Protein Alignment Mrp5 and Abcc9

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_037172.2
• Gene: Abcc9 / 25560
• RGDID: 3787
• Length: 1545
• Species: Rattus norvegicus
• Alignment Length: 1362
• Identity: 414/1362 - (30%)
• Similarity: 689/1362 - (50%)
• Gaps: 200/1362 - (14%)

  Fly    67 KEVEKKRKKK------KTPSLLKASMNVFGWRLAGLGLVLFILE-IGFRVTQPLFLGGLVAYYAD 124
            ||..:::|||      :|||:..|....||..:.......::.: :||  ..||.:.|:|    .
  Rat   265 KEAYEEQKKKAADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGF--AGPLCISGIV----Q 323

  Fly   125 ASNQEGDNQT--------KAYL---YALGVILTSACNVLFMHPYMLGMFHI----GMKARIAMTS 174
            ..|:..:|.|        |.:|   :.|.|:|..|  ::....::...:::    |:..|.|:.:
  Rat   324 RVNEPKNNTTRFSETLSSKEFLENAHVLAVLLFLA--LILQRTFLQASYYVTIETGINLRGALLA 386

  Fly   175 MIYRKALRLSRT--ALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGI 237
            |||.|.||||.:  ::|:.|:||:.||::.:..:|...:.....||..||:|.:...|:|..:|.
  Rat   387 MIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGS 451

  Fly   238 SAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMIN 302
            ||..|.||::|..|:|.::..|.:..:..|...:.||::..|||:.||:::|:||||..|.|.:.
  Rat   452 SALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVE 516

  Fly   303 YVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVFVS--------LVGFV----LLGKLLTAEKAFV 355
            ..|.||::          :|::|.:: |.:|:|::        |..||    ..|..|...:||.
  Rat   517 ETRMKELS----------SLKTFALY-TSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFA 570

  Fly   356 ITAYYNILRNTMTVYFPMG-ISQFA-ELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIA 418
            ..:.::||   :|..|.:. :.:|| :.::|::::..|:|.:|.       ..|..:.|:..|..
  Rat   571 SLSLFHIL---VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEI-------GEDSWRTGEGTLPF 625

  Fly   419 EPTVAQTTGVLKPSSR-----------------RTSEAEH-SIVISKLKAKWDQKNTDNTLDNIS 465
            |.....|....||.:|                 |.:|.|. :|.::.....|.....  ||.||.
  Rat   626 ESCKKHTGVQSKPINRKQPGRYHLDNYEQARRLRPAETEDVAIKVTNGYFSWGSGLA--TLSNID 688

  Fly   466 LKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNG-----------------TLSYASQ 513
            ::....||..::|.||.|||||:.|:|||:....|.|..|.                 :::||:|
  Rat   689 IRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQ 753

  Fly   514 EPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISL 578
            :|||...||.:||.||...::.||:.|...|:|:.|.:|||:.|:|.:||||.:|||||:.||.:
  Rat   754 KPWLLNATVEENITFGSSFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICV 818

  Fly   579 ARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREE--IVLLVTHQLQFLEQADVIVIMDK 641
            |||:|:..:|..||||.||:|.|:..||..:.:..||:::  .|:||||:||:|..||.|:.|..
  Rat   819 ARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKD 883

  Fly   642 GKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKL-RDRHGSISSME---- 701
            |.:...||.:.:....::..:..               |..::||:.:| :|.....:::|
  Rat   884 GSVLREGTLKDIQTKDVELYEHW---------------KTLMNRQDQELEKDMEADQTTLERKTL 933

  Fly   702 -SAAESLAAESPMQTQEGRVEG------------RIGMKLYKK----YFGANGYGLFIVFAFFCI 749
             .|..|..|::.|:.::...|.            |:..|:..|    |..:.|:.|.    |..|
  Rat   934 RRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWWYLTSGGFFLL----FLMI 994

  Fly   750 GAQVLASGGDIFLSYW---------VNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGI 805
            .:::|.....:.:.||         :|..|:|::                        .:|..|.
  Rat   995 FSKLLKHSVIVAIDYWLATWTSEYSINDPGKADQ------------------------TFYVAGF 1035

  Fly   806 NV---SVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVD 867
            ::   :.|...||.|:...::.:.::..||:.:...:....:.||:|.|.|.||||||.|...:|
  Rat  1036 SILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIID 1100

  Fly   868 EILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRS 932
            :.:|..:..:.:..|..:..:.::......:::|...|.:.||.::.::...|:|::.|:..|:.
  Rat  1101 QHIPPTLESLTRSTLLCLSAIGMISYATPVFLIALAPLGVAFYFIQKYFRVASKDLQELDDSTQL 1165

  Fly   933 PIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDC------VCV 991
            |:..|.|.:..||.|||||..:...........|.::..|....|.:|    ||:.      .|:
  Rat  1166 PLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANR----WLEVRTDYLGACI 1226

  Fly   992 VYIAVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEG 1056
            |..|.|.   .:....|.|.|||.:..|:.:|..:.|.:|..|:||..|.||::|..:..:|.|.
  Rat  1227 VLTASIA---SISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESEN 1288

  Fly  1057 DFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSL 1121
            ...:....:.|:.||::|:|...||.::|  :.....||:.:...|:..:||||.||||:|||||
  Rat  1289 YEGTMDPSQVPEHWPQEGEIKIHDLCVRY--ENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSL 1351

  Fly  1122 INALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWE 1185
            ..|.||: ...:|.|:||..|.:.|.||.|||::|||.|:|:||||::|:||||..:.:|.:|||
  Rat  1352 SLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWE 1416

  Fly  1186 SLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDA 1250
            :||..:||.:|..||.||.:.::|||.|||||||||.|||||.:|::.||:||||||::|..|:.
  Rat  1417 ALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN 1481

  Fly  1251 LIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVK 1312
            ::|..:...|.|.||:|||||:||::.:|.|:||..|..:|:.:| |.|...|..||.|.|:
  Rat  1482 ILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTP-ESLLAQEDGVFASFVR 1542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	408/1344 (30%)
Abcc9	NP_037172.2	MRP_assoc_pro	222..1542	CDD:188098	413/1360 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	940..963		3/22 (14%)