DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and Cftr

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_006236159.1	Gene:	Cftr / 24255	RGDID:	2332	Length:	1530	Species:	Rattus norvegicus

Alignment Length:	1467	Identity:	431/1467 - (29%)
Similarity:	728/1467 - (49%)	Gaps:	198/1467 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEK 71
            |.:.::|.||::..|.|.|.:..|...||.:..|:.:|:|:|.....:|||..||...|::|
  Rat    53 DIMQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSDSADHLSEKLEREWDRE--- 114

  Fly    72 KRKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKA 136
             :..||.|.|:.|....|.||....|::|::.|: .:..||:.||.::|.| |..|.| :.....
  Rat   115 -QASKKKPQLIHALRRCFVWRFVFYGVLLYLGEV-TKAVQPVLLGRIIASY-DPDNTE-ERSIAI 175

  Fly   137 YLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLIS 201
            || .:|:.|......|.:||.:.|:.||||:.||||.|:||:|.|:||...|...:|||:::|:|
  Rat   176 YL-GIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLISLLS 239

  Fly   202 NDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLK 266
            |::.:.|..:...:::|:.|:::.::..|::..:..|||.|:.::::.:..||.|||.....|.|
  Rat   240 NNLNKFDEGLALAHFIWIAPLQVVLLMGLLWDLLQFSAFCGLGLLIVLVIFQAILGKMMVKYRDK 304

  Fly   267 TALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTR 331
            .|.:.:||:.:.:|:|..|..:|.|.||....|:|..:|.:|:...|...|:|....|...|...
  Rat   305 RAAKINERLVITSEVIDNIYSVKAYCWESAMEKIIESLREEELKMTRRSAYMRFFTSSAFFFSGF 369

  Fly   332 ISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEE 396
            ..||:|::.:.::..:: ..|.|...::..:||.::|..||..:..:.:.|..||:||.|:..:|
  Rat   370 FVVFLSVLPYTVINGIV-LRKIFTTISFCIVLRMSVTRQFPTAVQIWYDSLGMIRKIQDFLQTQE 433

  Fly   397 TKVRDKSEDLDEQKLGKAGLIAEPTVA-------------QTTGVLKPSSRRTSEAEHSIVISKL 448
            .||.       |..|...||:.|...|             |    |....|:||..|:.:..|.|
  Rat   434 YKVL-------EYNLMFTGLVMENVTAFWEEGFQELLEKVQ----LNNDDRKTSNGENHLSFSHL 487

  Fly   449 KAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQ 513
            ....:.     .|.||:|..|..:::|:.|..|:||:||:..:||||....|.:|.:|.:|::||
  Rat   488 CLVGNP-----VLKNINLNIKKGEMLAITGSTGAGKTSLLMLILGELEASEGIIKHSGRVSFSSQ 547

  Fly   514 EPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISL 578
            ..|:..||:::||:||:..|::||::|||.|.|:.|.......|.|::||.|.:|||||:|||||
  Rat   548 ISWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQEDITKFAEQDNTVLGEGGVTLSGGQRARISL 612

  Fly   579 ARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGK 643
            |||||:.||:||||.|...:|......:|:.|:...:..:..:|||.:::.|::||.|:|:.:|.
  Rat   613 ARAVYKDADLYLLDSPFGYLDVLTEEQIFESCVCKLMASKTRILVTSKMEQLKKADKILILHEGS 677

  Fly   644 ISAMGTYESMAKSGLDF------------------AQMLTDPSKK---DEGA------------- 674
            ....||:..:.....||                  :.:||:..::   |:.:
  Rat   678 SYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTETLRRFSVDDASTTWNKAKQSFRQT 742

  Fly   675 GDAPDKK----------------------SLSRQNSKLRDR---------HGSI----SSMESAA 704
            |:..:|:                      |:..::..|::|         ||..    |:|.:|.
  Rat   743 GEFGEKRKNSILSSFSSVKKISIVQKTPLSIEGESDDLQERRLSLVPDSEHGEAALPRSNMITAG 807

