DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and Abcc10

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_001101671.1	Gene:	Abcc10 / 316231	RGDID:	1306696	Length:	1494	Species:	Rattus norvegicus

Alignment Length:	1366	Identity:	435/1366 - (31%)
Similarity:	689/1366 - (50%)	Gaps:	174/1366 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SSLMFCFAMPTFFKG-RKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKKKKTPSLLKA 84
            |...:.:..|...:| |.:.....|..|..:.....:|.....|.|          |:...|.:|
  Rat   223 SRFSYAWLAPLLARGVRGELRQPQDTCRLPRRLHPAYLARAFQAHW----------KEGAQLWRA 277

  Fly    85 SMNVFGWRLAGLGLVLFI-LEIGFRVTQPLFLGGLVAYYADASNQEGDNQ-TKAYLYALGVILTS 147
            ....||.....|||:..: ..:||  :.||.|..||.:.     :||... :...||.||:...|
  Rat   278 LYGAFGCCYIALGLLKMVGTMLGF--SGPLLLSLLVGFL-----EEGQEPLSHGLLYVLGLASGS 335

  Fly   148 ACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVI 212
            ..:.:..:.|...:..:.::||:|:.|::|||.|:|..:.   ...|:|:||:..|..||
  Rat   336 VISAVLQNQYGYEVRKVTLQARVAVLSILYRKTLKLGPSR---PPTGEVLNLLGTDSERL----- 392

  Fly   213 HMNY------LWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRT 271
             :|:      .|..|:::.|..||:|.::|::...|:.:.||.:|:...:..:......:.....
  Rat   393 -LNFAGSFHEAWGLPLQLAITLYLLYEQVGVAFLAGLVLALLLVPVNKVIATRIMANNQEMLRHK 456

  Fly   272 DERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGT---LQSFIMFVTRIS 333
            |.||::|.|::|||:|:|.:.||......:...||:|:..:|.:.|:...   |.:.:..|..|.
  Rat   457 DARVKLMTELLSGIRVLKFFRWEQALGDRVKACRTQELGRLRVIKYLDAACVYLWAALPVVICIV 521

  Fly   334 VFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETK 398
            :|::   :||||..|||.|.|...|..::|...:. .||..|:...|..||:.|||.|:
  Rat   522 IFIT---YVLLGHQLTATKVFTALALVHMLILPLN-NFPWVINGLLESKVSLDRIQRFL------ 576

  Fly   399 VRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDN 463
                  ||.... .:|....:|          |:...|....|..:.|     ||...|......
  Rat   577 ------DLPSYS-PEAYYSPDP----------PTEPSTVLELHEALFS-----WDPTGTSQKTFI 619

  Fly   464 ISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGT---LSYASQEPWLFTGTVRQN 525
            ..|:.|...||.::|.||.|||||:.|:.|||:...|.|.|:..   ...|:||||:...|:|.|
  Rat   620 SHLQVKKGMLVGIVGKVGCGKSSLLAAITGELHRLCGWVAVSDLSKGFGLATQEPWIQCATIRDN 684

  Fly   526 ILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYL 590
            :|||...|...||.|::.|||..|..:||..|:|.|||:|.:|||||:|||:||||||::..:||
  Rat   685 VLFGKTFDAQLYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKTLYL 749

  Fly   591 LDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESM-- 653
            |||||:|||..|..||..:|:.|.|.....||.||:.::||:||::::|:.|::...|....:
  Rat   750 LDDPLAAVDADVANHLLHRCILGVLGHTTRLLCTHRTEYLERADLVLLMEAGRLVRAGPPSEILP 814

  Fly   654 ----AKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAAESL-AAESP- 712
                |.:.|...:.:||       :|.:|                 |:.::|...|.| .|::.
  Rat   815 LVQAAPTALADKEQVTD-------SGQSP-----------------SVHNLEKTTEELDVAQNTS 855

