Protein Alignment Mrp5 and Abcc10

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_001334325.1
• Gene: Abcc10 / 224814
• MGIID: 2386976
• Length: 1526
• Species: Mus musculus
• Alignment Length: 1396
• Identity: 441/1396 - (31%)
• Similarity: 695/1396 - (49%)
• Gaps: 189/1396 - (13%)

  Fly    21 SSLMFCFAMPTFFKGRKKTLDE-NDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKKKKTPSLLKA 84
            |...:.:..|...:|.:..|.: .|..|..:......|.....|.|          |:...|.:|
Mouse   223 SRFSYAWLAPLLARGVRGELQQPRDTCRLPRRLHPAFLARVFQAHW----------KEGAQLWRA 277

  Fly    85 SMNVFGWRLAGLGLVLFI-LEIGFRVTQPLFLGGLVAYYADASNQEGDNQ-TKAYLYALGVILTS 147
            ....||.....|||:..: ..:||  :.||.|..||.:.     :||... :...||.||:...:
Mouse   278 LYRAFGCCYLALGLLKMVGTMLGF--SGPLLLSLLVGFL-----EEGQEPLSHGLLYVLGLAGGT 335

  Fly   148 ACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVI 212
            ..:.:..:.|...:..:.::||:|:.|.:|||||:|..:.   ...|:|:||:..|..||
Mouse   336 VISAVLQNQYGYEVRKVTLQARVAVLSTLYRKALKLGPSR---PPTGEVLNLLGTDSERL----- 392

  Fly   213 HMNY------LWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRT 271
             :|:      .|..|:::.|..||:|:::|::...|:.:.||.:|:...:..:......:.....
Mouse   393 -LNFAGSFHEAWGLPLQLAITLYLLYQQVGMAFLAGLVLALLLVPVNKVIATRIMASNQEMLRHK 456

  Fly   272 DERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGT---LQSFIMFVTRIS 333
            |.||::|.|::|||:|||.:.||......:...||||:..:|.:.|:...   |.:.:..|..|:
Mouse   457 DARVKLMTELLSGIRVIKFFRWEQALGDRVKACRTKELGRLRVIKYLDAACVYLWAALPVVICIT 521

  Fly   334 VFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETK 398
            :|::   :||:|..|||.|.|...|...:|...:. .||..|:...|..||:.|||.|:
Mouse   522 IFIT---YVLMGHQLTATKVFTALALVRMLILPLN-NFPWVINGLLESKVSLDRIQRFL------ 576

  Fly   399 VRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDN 463
                  ||.... .:|....:|          |:...|:...|..:.|     ||..........
Mouse   577 ------DLPSYS-PEAYYSPDP----------PAEPSTALELHEALFS-----WDPIGASQKTFI 619

  Fly   464 ISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGT---LSYASQEPWLFTGTVRQN 525
            ..|:.|...||.::|.||.|||||:.|:.|||:...|.|.|:..   ...|:||||:...|:|.|
Mouse   620 SHLQVKKGMLVGIVGKVGCGKSSLLAAITGELHRLCGWVAVSELSKGFGLATQEPWIQCATIRDN 684

  Fly   526 ILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYL 590
            ||||...|...||.|::.|||..|..:||..|:|.|||:|.:|||||:|||:||||||::..:||
Mouse   685 ILFGKTFDAQLYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKALYL 749

  Fly   591 LDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAK 655
            |||||:|||..|..||..:|:.|.|.....||.||:.::||:|||:::|:.|::...|....:
Mouse   750 LDDPLAAVDADVANHLLHRCILGVLSHTTRLLCTHRTEYLERADVVLLMEAGQLVRTGPPSEI-- 812

  Fly   656 SGLDFAQML-TDPSKKDEGA--GDAPDKKSLSRQNSKLRDRHGSISSMESAAESLAAESP----M 713
              |...|.: |..::|::.|  |.:|....|.|                :..|.|..|..    :
Mouse   813 --LPLVQAVPTAWAEKEQVATSGQSPSVCDLER----------------TTEEELEVEQSTCGCL 859

  Fly   714 QTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVN-----KNGEAE 773
            ..:|.:.||.:.:.:|:.|:.|.|.||........:..|...:|.|.:|::|::     :||..|
Mouse   860 VQEESKSEGAVALHVYRAYWRAMGSGLAAAILVSLLLMQATRNGADWWLAHWLSQLKAGRNGSRE 924

  Fly   774 RDT---------FMARLRRAFP--------ETRIN--ADTDPVDIYYF-------TGINVSVIIF 812
            ...         |..||....|        .|.::  |.....|::::       .|:|   .:.
Mouse   925 DPASCSPGSTALFSPRLLLFSPGNLYTPLLSTPLHKAASNGTADVHFYLIVYATIAGVN---SLC 986

  Fly   813 SLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDV 877
            :|:|::||...|::::.:||:.:...:..|.:.|:::.||||:|||||.|:..||:.||.::..:
Mouse   987 TLLRAVLFAAGALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNIL 1051

  Fly   878 MQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASL 942
            :...:.::|::.||.....|.:|....|..|:|.::.:|.::.|:::||.::|.||:||||:.:|
Mouse  1052 LANSVGLLGLLAVLGSGLPWLLLLLPPLSFVYYSVQGYYRASFRELRRLGSLTWSPLYSHLADTL 1116

  Fly   943 NGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLD-------CVCVVYIAVITLS 1000
            .||..:||.||......|.....:::....:...||.:    |||       ...|..||.|.|.
Mouse  1117 AGLPVLRAAGATYRFEEENQRLLELNQRCQFASYATMQ----WLDIRLQLMGAAVVSAIAGIALV 1177

  Fly  1001 FFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKK 1065
            .......|.|.|||.::.|:.:||::...:....:.|..|.:|||:.||....|: :..|:|.:.
Mouse  1178 QHQQGLANPGLVGLVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDVPQ-EPHSQPLQS 1241

  Fly  1066 PPK---DWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFR 1127
            |.:   .|...|.:.|.|:.|.|.|  .....|..:...:|..||:|||||||:|||||...|||
Mouse  1242 PHQQRISWLTQGSVEFQDVVLVYRP--GLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFR 1304

  Fly  1128 -LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVK 1191
             |..|.|.:|:|..||:.|.|.:|||::::|||||.|||||:|.||||...:.|..||::||:..
Mouse  1305 LLEPNAGRVLLDNVDTSQLELAELRSQLAVIPQEPFLFSGTIRENLDPQGLHEDRALWQALEQCH 1369

  Fly  1192 LKQVV------------------------ADLPSGLQSKISEGGTNFSVGQRQLVCLARAILREN 1232
            |.:|.                        |.|..||..::.|.|.|.|:|||||:|||||:|.:.
Mouse  1370 LSEVAVAMGESQACQRSQREAKNGHWQCSALLTGGLDGELGERGQNLSLGQRQLLCLARALLTDA 1434

  Fly  1233 RILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFE 1297
            :||.:|||||:||.:||.|:|.||..:|.:.|||||||||:|:::||:|||:.||:.||..||
Mouse  1435 KILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSP-- 1497

  Fly  1298 LLTTSEKKVFHSMVKQTGDSTFDALLKVAQK 1328
                       |.::....|.|..||:.:|:
Mouse  1498 -----------SALRNQPHSLFQQLLQSSQQ 1517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	426/1322 (32%)
Abcc10	NP_001334325.1	MRP_assoc_pro	203..1503	CDD:188098	436/1380 (32%)