DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and Abcc2

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_036965.1	Gene:	Abcc2 / 25303	RGDID:	2366	Length:	1541	Species:	Rattus norvegicus

Alignment Length:	1414	Identity:	489/1414 - (34%)
Similarity:	764/1414 - (54%)	Gaps:	181/1414 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEK---- 71
            :.|...::..||:.|.:...|..||.|..|...|::...:..::..:.||..||..|:::|
  Rat   191 QTPSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKDLQKARQA 255

  Fly    72 -----------------------------------KRKKKKTPS------LLKASMNVFGWRLAG 95
                                               |:|.:||..      |:|:....|...:
  Rat   256 FQRRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSWLIKSLFKTFHVVI-- 318

  Fly    96 LGLVLFILEIGFRV---TQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPY 157
              |..|||::...:   ..|..|..|:.:...:::........|.|.....::.|.|    :..|
  Rat   319 --LKSFILKLIHDLLVFLNPQLLKLLIGFVKSSNSYVWFGYICAILMFAVTLIQSFC----LQSY 377

  Fly   158 MLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPV 222
            ....|.:||..|..:.|.||:|||.||..|....|||:.|||:|.|..:|..:..:|..:|...:
  Rat   378 FQHCFVLGMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLMDATNYMQLVWSSVI 442

  Fly   223 EIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQV 287
            :|.:..:.::||:|.|...||.||:|.||:...|..|...::::.....|:|:::||||:|||::
  Rat   443 QITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEILSGIKI 507

  Fly   288 IKMYAWEIPFSKMINYVRTKEMNAIRNVNYIR-GTLQSFIMFVTRIS-VFVSLVGF---VLL--G 345
            :|.:|||..|.:.:..:|.||:.     |.:| |.|||.::|:.:|: :.||:|.|   ||:  .
  Rat   508 LKYFAWEPSFQEQVQGIRKKELK-----NLLRFGQLQSLLIFILQITPILVSVVTFSVYVLVDSA 567

  Fly   346 KLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQK 410
            .:|.|||||.....:||||..::: .||..|...:..||:.|::.::         ..:|||...
  Rat   568 NVLNAEKAFTSITLFNILRFPLSM-LPMVTSSILQASVSVDRLERYL---------GGDDLDTSA 622

  Fly   411 LGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVA 475
            :                      ||.|..:.::..|:....|| .:.:.|:.:::|..||.||||
  Rat   623 I----------------------RRVSNFDKAVKFSEASFTWD-PDLEATIQDVNLDIKPGQLVA 664

  Fly   476 VIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTV 540
            |:|.||||||||:.|:|||:....|.:.:.|:.:|..|:.|:..||::.|||||...::.:|:.|
  Rat   665 VVGTVGSGKSSLVSAMLGEMENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSEYNEKKYQQV 729

  Fly   541 VKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRH 605
            :|.|||..|.|:||..|...:||:|.:||||||.|:|||||.|:.||||:|||||||||.|||:|
  Rat   730 LKACALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKH 794

  Fly   606 LFDQCM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMA-KSGLDFAQ----- 662
            :|::.:  .|.|..:..:.|||.:.||.|.|.||::.||.|...|:|..:. |.|: ||:
  Rat   795 IFNKVVGPNGLLAGKTRIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGV-FARNWKTF 858

  Fly   663 -----------MLTDPSKKDEGAGDAP-------DKKSLS--RQNSKLRDRHGSISSMESAAESL 707
                       :..|...:|:..|..|       |..||:  |:||..|....|..|.....:||
  Rat   859 MKHSGPEGEATVNNDSEAEDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLSRSSRSSSRRGKSL 923

  Fly   708 AAE------SPMQTQEGRVE------------GRIGMKLYKKYFGANGYG--LFIVFAFFCIGAQ 752
            ...      :.::.:|..||            |::...:|.||..|.|:.  |||:. |:.:. .
  Rat   924 KNSLKIKNVNVLKEKEKEVEGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSILFIIL-FYGLN-N 986

  Fly   753 VLASGGDIFLSYWV----NKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFS 813
            |...|.:::||.|.    |.||                 |..::....:.|..|..:.::..|..
  Rat   987 VAFIGSNLWLSAWTSDSDNLNG-----------------TNNSSSHRDMRIGVFGALGLAQGICL 1034

  Fly   814 LVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVM 878
            |:.::...|....:|..||..:...:.||.|.||:|.|:|||:||||.|:..||::||..:...|
  Rat  1035 LISTLWSIYACRNASKALHGQLLTNILRAPMRFFDTTPTGRIVNRFSGDISTVDDLLPQTLRSWM 1099

  Fly   879 QIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLN 943
            ..|..|.|.:|::|:....:.:..:.|.|::..::|||::|||.::||::||:||||||.|.::.
  Rat  1100 MCFFGIAGTLVMICMATPVFAIIIIPLSILYISVQVFYVATSRQLRRLDSVTKSPIYSHFSETVT 1164

  Fly   944 GLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSFFLFSPEN 1008
            ||..||||..|:..:|..:...|::....:.::.::|.....|:.|..:.:....|...::....
  Rat  1165 GLPIIRAFEHQQRFLAWNEKQIDINQKCVFSWITSNRWLAIRLELVGNLVVFCSALLLVIYRKTL 1229

  Fly  1009 GGD-VGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPE 1072
            .|| ||..::.|:.:|..:.|.:|.::|.|..:.||||:.||.::|.|..:.:  :|:||.|||.
  Rat  1230 TGDVVGFVLSNALNITQTLNWLVRMTSEAETNIVAVERISEYINVENEAPWVT--DKRPPADWPR 1292

  Fly  1073 DGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNEGA-IL 1136
            .|:|.|::..::|.|:  .|.||:.:...|:..||||:|||||||||||.|.|||:..:.|. |:
  Rat  1293 HGEIQFNNYQVRYRPE--LDLVLKGITCNIKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQII 1355

  Fly  1137 IDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPS 1201
            ||..|...:||||||.:::||||:|:||||::|.|||||::|||.::|.:||...|:..|:.|..
  Rat  1356 IDGIDVASIGLHDLRERLTIIPQDPILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSFVSGLQL 1420

  Fly  1202 GLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVL 1266
            ||.|:::|||.|.|:|||||:||.||:||:::|||:|||||.||.:||:|||||||.:|..|||:
  Rat  1421 GLLSEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVI 1485

  Fly  1267 TIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            ||||||||:|||||::|:|.||.||:|||.|||  |.:..|:.|.|:.|
  Rat  1486 TIAHRLHTIMDSDKIMVLDNGKIVEYGSPEELL--SNRGSFYLMAKEAG 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	483/1396 (35%)
		ABC_membrane	98..367	CDD:294371	91/278 (33%)
		ABCC_MRP_domain1	443..643	CDD:213217	94/201 (47%)
		ABC_membrane	799..1027	CDD:294371	71/228 (31%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	125/221 (57%)
Abcc2	NP_036965.1	MRP_assoc_pro	7..1533	CDD:188098	489/1414 (35%)
		ABC_membrane	322..589	CDD:279056	90/275 (33%)
		ABCC_MRP_domain1	633..834	CDD:213217	94/201 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..881		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	901..923		6/21 (29%)
		ABC_membrane	979..1245	CDD:279056	80/284 (28%)
		ABCC_MRP_domain2	1294..1514	CDD:213211	125/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345104
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660