Protein Alignment CG4562 and ABCB9

DIOPT Version :9

• Sequence 1: NP_001262747.1
• Gene: CG4562 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_062571.1
• Gene: ABCB9 / 23457
• HGNCID: 50
• Length: 766
• Species: Homo sapiens
• Alignment Length: 612
• Identity: 142/612 - (23%)
• Similarity: 271/612 - (44%)
• Gaps: 123/612 - (20%)

  Fly   741 FIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGI 805
            |:|.|.|.:   ::|:.|:.||.|:..               ||.....|....|.        .
Human   187 FLVAASFFL---IVAALGETFLPYYTG---------------RAIDGIVIQKSMDQ--------F 225

  Fly   806 NVSVIIFSL----------VRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFS 860
            :.:|:|..|          :|..:|..:..|.:..|.|.:|:.:......||:.|.:|.:::|.:
Human   226 STAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLT 290

  Fly   861 KDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVF-----LVIVFYLLRVFYLSTS 920
            .|...|.:::...:...::..:.:.|:||.:..:: |.:....|     :::|..:...:|...|
Human   291 SDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLS-WQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354

  Fly   921 RDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNY----QDMH-----SSGYYMFL 976
            ::|:  .|:.|:.  :....:::.:.|:|:|..::|   |.:.|    |.::     .:..||:.
Human   355 KEVQ--NALARAS--NTAEETISAMKTVRSFANEEE---EAEVYLRKLQQVYKLNRKEAAAYMYY 412

  Fly   977 ATSRAFGYWLDCVCVVY----------------IAVITLSFFLFSPENGGDVGLAITQAMGMTGM 1025
            .........:..|.::|                ||.|...|.|      ||       .|...|.
Human   413 VWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVL------GD-------CMESVGS 464

  Fly  1026 VQWGMRQSAELENTMTAVERVVEYEDLEP----EGDFESKPNKKPPKDWPE--DGKIVFDDLSLK 1084
            |..|:.|.      :.|.|:|.|:.|.:|    :|...           |:  :|::.|::::..
Human   465 VYSGLMQG------VGAAEKVFEFIDRQPTMVHDGSLA-----------PDHLEGRVDFENVTFT 512

  Fly  1085 YFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNEGA-ILIDRRDTNDLGLH 1148
            | ..:....||::::.::...:...:||.:|:||||.:|.|......||. :|:|.:..:.....
Human   513 Y-RTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHK 576

  Fly  1149 DLRSKISIIPQEPVLFSGTMRYNLD------PFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKI 1207
            .|...||::.||||||:.::..|:.      ||:     .:.|:.::......:.:|..|..::.
Human   577 YLHRVISLVSQEPVLFARSITDNISYGLPTVPFE-----MVVEAAQKANAHGFIMELQDGYSTET 636

  Fly  1208 SEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRL 1272
            .|.|...|.||:|.|.:|||::|...:|::||||:.:|.:::.|||..|....:..|||.|||||
Human   637 GEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRL 701

  Fly  1273 HTVMDSDKVLVMDAGKAVEFGSPFELL 1299
            .||..:..::|:|.|:.|:.|:..:||
Human   702 STVEHAHLIVVLDKGRVVQQGTHQQLL 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	142/612 (23%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217
		ABC_membrane	799..1027	CDD:294371	47/267 (18%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	69/227 (30%)
ABCB9	NP_062571.1	3a01208	44..738	CDD:273363	142/612 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910