DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abc4

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_594558.1	Gene:	abc4 / 2543059	PomBaseID:	SPAC30.04c	Length:	1469	Species:	Schizosaccharomyces pombe

Alignment Length:	1320	Identity:	394/1320 - (29%)
Similarity:	650/1320 - (49%)	Gaps:	135/1320 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PENPREKSNIFSSLMFCFAM------PTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKE 68
            ||:..:.|......||.||.      |.....:::.::.:|. ..:.::..       :.||...
pombe   219 PEDNYQPSAEQVCSMFNFACSYGYLNPLVLTAKRRVVEVDDT-PVIPDYDK-------NKAWTYR 275

  Fly    69 VEKKRKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQ 133
            .|    :.|||||......:|..::.|:|:..|::.: .:...|:.|..|:.:....|:...:..
pombe   276 FE----RMKTPSLFITIHKIFWRQILGMGVSSFMVSV-CQFLSPIALNRLLKHLESPSSSSVNPL 335

  Fly   134 TKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKAL--RLSRTALGDTTIGQV 196
            ....|...|..|||    ||...|:........::...:...||.|.:  |..:...||:.:|:.
pombe   336 VWIVLLLTGPFLTS----LFTQFYLFMSTRYLARSYTTLVQQIYNKVIRSRFVQNKSGDSKVGRS 396

  Fly   197 VNLISNDVGRLDVSVIH--MNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKK 259
            .||||.||.  |:..|.  ::.:...||||....||:.:.:|.||:.|:|:.:|...:...||..
pombe   397 NNLISTDVD--DIGEIREFIHIIVRAPVEIAGSIYLLQKLLGWSAYVGLALTVLTCSVPIVLGPL 459

  Fly   260 TSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQS 324
            .:.|.|:....||.|:.:|:|::..|::.|.:.||:|....:...|..|:|....:..:...:|.
pombe   460 VAKLTLRANRATDSRIELMSELLQSIRITKFFGWELPMLDRVKQRRQVELNRTWKLLLMEICIQV 524

  Fly   325 FIMFVTRISVFVSLVGF-VLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRI 388
            .:..:...|:|.:.|.| .::|:.:|...||...:.::.:| |...:....:.|..::.|||.|:
pombe   525 LVESLPVFSMFATFVVFTTIMGQTITPSIAFTSISLFSFIR-TQFSWIAYLMRQIVQIFVSIGRV 588

  Fly   389 QTFMLHEETKVRDKSEDLDE--QKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAK 451
            ..| |::..:| |....:::  |::|...       |..|.|..||.
pombe   589 SDF-LNDPDEV-DPVNTIEDTSQEIGFFN-------ASLTWVSNPSP------------------ 626

  Fly   452 WDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKV--NGTLSYASQE 514
                 .|..|.::::.|...:|..||||.||||||||.|:||||:.:.||..:  :..:||.||.
pombe   627 -----GDFCLRDLNIVFPRNKLSIVIGPTGSGKSSLISALLGELSLNKGSYNLPRSKGVSYVSQV 686

  Fly   515 PWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLA 579
            |||...|:|.||||..|..:.||:.|::.|.|..|.:....:|.|.:||:|.:||||||.||:||
pombe   687 PWLRNATIRDNILFDYPYIEERYKKVIQACGLLTDLQSFVASDLTEIGEKGVTLSGGQKQRIALA 751

  Fly   580 RAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLRE-EIVLLVTHQLQ-FLEQADVIVIMDKG 642
            ||||....|.|:||..||:|.|....::..|.:..|.| ..|:||||.:. |::.|..||.:..|
pombe   752 RAVYSPTSIVLMDDVFSALDIHTSNWIYKHCFQSSLMENRTVILVTHNVHLFMDSAAFIVTVKNG 816

  Fly   643 KISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAAESL 707
              ||....:.  .|.|.|  :....:...|.|  |||..::...|        .:...|:|.|.
pombe   817 --SAFPVTDK--SSPLLF--LAEQAASASEAA--APDLAAIPIPN--------EVDDAEAADEK- 864

