DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4562 and Tap2

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_035660.3	Gene:	Tap2 / 21355	MGIID:	98484	Length:	702	Species:	Mus musculus

Alignment Length:	617	Identity:	151/617 - (24%)
Similarity:	280/617 - (45%)	Gaps:	85/617 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   708 AAESPMQTQEGRVEGRIGMKLYKKYFGANGYGL-FIVFAFFCIGAQVLASGGDIFLSYWVNK--- 768
            |..||...|| :..|:....|.|:....:...| |::.|||.:   |:|..|:..:..:..:
Mouse   117 AVLSPAGVQE-KEPGQENRTLMKRLLKLSRPDLPFLIAAFFFL---VVAVWGETLIPRYSGRVID 177

  Fly   769 --NGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTL 831
              .|:.:.|.|.:.                  |::....:|.....:..|...|.:...|.:..:
Mouse   178 ILGGDFDPDAFASA------------------IFFMCLFSVGSSFSAGCRGGSFLFTMSRINLRI 224

  Fly   832 HNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINV 896
            ...:|..:.|..:.||....:|.:.:|.|.|...:...||.....:::..:.:||:...:..::.
Mouse   225 REQLFSSLLRQDLGFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGLYFFMLQVSP 289

  Fly   897 -WYILATVFLVIVFYLLRVFYLSTSRDVKRL-EAVTRSPIYSHLSASLNGLATIRAFGAQKELIA 959
             ...|:.:.|.:.....:|:.......:|.: :||.::.  ..:..::.||.|:|:|||:::.::
Mouse   290 RLTFLSLLDLPLTIAAEKVYNPRHQAVLKEIQDAVAKAG--QVVREAVGGLQTVRSFGAEEQEVS 352

  Fly   960 EFDN----------YQDMHSSGYYMFLATSRAFGYW---LDC-VCVVYIAVIT----LSFFLFSP 1006
            .:..          .:|:... .|:.:....|.|..   |:| |..:....:|    |||.|:..
Mouse   353 HYKEALERCRQLWWRRDLEKD-VYLVIRRVMALGMQVLILNCGVQQILAGEVTRGGLLSFLLYQE 416

  Fly  1007 ENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPP---- 1067
            |    ||..:...:.|.|          ::.:.:.|.|:|..|.|        .|||...|
Mouse   417 E----VGQYVRNLVYMYG----------DMLSNVGAAEKVFSYLD--------RKPNLPQPGILA 459

  Fly  1068 KDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNE 1132
            ..|.| |::.|.|:|..| |.:....||:.|...:.......:||..|:|||: :.||.:..|..
Mouse   460 PPWLE-GRVEFQDVSFSY-PRRPEKPVLQGLTFTLHPGTVTALVGPNGSGKST-VAALLQNLYQP 521

  Fly  1133 --GAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLD-PFDEYSDAKLWESLEEVKLKQ 1194
              |.:|:|.....:...|.|..::.::.||||||||:::.|:. ...:..||::..:.:......
Mouse   522 TGGQLLLDGEPLTEYDHHYLHRQVVLVGQEPVLFSGSVKDNIAYGLRDCEDAQVMAAAQAACADD 586

  Fly  1195 VVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNK 1259
            .:.::.:|:.::|.|.|...:|||:|.:.:|||::|..|:|::||||:.:|.|.:..:|.. |::
Mouse   587 FIGEMTNGINTEIGEKGGQLAVGQKQRLAIARALVRNPRVLILDEATSALDAQCEQALQNW-RSQ 650

  Fly  1260 FKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVE 1291
             .|.|:|.||||||||.::|:|||:..|:.||
Mouse   651 -GDRTMLVIAHRLHTVQNADQVLVLKQGRLVE 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	151/617 (24%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217
		ABC_membrane	799..1027	CDD:294371	47/247 (19%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	74/221 (33%)
Tap2	NP_035660.3	3a01208	1..696	CDD:273363	151/617 (24%)
		ABC_membrane	155..415	CDD:279056	50/283 (18%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03519	300..388		15/90 (17%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03519	413..432		6/32 (19%)
		P-loop_NTPase	456..679	CDD:304359	74/227 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000