DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abc3

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_595055.1	Gene:	abc3 / 2540937	PomBaseID:	SPBC359.05	Length:	1465	Species:	Schizosaccharomyces pombe

Alignment Length:	1362	Identity:	465/1362 - (34%)
Similarity:	733/1362 - (53%)	Gaps:	138/1362 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SNIFSSLMFCFAMPTFFK-GRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKKKKTPS 80
            :||||.|.|.: :.:|.| |....|.|:|::....:.||.:|.......|....:.||:     |
pombe   177 ANIFSKLSFSW-ISSFIKFGYTNYLKESDVWLLPPDERSGNLIIGFEDWWIYHSKNKRR-----S 235

  Fly    81 LLKASMNVFG-WRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVI 144
            |....:..|. |:|..|..:..:::......||..:...:.:.:..::...::.::.::.|:.|:
pombe   236 LFLWKLLFFNHWKLVALITITKLIQDVLAFVQPTLIQKTILFISSYTSPNPESPSRGFIIAILVL 300

  Fly   145 LTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDV 209
            :.:....|.:..|...:..:||:.:..:.:.||||:|.||.:|..:.:||.::|.::.|..::..
pombe   301 VANFLQTLLLQQYNQLIMLLGMRWKTELLASIYRKSLLLSSSARQNRSIGDIINYMAVDTQKISD 365

  Fly   210 SVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIP---LQAYLGKKTSVLRLKTALRT 271
            ..|::..:..||.:|.:....:|..:|.|||.|||..::..|   :.|.:.||...:.:|   ..
pombe   366 LPIYLFIIVSGPFQIALALSNLYHLMGYSAFTGVAASVILFPCNIIVANVYKKFQSILMK---NK 427

  Fly   272 DERVRMMNEIISGIQVIKMYAWEIPFSKMINYVR-TKEMNAIRNVNYIRGTLQSFIMFVTRISVF 335
            |.|.::|.|||:.|:.||:||||.||.:.:.::| |||::.::.:.:|........:|.|.|...
pombe   428 DSRSKLMTEIINNIRSIKLYAWETPFLQKLLHIRNTKELSMLKKIGFITAIGDFAWIFTTIIVTT 492

  Fly   336 VSLVGFVLL-GK--LLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEET 397
            |:...|::. ||  .|||:..|...:.:|:|:..:.: .|..||...|..||:.||..|::
pombe   493 VAFGAFIIFHGKTQALTADIVFPAVSLFNLLQFPLAM-LPTVISSLLEASVSVSRIYEFLI---- 552

  Fly   398 KVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKA---KWDQKNTDN 459
                      .|:|...|:...|               .:|..|.|.: ::|:   .|.:|....
pombe   553 ----------AQELDYNGVQRFP---------------ATEIPHEICL-EIKSGTFSWSKKTLKQ 591

  Fly   460 ----TLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTG 520
                ||..|:...|..:|..:.|.||:|||||::|.:|.:..:||||...|:|:||:|:||:|..
pombe   592 QVTPTLRQINFVAKNGELTCIFGKVGAGKSSLLEACMGNMYKNSGSVFQCGSLAYAAQQPWIFDA 656

  Fly   521 TVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRK 585
            |:|:|||||...|...|...:..|.|:||||:....|:|.||::|||||||||:|||||||:|.:
pombe   657 TIRENILFGSEFDPELYEKTIHACCLKRDFEIFTEGDQTEVGQKGASLSGGQKSRISLARAIYSQ 721

  Fly   586 ADIYLLDDPLSAVDTHVGRHLFDQCM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMG 648
            ||||||||.||:||.||.|.|.....  .||||...|:|.|:.|..|::||.|.|:..|||...|
pombe   722 ADIYLLDDVLSSVDQHVSRDLIKNLFGPEGFLRTHCVVLTTNSLNVLKEADSIYILSNGKIVEKG 786

  Fly   649 TYESM-AKSGLDFAQMLTD-------------------------PSKKDEG-----AGDAPD--K 680
            .||.: ..:..:..|.|::                         ||...||     :.:..|  .
pombe   787 NYEHLFVSTNSELKQQLSEFNDEKDTQPLPEHTTSYPSTQISLAPSIHVEGLETYSSSERKDSSN 851

