DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and Abcc1

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_071617.2	Gene:	Abcc1 / 24565	RGDID:	3112	Length:	1532	Species:	Rattus norvegicus

Alignment Length:	1405	Identity:	490/1405 - (34%)
Similarity:	751/1405 - (53%)	Gaps:	185/1405 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRK--- 74
            |...::..|.:.|.:......:|.::.|..:||:...:|..|:.:...|...|:||..|.||
  Rat   209 PESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKKECVKSRKQPV 273

  Fly    75 ----------------------------------KKKTPSLLKASMNVFGWRLAGLGLVLFILEI 105
                                              |.:.|||.|.....||        ..|::..
  Rat   274 RIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKTFG--------PYFLMSF 330

  Fly   106 GFRVTQPL--FLG-GLVAYYADASNQEGDNQTKAYLYALGVILTSAC-NVLFMHPYMLGMFHI-- 164
            .::....|  |.| .::....:..|.......:.|||. .::..||| ..|.:|.|    |||
  Rat   331 LYKALHDLMMFAGPEILELIINFVNDREAPDWQGYLYT-ALLFVSACLQTLALHQY----FHICF 390

  Fly   165 --GMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGII 227
              ||:.:.|:...:|||||.::.:|...:|:|::|||:|.|..|......::|.:|..|:::.:.
  Rat   391 VTGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLA 455

  Fly   228 TYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYA 292
            .|.::..:|.|...|||||:|.:|..|.:..||...::......|.|:::||||::||:|:|:||
  Rat   456 LYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYA 520

  Fly   293 WEIPFSKMINYVRTKEMNAIRNVNYIR--GTL----QSFIMFVTRISVFVSLVGFVLLGKLLTAE 351
            ||:.|...:..:|.:|:..::...|:.  ||.    ..|::.::..:|||:    |....:|.|:
  Rat   521 WELAFQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVT----VDEKNILDAK 581

  Fly   352 KAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGL 416
            ||||..|.:||||..:.: .||.||...:..||::|::.|:.|||
  Rat   582 KAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEE-------------------- 625

  Fly   417 IAEPTVAQTTGVLKPSS-RRTSEAE----HSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAV 476
                        |:|.| .|.|..:    :||.:......| .::...||:.|:.......||||
  Rat   626 ------------LEPDSIERWSIKDGGGMNSITVKNATFTW-ARDEPPTLNGITFAIPDGALVAV 677

  Fly   477 IGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVV 541
            :|.||.|||||:.|:|.|::...|.|.:.|:::|..|:.|:...::|:|||||.|:.:|.|:.|:
  Rat   678 VGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVM 742

  Fly   542 KRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHL 606
            :.|||..|.|:||..|.|.:||:|.:||||||.|:|||||||..:|||||||||||||.|||:|:
  Rat   743 EACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHI 807

  Fly   607 FDQCM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSK 669
            |::.:  .|.|:.:..:||||.:.:|.|.|||::|..||||.||:|:.:......||:.:...:.
  Rat   808 FEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFVRTYAN 872

  Fly   670 KDEGAGDAPDKKS----LSRQNSKLRD-------------RHGSISSMESAAESLAAESPMQTQE 717
            .::......|.|:    |.:::..:.:             ||.|.||..|...:....|..:.|:
  Rat   873 TEQDLASEDDSKNGVSGLGKESKPVENGILVTDAVGKPLQRHLSNSSSHSVVTNQQHSSTAELQK 937

  Fly   718 GRVE--------------GRIGMKLYKKYFGANG--YGLFIVFAFFCIGAQVLASGGDIFLSYWV 766
            ..|:              |::.:.:|..|..|.|  .....:|.|.|.....|||  :.:||.|.
  Rat   938 SGVKEETWKLMEADKAQTGQVKLSVYWNYMKAIGLCISFLSIFLFLCNHVSALAS--NYWLSLWT 1000

  Fly   767 NK----NGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRS 827
            :.    ||..|...|.                  :.:|...||...|.:|..  ||......:.:
  Rat  1001 DDRPAVNGTQENRNFR------------------LSVYGALGILQGVAVFGY--SMAVSIGGIFA 1045

  Fly   828 STTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLC 892
            |..||..:.|.|.|:.|.||...|||.::|||||:|..||.::|.|:...|....:::|.|:::.
  Rat  1046 SRRLHLDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIIL 1110

  Fly   893 IINVWYILATVF--LVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQK 955
            :...  |.|.:.  |.:|::.::.||:::||.:||||:|:|||:|||.:.:|.|::.||||..|:
  Rat  1111 LATP--IAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQE 1173

  Fly   956 ELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCV--CVVYIAVITLSFFLFSPE--NGGDVGLAI 1016
            ..|.:.|...|.:...||..:..:|.....|:||  |:|..|.:   |.:.|..  :.|.|||::
  Rat  1174 RFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAAL---FAVISRHSLSAGLVGLSV 1235

  Fly  1017 TQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDL 1081
            :.::.:|..:.|.:|.|:|:|..:.||||:.||.:.|.|..::.: ...||..||..|::.|.|.
  Rat  1236 SYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEASWQIQ-ETAPPSTWPHSGRVEFRDY 1299

  Fly  1082 SLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYN-EGAILIDRRDTNDL 1145
            .|:|..|  .|.||:.:|:.|||.||||||||||||||||...|||::.: ||.|:||..:...:
  Rat  1300 CLRYRED--LDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKI 1362

  Fly  1146 GLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEG 1210
            |||:||.||:||||:||||||::|.|||||.:|||.::|.:||...||..|:.||..|..:.:||
  Rat  1363 GLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEG 1427

  Fly  1211 GTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTV 1275
            |.|.|||||||||||||:||:.:|||:|||||.||.:||.|||:|||.:|:|.|||||||||:|:
  Rat  1428 GENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTI 1492

  Fly  1276 MDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            ||..:|:|:|.|:..|.|:|.|||  .::.||:||.|..|
  Rat  1493 MDYTRVIVLDKGEIRECGAPSELL--QQRGVFYSMAKDAG 1530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	483/1388 (35%)
		ABC_membrane	98..367	CDD:294371	86/282 (30%)
		ABCC_MRP_domain1	443..643	CDD:213217	92/201 (46%)
		ABC_membrane	799..1027	CDD:294371	77/233 (33%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	129/221 (58%)
Abcc1	NP_071617.2	MRP_assoc_pro	7..1531	CDD:188098	490/1405 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345022
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660