Protein Alignment CG4562 and Tap1

DIOPT Version :9

• Sequence 1: NP_001262747.1
• Gene: CG4562 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_114444.2
• Gene: Tap1 / 24811
• RGDID: 3817
• Length: 725
• Species: Rattus norvegicus
• Alignment Length: 576
• Identity: 147/576 - (25%)
• Similarity: 249/576 - (43%)
• Gaps: 100/576 - (17%)

  Fly   799 IYYFTGINVSVIIF-----SLVRSMLFFYLAMRSSTTL---------------HNTMFQGVTRAA 843
            |.:|||.....|:.     |..|:|....:...:||.|               |:.:...|.||.
  Rat   181 IPFFTGRITDWILQDKTAPSFARNMWLMCILTVASTALEFAGDGIYNITMGHMHSRVHGEVFRAV 245

  Fly   844 MH----FFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVW---YI-L 900
            :|    ||..||:|.|.:|.::|...|.|.:    .|.:.:||..:|..:.|....:|   |: :
  Rat   246 LHQETGFFLKNPTGSITSRVTEDTSNVCESI----SDKLNLFLWYLGRGLCLLAFMIWGSFYLTV 306

  Fly   901 ATVFLVIVFYLL--RVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFG-----AQK--E 956
            .|:..:.:.:||  |:..:..|..||..|::.:|...: |.| |:.:.|:|:|.     |||  :
  Rat   307 VTLLSLPLLFLLPRRLGKVYQSLAVKVQESLAKSTQVA-LEA-LSAMPTVRSFANEEGEAQKFRQ 369

  Fly   957 LIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYI--------AVIT---LSFFLFSPENGG 1010
            .:.|........:..|...:.|....|..|. |.::|:        ||.:   :||.|:.
  Rat   370 KLEEMKPLNKKEALAYVTEVWTMSVSGMLLK-VGILYLGGQLVVRGAVSSGNLVSFVLYQ----- 428

  Fly  1011 DVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEP----EGDFESKPNKKPPKDWP 1071
               |..|:|:.:...:...|::|      :.|.|::.||.|..|    .|.. :..|.|
  Rat   429 ---LQFTRAVEVLLSIYPSMQKS------VGASEKIFEYLDRTPCSPLSGSL-APLNMK------ 477

  Fly  1072 EDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNE--GA 1134
              |.:.|.|:|..| |:.....||:.|...:...:...:||..|:|||: :.||.:..|..  |.
  Rat   478 --GLVKFQDVSFAY-PNHPNVQVLQGLTFTLYPGKVTALVGPNGSGKST-VAALLQNLYQPTGGK 538

  Fly  1135 ILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNL------DPFDEYSDAKLWESLEEVKLK 1193
            :|:|.........|.|.::::.:.|||:||..:.|.|:      .|..|...|...||    ...
  Rat   539 VLLDGELLVQYDHHYLHTQVAAVGQEPLLFGRSFRENIAYGLTRTPTMEEITAVAMES----GAH 599

  Fly  1194 QVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRN 1258
            ..::..|.|..:::.|.|...|.||||.|.||||::|:.|:|::|:||:.:|......:|..:..
  Rat   600 DFISGFPQGYDTEVGETGNQLSGGQRQAVALARALIRKPRLLILDDATSALDAGNQLRVQRLLYE 664

  Fly  1259 --KFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVK 1312
              ::...|||.|..:|.....:..:|.:..|...|.|:..:|:  .....:.|||:
  Rat   665 SPEWASRTVLLITQQLSLAERAHHILFLKEGSVCEQGTHLQLM--ERGGCYRSMVE 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	144/562 (26%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217
		ABC_membrane	799..1027	CDD:294371	66/275 (24%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	66/230 (29%)
Tap1	NP_114444.2	3a01208	2..717	CDD:273363	145/573 (25%)
		ABC_membrane	177..435	CDD:279056	65/268 (24%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518	352..397		9/44 (20%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518	430..464		9/39 (23%)
		P-loop_NTPase	469..697	CDD:304359	67/242 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000