DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and Abcc9

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_035641.1	Gene:	Abcc9 / 20928	MGIID:	1352630	Length:	1546	Species:	Mus musculus

Alignment Length:	1358	Identity:	413/1358 - (30%)
Similarity:	689/1358 - (50%)	Gaps:	191/1358 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 KEVEKKRKKK------KTPSLLKASMNVFGWRLAGLGLVLFILE-IGFRVTQPLFLGGLVAYYAD 124
            ||..:::|||      :|||:..|....||..:.......::.: :||  ..||.:.|:|....:
Mouse   265 KEAYEEQKKKAADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGF--AGPLCISGIVQRVNE 327

  Fly   125 ASNQEGDN-----QTKAYL---YALGVILTSACNVLFMHPYMLGMFHI----GMKARIAMTSMIY 177
            .:|...:.     .:|.:|   :.|.|:|..|  ::....::...:::    |:..|.|:.:|||
Mouse   328 KTNTTREMFPETLSSKEFLENAHVLAVLLFLA--LILQRTFLQASYYVTIETGINLRGALLAMIY 390

  Fly   178 RKALRLSRT--ALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAF 240
            .|.||||.:  ::|:.|:||:.||::.:..:|...:.....||..||:|.:...|:|..:|.||.
Mouse   391 NKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSAL 455

  Fly   241 FGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVR 305
            .|.||::|..|:|.::..|.:..:..|...:.||::..|||:.||:::|:||||..|.|.:...|
Mouse   456 VGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETR 520

  Fly   306 TKEMNAIRNVNYIRGTLQSFIMFVTRISVFVS--------LVGFV----LLGKLLTAEKAFVITA 358
            .||::          :|::|.:: |.:|:|::        |..||    ..|..|...:||...:
Mouse   521 MKELS----------SLKTFALY-TSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLS 574

  Fly   359 YYNILRNTMTVYFPMG-ISQFA-ELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPT 421
            .::||   :|..|.:. :.:|| :.::|::::..|:|.:|.       ..|..:.|:..|..|..
Mouse   575 LFHIL---VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEI-------GEDSWRAGEGTLPFESC 629

  Fly   422 VAQTTGVLKPSSR-----------------RTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFK 469
            ...|....||.:|                 |.:|.| .|.|......:...:...||.||.::..
Mouse   630 KKHTGVQSKPINRKQPGRYHLDSYEQARRLRPAETE-DIAIKVTNGYFSWGSGLATLSNIDIRIP 693

  Fly   470 PRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNG-----------------TLSYASQEPWL 517
            ..||..::|.||.|||||:.|:|||:....|.|..|.                 :::||:|:|||
Mouse   694 TGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWL 758

  Fly   518 FTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAV 582
            ...||.:||.||.|.::.||:.|...|:|:.|.:|||:.|:|.:||||.:|||||:.||.:|||:
Mouse   759 LNATVEENITFGSPFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARAL 823

  Fly   583 YRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREE--IVLLVTHQLQFLEQADVIVIMDKGKIS 645
            |:..:|..||||.||:|.|:..||..:.:..||:::  .|:||||:||:|..||.|:.|..|.:.
Mouse   824 YQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVL 888

  Fly   646 AMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKL-RDRHGSISSME-----SAA 704
            ..||.:.:....::..:..               |..::||:.:| :|.....:::|     .|.
Mouse   889 REGTLKDIQTKDVELYEHW---------------KTLMNRQDQELEKDMEADQTTLERKTLRRAM 938

  Fly   705 ESLAAESPMQTQEGRVEG------------RIGMKLYKK----YFGANGYGLFIVFAFFCIGAQV 753
            .|..|::.|:.::...|.            |:..|:..|    |..:.|:.|.    |..|.:::
Mouse   939 YSREAKAQMEDEDEEEEEEEDEEDNMSTVMRLRTKMPWKTCWWYLTSGGFFLL----FLMIFSKL 999

  Fly   754 LASGGDIFLSYW---------VNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINV-- 807
            |.....:.:.||         :|..|:|::                        .:|..|.::
Mouse  1000 LKHSVIVAIDYWLATWTSEYSINHPGKADQ------------------------TFYVAGFSILC 1040

  Fly   808 -SVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILP 871
             :.|...||.|:...::.:.::..||:.:...:....:.||:|.|.|.||||||.|...:|:.:|
Mouse  1041 GAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIP 1105

  Fly   872 SVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYS 936
            ..:..:.:..|..:..:.::......:::|...|.:.||.::.::...|:|::.|:..|:.|:..
Mouse  1106 PTLESLTRSTLLCLSAIGMISYATPVFLVALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLC 1170

  Fly   937 HLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDC------VCVVYIA 995
            |.|.:..||.|||||..:...........|.::..|....|.:|    ||:.      .|:|..|
Mouse  1171 HFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANR----WLEVRTDYLGACIVLTA 1231

  Fly   996 VITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFES 1060
            .|.   .:....|.|.|||.:..|:.:|..:.|.:|..|:||..|.||::|..:..:|.|....:
Mouse  1232 SIA---SISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGT 1293

  Fly  1061 KPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINAL 1125
            ....:.|:.||::|:|...||.::|  :.....||:.:...|:..:||||.||||:|||||..|.
Mouse  1294 MDPSQVPEHWPQEGEIKIHDLCVRY--ENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAF 1356

  Fly  1126 FRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEE 1189
            ||: ...:|.|:||..|.:.|.||.|||::|||.|:|:||||::|:||||..:.:|.:|||:||.
Mouse  1357 FRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEI 1421

  Fly  1190 VKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQT 1254
            .:||.:|..||.||.:.::|||.|||||||||.|||||.:|::.||:||||||::|..|:.::|.
Mouse  1422 AQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQK 1486

  Fly  1255 TIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVK 1312
            .:...|.|.||:|||||:||::.:|.|:||..|..:|:.:| |.|...|..||.|.|:
Mouse  1487 VVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTP-ESLLAQEDGVFASFVR 1543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	407/1344 (30%)
		ABC_membrane	98..367	CDD:294371	80/295 (27%)
		ABCC_MRP_domain1	443..643	CDD:213217	87/218 (40%)
		ABC_membrane	799..1027	CDD:294371	58/236 (25%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	108/221 (49%)
Abcc9	NP_035641.1	MRP_assoc_pro	23..1543	CDD:188098	412/1356 (30%)
Abcc9	NP_035641.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..964		3/22 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841668
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.640