DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4562 and Abcc8

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:NP_037171.2 Gene:Abcc8 / 25559 RGDID:3786 Length:1582 Species:Rattus norvegicus


Alignment Length:1427 Identity:435/1427 - (30%)
Similarity:697/1427 - (48%) Gaps:223/1427 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 MPTFFK-GRKKTLDENDL------YRALQEHRSDHLGSKLSAAWEKEVEKKRKKKK-TPSLLKAS 85
            |..|.| ..||.:|...:      .|||..::      :|..|::.:..|..:.:: ..::.:|.
  Rat   233 MNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQ------RLCLAFDAQARKDTQSQQGARAIWRAL 291

  Fly    86 MNVFGWRLAGLGLVLFILEIGFRV-------TQPLFLGGLV------------------AYYADA 125
            .:.||.||        :|...||:       ..||.:.|:|                  .|:..:
  Rat   292 CHAFGRRL--------VLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSS 348

  Fly   126 SNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHI----GMKARIAMTSMIYRKALRLSRT 186
            ....|:      .|.|.|:|..|  :|....::...:::    |:..|.|:.:.||.|.:.||.:
  Rat   349 QEFLGN------AYVLAVLLFLA--LLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTS 405

  Fly   187 --ALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLF 249
              ::|:.|.||:.||::.|..:|.........||..||:|.:...|:|..:|:||..|.||::|.
  Rat   406 NLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILL 470

  Fly   250 IPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRN 314
            .|:|.::..|.|..:..|...::||::..||::.||:::|:||||..|...:...|.|||.::| 
  Rat   471 APVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEKTRRKEMTSLR- 534

  Fly   315 VNYIRGTLQSFIMFVTRISVF-----------VSLVGFVLLGKL--LTAEKAFVITAYYNILRNT 366
                     :|.:: |.||:|           ::.||.|...|.  .:...||...:.::||   
  Rat   535 ---------AFAVY-TSISIFMNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHIL--- 586

  Fly   367 MTVYFPMG--ISQFAELLVSIRRIQTFMLHEETKVRDKS----EDLDEQKLGKAGLI-------A 418
            :|..|.:.  :....:.|||::::..|:  ...::|::.    |...:.:.||...:       .
  Rat   587 VTPLFLLSSVVRSTVKALVSVQKLSEFL--SSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRK 649

  Fly   419 EPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDN------------------TLDNIS 465
            .|...:...:|.|..|.|...:              .:.||                  ||.||:
  Rat   650 RPAREEVRDLLGPLQRLTPSTD--------------GDADNFCVQIIGGFFTWTPDGIPTLSNIT 700

  Fly   466 LKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSV---------------------------K 503
            ::....||..::|.||.|||||:.|.|||:...||:|                           :
  Rat   701 IRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSSLPDSEGEDPSNPERETAADSDAR 765

  Fly   504 VNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASL 568
            ..|.::||||:|||...||.:||.|..|.:|.||:.|::.|:|:.|.::||:.|:|.:||||.:|
  Rat   766 SRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINL 830

  Fly   569 SGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREE--IVLLVTHQLQFLE 631
            ||||:.|||:|||:|:..::..||||.||:|.|:..||....:...||::  .|:||||:||:|.
  Rat   831 SGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLP 895

  Fly   632 QADVIVIMDKGKISAMGTYESMAKSGLD-FAQMLTDPSKKDEG-------AGDAPD-----KKSL 683
            .||.|:.|..|.|...||.:...:|... |....|..:::|:.       ...||:     .:::
  Rat   896 HADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAM 960

  Fly   684 SRQNSKLRDRHGSISSMESAAESLAAESPMQTQEGRV---EGRIGMKLYKKYFGANGYGLFIVFA 745
            |.::..|.|        |...|..||||........|   ..:|..:...||..:.|..|..:..
  Rat   961 SSRDGLLLD--------EDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGILLLSLLV 1017

  Fly   746 FFCIGAQVLASGGDIFLSYWVNK-------NGEAERDTFMARLRRAFPETRINADTDPVDIYYFT 803
            |    :|:|.....:.:.||:.|       ...|.|:..:::      |..::   ..|....||
  Rat  1018 F----SQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQ------ECALD---QSVYAMVFT 1069

  Fly   804 GINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDE 868
            .:....|...||.|:...:..::.:..||.::...:..|.|.||.|.|.|.||||||.|...:|:
  Rat  1070 VLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQ 1134

  Fly   869 ILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSP 933
            .:||.:..:.:..|..|..:.|:..:...:::|.:.|.:|.|.::.::...|||:::|:..|:.|
  Rat  1135 HIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLP 1199

  Fly   934 IYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDC------VCVV 992
            :.||.:.::.||.|||||..:.....:...|.|.::.......|.:|    ||:.      .|||
  Rat  1200 LLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANR----WLEVRMEYIGACVV 1260

  Fly   993 YIAVIT-LSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEG 1056
            .||..| :|..|....:.|.|||.:|.|:.::..:.|.:|..|::|..:.||:|:......|.|.
  Rat  1261 LIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAES 1325

  Fly  1057 DFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSL 1121
            ..........||:||:.|||...:||::|  |.:...||:.:|..|...:|:||.||||:||||.
  Rat  1326 YEGLLAPSLIPKNWPDQGKIQIQNLSVRY--DSSLKPVLKHVNALISPGQKIGICGRTGSGKSSF 1388

  Fly  1122 INALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWE 1185
            ..|.||: ...||.|:||..|...|.||.|||::|||.|:|||||||:|:||||..:.||:.|||
  Rat  1389 SLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWE 1453

  Fly  1186 SLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDA 1250
            :||..:||.||..||.||.:.|:|||.|||.|||||.|||||.:|:..|.:||||||::|..|:.
  Rat  1454 ALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATEN 1518

  Fly  1251 LIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVK 1312
            ::|..:...|.|.||:|||||:||::.:|.|:|:..|..:||..|.:||:..: .||.|.|:
  Rat  1519 ILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKD-SVFASFVR 1579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 430/1413 (30%)
ABC_membrane 98..367 CDD:294371 80/312 (26%)
ABCC_MRP_domain1 443..643 CDD:213217 88/246 (36%)
ABC_membrane 799..1027 CDD:294371 67/234 (29%)
ABCC_MRP_domain2 1074..1295 CDD:213211 113/221 (51%)
Abcc8NP_037171.2 CFTR_protein 223..1582 CDD:273530 435/1427 (30%)
ABC_membrane <375..590 CDD:279056 66/228 (29%)
P-loop_NTPase 679..907 CDD:304359 86/227 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 741..768 0/26 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..962 2/22 (9%)
ABC_membrane 1017..1295 CDD:279056 77/294 (26%)
ABCC_SUR2 1343..1582 CDD:213255 120/240 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345062
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.650

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