DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and Abcb4

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_036822.1	Gene:	Abcb4 / 24891	RGDID:	620248	Length:	1278	Species:	Rattus norvegicus

Alignment Length:	1183	Identity:	265/1183 - (22%)
Similarity:	503/1183 - (42%)	Gaps:	208/1183 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 ISAFF---------GVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERV-------RMMNEIISGI 285
            |:.||         |..:.|:.:.:.|.||..|:|.....:..:|:.:       .:..|.:..|
  Rat   196 IATFFAGFIVGFIRGWKLTLVIMAITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAI 260

  Fly   286 QVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVFVSLVGFVLLGKLLTA 350
            :.:..:..:   :|.:...: |.:...:.:...:....:..|.:..:.::.|.......|..|..
  Rat   261 RTVIAFGGQ---NKELERYQ-KHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI 321

  Fly   351 EKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAG 415
            .|.:.|       .|.|||:|.:.|..|:                               :|:|.
  Rat   322 SKEYTI-------GNAMTVFFSILIGAFS-------------------------------VGQAA 348

  Fly   416 --LIAEPTVAQTTGVL------KPSSRRTSEAEH-------SIVISKLKAKWDQKNTDNTLDNIS 465
              :.|.|.......|:      .|.....||..|       ::..|.:...:..:.....|..::
  Rat   349 PCIDAFPNARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFSDVHFSYPSRANIKILKGLN 413

  Fly   466 LKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGT-------------LSYASQEPWL 517
            ||.|..|.||::|..|.|||:.:|.:....:|..|::.::|.             :...||||.|
  Rat   414 LKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVL 478

  Fly   518 FTGTVRQNILFG---LPMDKHRYRTVVKRCALER---DFEL-LPYADKTIVGERGASLSGGQKAR 575
            |:.|:.:||.:|   :.||:      :|:...|.   ||.: ||....|:||:|||.||||||.|
  Rat   479 FSTTIAENIRYGRGNVTMDE------IKKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQR 537

  Fly   576 ISLARAVYRKADIYLLDDPLSAVDTHVGRHL---FDQCMRGFLREEIVLLVTHQLQFLEQADVIV 637
            |::|||:.|...|.|||:..||:||.....:   .|:...|    ...:::.|:|..:..||||.
  Rat   538 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREG----RTTIVIAHRLSTVRNADVIA 598

  Fly   638 IMDKGKISAMGTY-ESMAKSGLDF---------AQMLTDPSK---KDEGA--GDAPD--KKSLSR 685
            ..:.|.|...|:: |.:.|.|:.|         :|:|::..:   .||.|  |.||:  |..:.|
  Rat   599 GFEDGVIVEQGSHSELIKKEGIYFRLVNMQTSGSQILSEEFEVELSDEKAAGGVAPNGWKARIFR 663

  Fly   686 QNSKLRDRHGSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYFGAN--GYGLFIVFAFFC 748
            .::|           :|...|.|.::.:..:...::..:....:.|....|  .:..|:|.....
  Rat   664 NSTK-----------KSLKSSRAHQNRLDVETNELDANVPPVSFLKVLRLNKTEWPYFVVGTLCA 717

  Fly   749 IGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFS 813
            |....|.....|.||..:...|..: ||...:....|.             ..|.|:.|......
  Rat   718 IANGALQPAFSIILSEMIAIFGPGD-DTVKQQKCNMFS-------------LVFLGLGVHSFFTF 768

  Fly   814 LVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFF--NTNPSGRILNRFSKDLGQVDEILPSVMMD 876
            .::...|.......:|.|.:..|:.:.|..|.:|  :.|.:|.:..|.:.|..||.....:.:..
  Rat   769 FLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLAL 833

  Fly   877 VMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYL------LRVFYLSTSRDVKRLEAVTRSPIY 935
            :.| ..|.:|..:::..|..|.:...:..|:.|..      :::...:..||.|.:||..:.
  Rat   834 IAQ-NTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKI--- 894

  Fly   936 SHLSASLNGLATIRAFGAQKELIAEFDNYQDMH---------SSGYYMFLATSRAFGYWLDCVCV 991
              .:.::..:.|:.:...:::..:.:  .:.:|         :..|.:..:.|:||.|:....|.
  Rat   895 --ATEAIENIRTVVSLTQERKFESMY--VEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCF 955

  Fly   992 VYIAVITLSFFLFSPENG----GDVGLAITQAMGMTGMVQWGMRQS--AELENTMTAVERVVEYE 1050
            .:.:.:.:        ||    .||.|..:..  :.|.|..|...|  .:......:...:....
  Rat   956 RFGSYLIV--------NGHMRFKDVILVFSAI--VLGAVALGHASSFAPDYAKAKLSAAYLFSLF 1010

  Fly  1051 DLEPEGDFESKPNKKPPKDWPE--DGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGR 1113
            :.:|..|..|:...     ||:  :|.:.|:::...| |.:|...||:.|::.::..:.:.:||.
  Rat  1011 ERQPLIDSYSREGM-----WPDKFEGSVTFNEVVFNY-PTRANVPVLQGLSLEVKKGQTLALVGS 1069

  Fly  1114 TGAGKSSLINALFRLSYN--EGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNL---D 1173
            :|.|||:::..|.|. |:  .|.:|:|.::...|.:..||:::.|:.|||:||..::..|:   |
  Rat  1070 SGCGKSTVVQLLERF-YDPMAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGD 1133

  Fly  1174 PFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMD 1238
            .....|..::..:.:|..:...:..||...::::.:.||..|.||:|.:.:|||::|:.|:|::|
  Rat  1134 NSRVVSQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLD 1198

  Fly  1239 EATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSE 1303
            |||:.:|.:::.::|..:....:..|.:.|||||.|:.::|.::|:|.||..|.|:..:||  ::
  Rat  1199 EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLL--AQ 1261

  Fly  1304 KKVFHSMVK-QTG 1315
            |.::.|||. |.|
  Rat  1262 KGIYFSMVNIQAG 1274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	258/1165 (22%)
		ABC_membrane	98..367	CDD:294371	22/145 (15%)
		ABCC_MRP_domain1	443..643	CDD:213217	69/222 (31%)
		ABC_membrane	799..1027	CDD:294371	42/248 (17%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	67/225 (30%)
Abcb4	NP_036822.1	PTZ00265	29..1271	CDD:240339	263/1178 (22%)
		ABC_membrane	58..342	CDD:279056	27/156 (17%)
		ABC_MTABC3_MDL1_MDL2	392..628	CDD:213216	76/245 (31%)
		Interaction with HAX1. /evidence=ECO:0000269\|PubMed:15159385	622..646		3/23 (13%)
		ABC_membrane	714..984	CDD:279056	51/301 (17%)
		ABC_MTABC3_MDL1_MDL2	1033..1272	CDD:213216	72/242 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000