DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and Abcc8

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_036008753.1	Gene:	Abcc8 / 20927	MGIID:	1352629	Length:	1597	Species:	Mus musculus

Alignment Length:	1442	Identity:	435/1442 - (30%)
Similarity:	698/1442 - (48%)	Gaps:	238/1442 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 MPTFFK-GRKKTLDENDL------YRALQEHRSDHLGSKLSAAWEKEVEKKRKKKK-TPSLLKAS 85
            |..|.| ..:|.:|...:      .|||..::      :|.||::.:..|..:.:: ..::.:|.
Mouse   233 MNAFIKTAHRKPIDLRAIGKLPIAMRALTNYQ------RLCAAFDAQARKDTQSQQGARAIWRAL 291

  Fly    86 MNVFGWRLAGLGLVLFILEIGFRV-------TQPLFLGGLV------------------AYYADA 125
            .:.||.||        :|...||:       ..||.:.|:|                  .|:..:
Mouse   292 CHAFGRRL--------VLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSS 348

  Fly   126 SNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHI----GMKARIAMTSMIYRKALRLSRT 186
            ....|:      .|.|.|:|..|  :|....::...:::    |:..|.|:.:.||.|.:.||.:
Mouse   349 QEFLGN------AYVLAVLLFLA--LLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTS 405

  Fly   187 --ALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLF 249
              ::|:.|.||:.||::.|..:|.........||..||:|.:...|:|..:|:||..|.||::|.
Mouse   406 NLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILL 470

  Fly   250 IPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRN 314
            .|:|.::..|.|..:..|...::||::..||::.||:::|:||||..|...:...|.|||.::|
Mouse   471 APVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEMTRRKEMTSLR- 534

  Fly   315 VNYIRGTLQSFIMFVTRISVF-----------VSLVGFVLLGKL--LTAEKAFVITAYYNILRNT 366
                     :|.:: |.||:|           ::.||.|...|.  .:...||...:.::||
Mouse   535 ---------AFAVY-TSISIFMNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHIL--- 586

  Fly   367 MTVYFPMG--ISQFAELLVSIRRIQTFMLHEETKVRDKS----EDLDEQKLGKAGLI-------A 418
            :|..|.:.  :....:.|||::::..|:  ...::|::.    |...:.:.||...:       .
Mouse   587 VTPLFLLSSVVRSTVKALVSVQKLSEFL--SSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRK 649

  Fly   419 EPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDN------------------TLDNIS 465
            .|...:...:|.|..|.|...:              .:.||                  ||.||:
Mouse   650 RPAREEVRDLLGPLQRLTPSMD--------------GDADNFCVQIIGGFFTWTPDGIPTLSNIT 700

  Fly   466 LKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSV---------------------------- 502
            ::....||..::|.||.|||||:.|.|||:...||:|
Mouse   701 IRIPRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWNSSLPDSEGEDPRYCLRTSNPERETA 765

  Fly   503 -----KVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVG 562
                 :..|.::||||:|||...||.:||.|..|.:|.||:.|::.|:|:.|.::||:.|:|.:|
Mouse   766 ADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIG 830

  Fly   563 ERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREE--IVLLVTH 625
            |||.:|||||:.|||:|||:|:..::..||||.||:|.|:..||....:...||::  .|:||||
Mouse   831 ERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTH 895

  Fly   626 QLQFLEQADVIVIMDKGKISAMGTYESMAKSGLD-FAQMLTDPSKKDEG-------AGDAPD--- 679
            :||:|..||.|:.|..|.|...||.:...:|... |....|..:::|:.       ...||:
Mouse   896 KLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQ 960

  Fly   680 --KKSLSRQNSKLRDRHGSISSMESAAESLAAESPMQTQEGRV---EGRIGMKLYKKYFGANGYG 739
              .:::|.::..|.|        |...|..||||........|   ..:|..:...||..:.|..
Mouse   961 GLPRAMSSRDGLLLD--------EDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGVL 1017

  Fly   740 LFIVFAFFCIGAQVLASGGDIFLSYWVNK-------NGEAERDTFMARLRRAFPETRINADTDPV 797
            |..:..|    :|:|.....:.:.||:.|       ...|.|:..:::      |..::   ..|
Mouse  1018 LLSLLVF----SQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQ------ECALD---QSV 1069

  Fly   798 DIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKD 862
            ....||.:....|...||.|:...:..::.:..||.::...:..|.|.||.|.|.|.||||||.|
Mouse  1070 YAMVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSD 1134

  Fly   863 LGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLE 927
            ...:|:.:||.:..:.:..|..|..:.|:..:...:::|.:.|.:|.|.::.::...|||:::|:
Mouse  1135 CNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLD 1199

  Fly   928 AVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDC---- 988
            ..|:.|:.||.:.::.||.|||||..:.....:...|.|.::.......|.:|    ||:.
Mouse  1200 DTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANR----WLEVRMPG 1260

  Fly   989 -----------VCVVYIAVIT-LSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMT 1041
                       .|||.||..| :|..|....:.|.|||.:|.|:.::..:.|.:|..|::|..:.
Mouse  1261 PAAVLPQEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLG 1325

  Fly  1042 AVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCE 1106
            ||:|:......|.|...........||:||:.|||...:||::|  |.:...||:.:|..|...:
Mouse  1326 AVKRIHTLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRY--DSSLKPVLKHVNALIAPGQ 1388

  Fly  1107 KVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRY 1170
            |:||.||||:||||...|.||: ...||.|:||..|...|.||.|||::|||.|:|||||||:|:
Mouse  1389 KIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRF 1453

  Fly  1171 NLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRIL 1235
            ||||..:.||:.|||:||..:||.||..||.||.:.|:|||.|||.|||||.|||||.:|:..|.
Mouse  1454 NLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIF 1518

  Fly  1236 VMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLT 1300
            :||||||::|..|:.::|..:...|.|.||:|||||:||::.:|.|:|:..|..:||..|.:||:
Mouse  1519 IMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLS 1583

  Fly  1301 TSEKKVFHSMVK 1312
            ..: .||.|.|:
Mouse  1584 QKD-SVFASFVR 1594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	430/1428 (30%)
		ABC_membrane	98..367	CDD:294371	80/312 (26%)
		ABCC_MRP_domain1	443..643	CDD:213217	88/252 (35%)
		ABC_membrane	799..1027	CDD:294371	67/243 (28%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	113/221 (51%)
Abcc8	XP_036008753.1	MRP_assoc_pro	224..1594	CDD:188098	434/1440 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841688
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650