  Fly   713 --MQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVN-----KNG 770
              :..:|.:.||.:.:.:|:.|:.|.|.||........:..|...:|.|.:|::|::     :|.
  Rat   856 GRLVQEESKSEGAVALHVYRAYWRAMGSGLATAILISLLLMQATRNGADWWLAHWLSQLKAGRNS 920

  Fly   771 EAERDT---------FMARLRRAFP--------ETRINADTDPVDIY---YFT--GINVSVIIFS 813
            ..||..         |..||....|        :...|..:| |..|   |.|  |:|   .:.:
  Rat   921 SEERPASSSPRSMGFFSPRLLLFSPGNLYIPLHKATSNGSSD-VHFYLTVYATIAGVN---SLCT 981

  Fly   814 LVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVM 878
            |:|::||...|::::.:||:.:...:..|.:.|:::.||||:|||||.|:..||:.||.::..::
  Rat   982 LLRAVLFAAGALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNILL 1046

  Fly   879 QIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLN 943
            ...:.::|::.||.....|.:|....|..::|.::..|.::.|:::||.::|.||:||||:.:|.
  Rat  1047 ANSVGLLGLLAVLGSGLPWLLLLLPPLSFIYYGVQRRYRASFRELRRLGSLTLSPLYSHLADTLA 1111

  Fly   944 GLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLD-------CVCVVYIAVITLSF 1001
            ||..:||.||......|.....:::....:...||.:    |||       ...|..||.|.|..
  Rat  1112 GLPVLRAAGATYRFEEENQRLLELNQRCQFASYATMQ----WLDIRLQLMGAAVVSAIAGIALVQ 1172

  Fly  1002 FLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKP 1066
            ......|.|.|||.::.|:.:||::...:....:.|..|.:|||:.||     ..|...:|:.:|
  Rat  1173 HQQGLANPGLVGLVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEY-----SCDIPQEPHGQP 1232

  Fly  1067 PK------DWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINAL 1125
            |:      .|...|.:.|.|:.|.|.|  .....|..:...:|..||:|||||||:|||||...|
  Rat  1233 PQSPHQRVSWLTQGSVEFQDVVLVYRP--GLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVL 1295

  Fly  1126 FR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEE 1189
            || |..:.|.:|:|..||:.|.|.:|||::::|||||.|||||:|.||||...:.|..||::||:
  Rat  1296 FRLLEPSAGQVLLDGVDTSQLELAELRSQLAVIPQEPFLFSGTVRENLDPQGLHEDRALWQALEQ 1360

  Fly  1190 VKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQT 1254
            ..|.:|...: .||..::.|.|.:.|:|||||:|||||:|.:.:||.:|||||:||.:||.|:|.
  Rat  1361 CHLSEVAMAI-GGLDGELGERGRDLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQ 1424

  Fly  1255 TIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSP----------FELLTTSEKKVFHS 1309
            ||..:|.:.|||||||||:|:::||:|||:.||:.||..||          |..|..|.::..||
  Rat  1425 TICRRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSALRNQPHSLFRQLLQSSQQGAHS 1489

  Fly  1310 M 1310
            :
  Rat  1490 L 1490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	431/1354 (32%)
		ABC_membrane	98..367	CDD:294371	76/279 (27%)
		ABCC_MRP_domain1	443..643	CDD:213217	89/202 (44%)
		ABC_membrane	799..1027	CDD:294371	72/239 (30%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	109/221 (49%)
Abcc10	NP_001101671.1	CFTR_protein	211..1485	CDD:273530	433/1359 (32%)
		ABC_membrane	290..552	CDD:294371	77/280 (28%)
		ABCC_MRP_domain1	599..802	CDD:213217	90/207 (43%)
		ABC_membrane	957..1190	CDD:294371	72/240 (30%)
		PBP2_NikA_DppA_OppA_like	<1201..>1274	CDD:294989	19/79 (24%)
		ABCC_MRP_domain2	1246..1465	CDD:213211	109/221 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345114
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.650