLSP---GLVGLSVSYALQVTMSLNWMVRMTSDLESNIVAVERVKEYSETQTEAPWEVL-EKKPP 1293

  Fly  1068 KDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFR-LSYN 1131
            .|||..|.:.|.|.|::|  .:..|.||:::::.:.|.||:||||||||||||:...||| |...
Zfish  1294 PDWPPLGNVEFVDYSVRY--REGLDLVLKNISLKVRGGEKIGIVGRTGAGKSSMTLCLFRLLEAA 1356

  Fly  1132 EGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVV 1196
            .|.|:||....:::||||||||::||||||||||||:|.|||||:.|||.::|::||...|::.|
Zfish  1357 AGEIVIDDVKISEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFERYSDEEVWKALELSHLQKFV 1421

  Fly  1197 ADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFK 1261
            .:..:.|:.:.||||.|.|||||||||||||:||:.||||:|||||.||.:||.|||:|||.:|:
Zfish  1422 TNQAAKLELECSEGGENLSVGQRQLVCLARALLRKTRILVLDEATAAVDLETDDLIQSTIRTEFQ 1486

  Fly  1262 DCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            ||||.||||||:|:||..:|||:|.|:..||.:|..|:  ::|.:|..|.|..|
Zfish  1487 DCTVFTIAHRLNTIMDYTRVLVLDKGQIAEFDTPTNLM--NQKGLFFGMAKDAG 1538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	491/1402 (35%)
		ABC_membrane	98..367	CDD:294371	93/285 (33%)
		ABCC_MRP_domain1	443..643	CDD:213217	90/201 (45%)
		ABC_membrane	799..1027	CDD:294371	79/237 (33%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	126/221 (57%)
abcc3	XP_009304645.1	MRP_assoc_pro	10..1539	CDD:188098	496/1419 (35%)
		ABC_membrane	330..595	CDD:279056	92/276 (33%)
		ABCC_MRP_domain1	640..841	CDD:213217	90/201 (45%)
		ABC_membrane	985..1253	CDD:279056	95/294 (32%)
		ABCC_MRP_domain2	1300..1520	CDD:213211	126/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586010
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.760