  Fly   681 KSLSRQNSKLRDRHGSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFA 745
            |..||:.:.:|         :...|....:...||.|....|::...:|..||.:...||.:::.
pombe   852 KYKSRKRNPIR---------QKVTEDDKGKCVAQTDELVQRGKVKWHVYWMYFKSCSIGLILLYF 907

  Fly   746 FFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDP-----VDIYYFTGI 805
            ||.|...::....:::|.:|..:||::                  :::.:|     :.||.|.|.
pombe   908 FFIISGIMMNVATNVWLKHWSEENGKS------------------SSELNPSPYFYLGIYLFFGF 954

  Fly   806 NVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEIL 870
            .....|.|...:|... ..:||...||::|.:.:.||.|.||.|..|||||||||.|:.:|||::
pombe   955 LSCAFISSSSLTMTVL-CGIRSGRYLHDSMLKTILRAPMGFFETTSSGRILNRFSNDVYKVDEVV 1018

  Fly   871 PSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIY 935
            ....|...:..:.::.|:.|:|......:|..|.|..::...|.:|:.|||::|||:.|||||:|
pombe  1019 SLTFMFFFRNSIQVLFILGVICYSAPLSLLLIVPLFFLYLYNRAYYVRTSRELKRLDNVTRSPLY 1083

  Fly   936 SHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCV------CVVYI 994
            :|:..||:||:||||:|.|:..:.|.|...|.:...::||.::||.....::|:      |..:.
pombe  1084 AHVQESLSGLSTIRAYGMQETFVEENDLRIDTNHRVWFMFFSSSRWQAIRVECIGDLIIFCTAFY 1148

  Fly   995 AVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFE 1059
            .:  ||....|| |.|.||.:::.|:.:|..:.:.::||.:.||...:|||::||.:::.|.. |
pombe  1149 GI--LSAIKGSP-NPGLVGFSLSYAIQITQGLSFIVQQSVDAENNTVSVERILEYINVKSEAP-E 1209

  Fly  1060 SKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINA 1124
            ..|..:||.:||.||.:.|:..|.||..|  ..:.|.::||.|...||:|||||||||||:|..|
pombe  1210 IIPENRPPCEWPTDGAVSFNHYSAKYRED--LSFALNNINIEISPREKIGIVGRTGAGKSTLAMA 1272

  Fly  1125 LFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLE 1188
            ||| :...||.|.||..|....||:||||::||||||..:|.|.:|.||||....:|.|:||.||
pombe  1273 LFRIIEPTEGKIEIDNEDITKFGLYDLRSRLSIIPQESQIFEGNIRENLDPNHRLTDKKIWEVLE 1337

  Fly  1189 EVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQ 1253
            ...||..::.|..||.|:::|||.|||.|||||:||||.:|...|||::|||||:|..:|||::|
pombe  1338 IASLKNCISQLEDGLYSRVAEGGANFSSGQRQLICLARVLLTSTRILLLDEATASVHAETDAIVQ 1402

  Fly  1254 TTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            .|||.:|||.|:||:|||::||||||::||:|.||.|||.:..:||...: .:|:|:.|::|
pombe  1403 QTIRKRFKDRTILTVAHRINTVMDSDRILVLDHGKVVEFDATKKLLENKD-SMFYSLAKESG 1463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	460/1345 (34%)
		ABC_membrane	98..367	CDD:294371	70/275 (25%)
		ABCC_MRP_domain1	443..643	CDD:213217	96/208 (46%)
		ABC_membrane	799..1027	CDD:294371	82/233 (35%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	120/221 (54%)
abc3	NP_595055.1	MRP_assoc_pro	101..1464	CDD:188098	465/1362 (34%)
		ABC_membrane	254..527	CDD:294371	70/275 (25%)
		ABCC_MRP_domain1	575..781	CDD:213217	95/206 (46%)
		ABC_membrane	907..1177	CDD:279056	90/291 (31%)
		ABCC_MRP_domain2	1224..1443	CDD:213211	120/220 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	170	1.000	Domainoid score	I894
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720