Protein Alignment Mrp5 and Abcc10

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_001101671.1
• Gene: Abcc10 / 316231
• RGDID: 1306696
• Length: 1494
• Species: Rattus norvegicus
• Alignment Length: 1366
• Identity: 435/1366 - (31%)
• Similarity: 689/1366 - (50%)
• Gaps: 174/1366 - (12%)

  Fly    21 SSLMFCFAMPTFFKG-RKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKKKKTPSLLKA 84
            |...:.:..|...:| |.:.....|..|..:.....:|.....|.|          |:...|.:|
  Rat   223 SRFSYAWLAPLLARGVRGELRQPQDTCRLPRRLHPAYLARAFQAHW----------KEGAQLWRA 277

  Fly    85 SMNVFGWRLAGLGLVLFI-LEIGFRVTQPLFLGGLVAYYADASNQEGDNQ-TKAYLYALGVILTS 147
            ....||.....|||:..: ..:||  :.||.|..||.:.     :||... :...||.||:...|
  Rat   278 LYGAFGCCYIALGLLKMVGTMLGF--SGPLLLSLLVGFL-----EEGQEPLSHGLLYVLGLASGS 335

  Fly   148 ACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVI 212
            ..:.:..:.|...:..:.::||:|:.|::|||.|:|..:.   ...|:|:||:..|..||
  Rat   336 VISAVLQNQYGYEVRKVTLQARVAVLSILYRKTLKLGPSR---PPTGEVLNLLGTDSERL----- 392

  Fly   213 HMNY------LWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRT 271
             :|:      .|..|:::.|..||:|.::|::...|:.:.||.:|:...:..:......:.....
  Rat   393 -LNFAGSFHEAWGLPLQLAITLYLLYEQVGVAFLAGLVLALLLVPVNKVIATRIMANNQEMLRHK 456

  Fly   272 DERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGT---LQSFIMFVTRIS 333
            |.||::|.|::|||:|:|.:.||......:...||:|:..:|.:.|:...   |.:.:..|..|.
  Rat   457 DARVKLMTELLSGIRVLKFFRWEQALGDRVKACRTQELGRLRVIKYLDAACVYLWAALPVVICIV 521

  Fly   334 VFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETK 398
            :|::   :||||..|||.|.|...|..::|...:. .||..|:...|..||:.|||.|:
  Rat   522 IFIT---YVLLGHQLTATKVFTALALVHMLILPLN-NFPWVINGLLESKVSLDRIQRFL------ 576

  Fly   399 VRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDN 463
                  ||.... .:|....:|          |:...|....|..:.|     ||...|......
  Rat   577 ------DLPSYS-PEAYYSPDP----------PTEPSTVLELHEALFS-----WDPTGTSQKTFI 619

  Fly   464 ISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGT---LSYASQEPWLFTGTVRQN 525
            ..|:.|...||.::|.||.|||||:.|:.|||:...|.|.|:..   ...|:||||:...|:|.|
  Rat   620 SHLQVKKGMLVGIVGKVGCGKSSLLAAITGELHRLCGWVAVSDLSKGFGLATQEPWIQCATIRDN 684

  Fly   526 ILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYL 590
            :|||...|...||.|::.|||..|..:||..|:|.|||:|.:|||||:|||:||||||::..:||
  Rat   685 VLFGKTFDAQLYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKTLYL 749

  Fly   591 LDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESM-- 653
            |||||:|||..|..||..:|:.|.|.....||.||:.::||:||::::|:.|::...|....:
  Rat   750 LDDPLAAVDADVANHLLHRCILGVLGHTTRLLCTHRTEYLERADLVLLMEAGRLVRAGPPSEILP 814

  Fly   654 ----AKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAAESL-AAESP- 712
                |.:.|...:.:||       :|.:|                 |:.::|...|.| .|::.
  Rat   815 LVQAAPTALADKEQVTD-------SGQSP-----------------SVHNLEKTTEELDVAQNTS 855

  Fly   713 --MQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVN-----KNG 770
              :..:|.:.||.:.:.:|:.|:.|.|.||........:..|...:|.|.:|::|::     :|.
  Rat   856 GRLVQEESKSEGAVALHVYRAYWRAMGSGLATAILISLLLMQATRNGADWWLAHWLSQLKAGRNS 920

  Fly   771 EAERDT---------FMARLRRAFP--------ETRINADTDPVDIY---YFT--GINVSVIIFS 813
            ..||..         |..||....|        :...|..:| |..|   |.|  |:|   .:.:
  Rat   921 SEERPASSSPRSMGFFSPRLLLFSPGNLYIPLHKATSNGSSD-VHFYLTVYATIAGVN---SLCT 981

  Fly   814 LVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVM 878
            |:|::||...|::::.:||:.:...:..|.:.|:::.||||:|||||.|:..||:.||.::..::
  Rat   982 LLRAVLFAAGALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNILL 1046

  Fly   879 QIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLN 943
            ...:.::|::.||.....|.:|....|..::|.::..|.::.|:::||.::|.||:||||:.:|.
  Rat  1047 ANSVGLLGLLAVLGSGLPWLLLLLPPLSFIYYGVQRRYRASFRELRRLGSLTLSPLYSHLADTLA 1111

  Fly   944 GLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLD-------CVCVVYIAVITLSF 1001
            ||..:||.||......|.....:::....:...||.:    |||       ...|..||.|.|..
  Rat  1112 GLPVLRAAGATYRFEEENQRLLELNQRCQFASYATMQ----WLDIRLQLMGAAVVSAIAGIALVQ 1172

  Fly  1002 FLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKP 1066
            ......|.|.|||.::.|:.:||::...:....:.|..|.:|||:.||     ..|...:|:.:|
  Rat  1173 HQQGLANPGLVGLVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEY-----SCDIPQEPHGQP 1232

  Fly  1067 PK------DWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINAL 1125
            |:      .|...|.:.|.|:.|.|.|  .....|..:...:|..||:|||||||:|||||...|
  Rat  1233 PQSPHQRVSWLTQGSVEFQDVVLVYRP--GLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVL 1295

  Fly  1126 FR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEE 1189
            || |..:.|.:|:|..||:.|.|.:|||::::|||||.|||||:|.||||...:.|..||::||:
  Rat  1296 FRLLEPSAGQVLLDGVDTSQLELAELRSQLAVIPQEPFLFSGTVRENLDPQGLHEDRALWQALEQ 1360

  Fly  1190 VKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQT 1254
            ..|.:|...: .||..::.|.|.:.|:|||||:|||||:|.:.:||.:|||||:||.:||.|:|.
  Rat  1361 CHLSEVAMAI-GGLDGELGERGRDLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQ 1424

  Fly  1255 TIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSP----------FELLTTSEKKVFHS 1309
            ||..:|.:.|||||||||:|:::||:|||:.||:.||..||          |..|..|.::..||
  Rat  1425 TICRRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSALRNQPHSLFRQLLQSSQQGAHS 1489

  Fly  1310 M 1310
            :
  Rat  1490 L 1490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	425/1307 (33%)
Abcc10	NP_001101671.1	MRP_assoc_pro	201..1471	CDD:188098	430/1345 (32%)