  Fly   708 AAESPMQTQEGRVEGRIGMK---LYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKN 769
              :..:..:|.||.|.:...   .|.|:|| :|:.:..|..|| :..|..:...|:::::|.|.:
pombe   865 --DGKLVEEEQRVTGDVVFSEIFSYMKHFG-SGFYVAAVLLFF-VTTQATSILIDLWVAFWTNSS 925

  Fly   770 GEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNT 834
            ..:             |:...|.     .::.:..:.::..:...:|::.:...|..:|..||::
pombe   926 VNS-------------PDVNNNK-----FLFVYGTMLLAYSLLDFLRTVSYDRGAWWASRKLHDS 972

  Fly   835 MFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYI 899
            |.:.|......:|:..|:|||:|||:||:..:|..|...:...:..||::.|.::.:......::
pombe   973 MLESVFGTFASWFDKTPTGRIVNRFAKDIRSIDMNLSGWLFFSINCFLSVAGGILSVSSAMPIFM 1037

  Fly   900 LATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQ---KELIAE- 960
            :..|.:.:..|...:.|......||||.::..|||:|.|..|:.|::.||||..|   |::.:|
pombe  1038 IPAVIVCLAGYYFGLLYTRAQVGVKRLISIYTSPIFSLLGESIVGVSVIRAFNRQTIFKQMFSER 1102

  Fly   961 FDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSFFLFSPENGGDVGLAITQAMGMTGM 1025
            .||...:.|:.|.:    :|......|.:..:..|:..|...|....:.|.||.::.||:..:..
pombe  1103 LDNLVRLQSTSYNL----NRWVAVRTDGISGLVGAIAGLIALLQKDLSPGVVGFSLNQAVIFSSS 1163

  Fly  1026 VQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPN--KKPPKDWPEDGKIVFDDLSLKYFPD 1088
            |...:|....|:..|.:.|||:||..| |:   |..|.  .:.|..||::|.|||:.:|:.|  .
pombe  1164 VLLFVRSCNSLQAEMNSYERVLEYSKL-PQ---EPAPTIAGQVPATWPKEGDIVFNHVSVSY--S 1222

  Fly  1089 KAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYN-EGAILIDRRDTNDLGLHDLRS 1152
            .|...:|:.:|:.|...|||.:|||||:|||:|...|.|.::. .|.|.|:.|:|..:.|:.||.
pombe  1223 AAGPTILKDVNLHINPSEKVAVVGRTGSGKSTLGLTLLRFTHRISGEIYINGRETQSVNLNALRQ 1287

  Fly  1153 KISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVV-------ADLPSGLQSKISEG 1210
            :||.|||:|:|||||:|.|||||||..|..|.|:|:......::       ..:...|.:.::..
pombe  1288 RISFIPQDPILFSGTVRSNLDPFDELEDNFLNEALKTSGASSMIMAHTDDQKPIHITLDTHVASE 1352

  Fly  1211 GTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTV 1275
            |:|||.||:|::.|||||:|.::|:::||.||:||...|..||.|:|..|.|.|:|.|||||.|:
pombe  1353 GSNFSQGQKQVLALARAIVRRSKIIILDECTASVDDAMDQKIQKTLREAFGDATMLCIAHRLKTI 1417

  Fly  1276 MDSDKVLVMDAGKAVEFGSP 1295
            :|.|||:|:|.|..||:|.|
pombe  1418 VDYDKVMVLDKGVLVEYGPP 1437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	392/1318 (30%)
		ABC_membrane	98..367	CDD:294371	67/273 (25%)
		ABCC_MRP_domain1	443..643	CDD:213217	82/203 (40%)
		ABC_membrane	799..1027	CDD:294371	57/231 (25%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	101/228 (44%)
abc4	NP_594558.1	CFTR_protein	240..1449	CDD:273530	387/1299 (30%)
		ABC_membrane	300..568	CDD:294371	69/275 (25%)
		ABCC_MRP_domain1	611..817	CDD:213217	89/237 (38%)
		ABC_membrane	901..1164	CDD:294371	65/285 (23%)
		ABCC_MRP_domain2	1210..1437	CDD:213211	101/228 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.900