  Fly   705 ESL-----------------AAESPMQTQEGRVE-----GRIGMK-------------------- 727
            .:.                 :..|.:|.....:.     .||.:|
  Rat   808 PTFPGRRRQSVLDLMTFTPSSVSSSLQRTRASIRKISLAPRISLKEEDIYSRRLSQDSTLNITEE 872

  Fly   728 ------------------------LYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNK 768
                                    .|.:||..: .|||.|. .:|:...::.....:|: .|:.|
  Rat   873 INEEDLKECFFDDMVKIPTVTTWNTYLRYFTLH-RGLFAVL-IWCVLVFLVEVAASLFV-LWLLK 934

  Fly   769 NGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHN 833
            |..........::........|.:.:.....|.:.|:..:::..||.|.:...:..:.:|..||.
  Rat   935 NNPVNGGNNGTKIANTSYVVVITSSSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHR 999

  Fly   834 TMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWY 898
            .|...:..|.|..||...:|.||||||||:..:|:.||..:.|.:|:...:||.::|:..:..:.
  Rat  1000 KMLHSILHAPMSTFNKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLLFIVVGAIIVVSALQPYI 1064

  Fly   899 ILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDN 963
            .||||..:.||.|||.::|.||:.:|:||:..||||::||..||.||.|:|||..|......|..
  Rat  1065 FLATVPGLAVFILLRAYFLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHK 1129

  Fly   964 YQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSFFLFSPENGGDVGLAITQAMGMTGMVQW 1028
            ..::|::.::|:|||.|.|...:|.:.|::..|:|....|.:.|..|..|:.:|.||.:...:||
  Rat  1130 ALNLHTANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEGEGTTGIILTLAMNIMSTLQW 1194

  Fly  1029 GMRQSAELENTMTAVERVVEYEDLEPEGDF----------ESKPNK--------KPPKDWPEDGK 1075
            .:..|.:.::.|.:|.||.::.|::.|...          |..||.        |....||..|:
  Rat  1195 AVNSSIDTDSLMRSVSRVFKFIDIQTEESICTKIMKELHSEDSPNALVIKNEHVKKCDTWPSGGE 1259

  Fly  1076 IVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNEGAILIDRR 1140
            :|..||::||..|..|  :|.:::.:|...::||::||||:|||:|::|..|:...:|.|.||..
  Rat  1260 MVVKDLTVKYVDDGNA--ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGEIQIDGV 1322

  Fly  1141 DTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQS 1205
            ..|.:.|.:.|....:|.|:..:||||.|.||||..::.|.::|:..::|.||.|:...|..|..
  Rat  1323 SWNSMTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWRDEEIWKVADQVGLKSVIEQFPGQLNF 1387

  Fly  1206 KISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAH 1270
            .:.:||...|.|.:||:||||::|.:.:|:::||.:||:||.|..:|:..:|..|..|||:...|
  Rat  1388 TLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSANLDPITYQVIRRVLRQAFAGCTVVLCEH 1452

  Fly  1271 RLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVF 1307
            |:..::|..:.||::.|...::.|...||  |||.||
  Rat  1453 RIEAMLDCQRFLVIEQGNVWQYESLQALL--SEKSVF 1487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	424/1453 (29%)
		ABC_membrane	98..367	CDD:294371	82/268 (31%)
		ABCC_MRP_domain1	443..643	CDD:213217	78/199 (39%)
		ABC_membrane	799..1027	CDD:294371	79/227 (35%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	79/220 (36%)
Cftr	XP_006236159.1	CFTR_protein	55..1518	CDD:273530	430/1465 (29%)
		ABC_membrane	139..357	CDD:294371	73/221 (33%)
		ABCC_CFTR1	444..724	CDD:213258	95/288 (33%)
		CFTR_R	693..898	CDD:291094	20/204 (10%)
		ABC_membrane	915..1196	CDD:279056	87/281 (31%)
		P-loop_NTPase	1258..1518	CDD:304359	87/234 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345084
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950