Protein Alignment Mrp5 and Abcc4

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_001028508.2
• Gene: Abcc4 / 239273
• MGIID: 2443111
• Length: 1325
• Species: Mus musculus
• Alignment Length: 1350
• Identity: 610/1350 - (45%)
• Similarity: 860/1350 - (63%)
• Gaps: 87/1350 - (6%)

  Fly     8 ELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKK 72
            |:..||.:.:|:.|.:.|.:..|.|..|.|:.|:|:|::..|.|.||.|||.:|...|:||:.:.
Mouse     7 EVKPNPLQDANLCSRVFFWWLNPLFKTGHKRRLEEDDMFSVLPEDRSKHLGEELQRYWDKELLRA 71

  Fly    73 RKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAY 137
            :|..:.|||.||.:..: |:...:..:..::|.|.||.||||||.::.|:......:......||
Mouse    72 KKDSRKPSLTKAIIKCY-WKSYLILGIFTLIEEGTRVVQPLFLGKIIEYFEKYDPDDSVALHTAY 135

  Fly   138 LYALGVILTSACNVLFMHPYMLGMFHI---GMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNL 199
            .||   .:.|.|.::....:.|..:|:   ||:.|:||..||||||||||.:|:|.||.||:|||
Mouse   136 GYA---AVLSMCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNL 197

  Fly   200 ISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLR 264
            :||||.:.|...|.:::||.||::...:|.|::.|||||...|:||:::.:|||:.:||..|.||
Mouse   198 LSNDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWVEIGISCLAGLAVLVILLPLQSCIGKLFSSLR 262

  Fly   265 LKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFV 329
            .|||..||.|:|.|||:|:|:::|||||||..|:.:|..:|.||::.|...:|:||...:.....
Mouse   263 SKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLIANLRKKEISKILGSSYLRGMNMASFFIA 327

  Fly   330 TRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLH 394
            .::.:||:...:||||..:||...||....|..:|.|:|::||..|.:.:|.:||||||:.|:|
Mouse   328 NKVILFVTFTSYVLLGNEITASHVFVAMTLYGAVRLTVTLFFPSAIERGSEAIVSIRRIKNFLL- 391

  Fly   395 EETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDN 459
                       |||....||.:                   .|:.:..:.:....|.||:.....
Mouse   392 -----------LDELPQRKAHV-------------------PSDGKAIVHVQDFTAFWDKALDSP 426

  Fly   460 TLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQ 524
            ||..:|...:|.:|:||:||||:|||||:.||||||.|.||.|.|:|.::|.||:||:|:||||.
Mouse   427 TLQGLSFIARPGELLAVVGPVGAGKSSLLSAVLGELPPASGLVSVHGRIAYVSQQPWVFSGTVRS 491

  Fly   525 NILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIY 589
            |||||...:|.||..|:|.|||::|.:||...|.|::|:|||:||||||||::||||||:.||||
Mouse   492 NILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIY 556

  Fly   590 LLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMA 654
            ||||||||||..||:|||..|:...|.|:|.:|||||||:|:.|..|:|:..|::...|||....
Mouse   557 LLDDPLSAVDAEVGKHLFQLCICQALHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFL 621

  Fly   655 KSGLDFAQMLTDPSKKDEGA--GDAPDKKSLSRQNSKLRDRHGSISSMESAAESLAAESP----- 712
            |||:||..:|   .|::|.|  ..||...:|.::...    ..||.|.:|:..||...:|
Mouse   622 KSGVDFGSLL---KKENEEAEPSTAPGTPTLRKRTFS----EASIWSQQSSRPSLKDGAPEGQDA 679

  Fly   713 -----MQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFF--CIGAQVLASGGDIFLSYWVNKNG 770
                 :|.:|.|.|||||.|.||.||.|.....||:|...  .:| ||.....|.:||:|.||.|
Mouse   680 ENTQAVQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNMVG-QVFYVLQDWWLSHWANKQG 743

  Fly   771 EAERDTFMARLRRAFPETRINAD---TDPVDIYYFTGINVSV----IIFSLVRSMLFFYLAMRSS 828
                         |...|| ||:   |:.:|:.::.||...:    ::|.:.||:|.||:.:.:|
Mouse   744 -------------ALNNTR-NANGNITETLDLSWYLGIYAGLTAVTVLFGIARSLLVFYILVNAS 794

  Fly   829 TTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCI 893
            .||||.||:.:.:|.:.||:.||.||||||||||:|.:|::||...:|.:|..|.:|.::.|...
Mouse   795 QTLHNRMFESILKAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAA 859

  Fly   894 INVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELI 958
            :..|.::..|.|.:||.:||.::|.|||||||||:.||||::||||:||.||.||||:.|::...
Mouse   860 VIPWILIPLVPLSVVFLVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQ 924

  Fly   959 AEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITL-SFFLFSPENGGDVGLAITQAMGM 1022
            ..||.:||:||..:::||.|||.|...||.:|.:::.|:.. |..|....|.|.||||::.|:.:
Mouse   925 ELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAIFVIVVAFGSLVLAKTLNAGQVGLALSYALTL 989

  Fly  1023 TGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFP 1087
            .||.||.:|||||:||.|.:||||:||.|||.|..:|.|  |:||..||.:|.||||:::..|..
Mouse   990 MGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWECK--KRPPPGWPHEGVIVFDNVNFTYSL 1052

  Fly  1088 DKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNEGAILIDRRDTNDLGLHDLRS 1152
            |  ...||:.|...|:..|||||||||||||||||:||||||..||.|.||:..|.::||||||.
Mouse  1053 D--GPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRK 1115

  Fly  1153 KISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVG 1217
            |:||||||||||:||||.|||||:|::|.:||.:||||:||:.:.|||..:.::::|.|:|||||
Mouse  1116 KMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWRALEEVQLKEAIEDLPGKMDTELAESGSNFSVG 1180

  Fly  1218 QRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVL 1282
            ||||||||||||:.||||::|||||||||:||.|||..||.||..||||||||||:|::||||::
Mouse  1181 QRQLVCLARAILKNNRILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIM 1245

  Fly  1283 VMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTGDSTFDALLKVAQKVGLR 1332
            |:|:|:..|:..|:.||...| .:|:.||:|.|.....||.:.|::|..|
Mouse  1246 VLDSGRLKEYDEPYVLLQNPE-SLFYKMVQQLGKGEAAALTETAKQVYFR 1294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	579/1260 (46%)
Abcc4	NP_001028508.2	PLN03130	12..1284	CDD:215595	603/1333 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	657..690		8/32 (25%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:O15439	1322..1325