Protein Alignment Mrp5 and mrp-8

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_499598.2
• Gene: mrp-8 / 190710
• WormBaseID: WBGene00003414
• Length: 1461
• Species: Caenorhabditis elegans
• Alignment Length: 1378
• Identity: 449/1378 - (32%)
• Similarity: 713/1378 - (51%)
• Gaps: 157/1378 - (11%)

  Fly     8 ELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKK 72
            ::.:.|.|||:..|.:.||:..|....|.|:.|....|:...:...|:.|.::..|.::|  ||.
 Worm   172 KIEQTPEEKSSFLSKIFFCWLNPLIRAGAKQPLTNESLHNLNENATSEWLYTRWRAEFDK--EKA 234

  Fly    73 RKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAY 137
            .:|....|::...:.:....:..|.|.....:| .....|:.|..|:.|.:      ..:|..::
 Worm   235 GRKSGETSIVWPFIRIQRATIITLTLARLTADI-VHYLNPILLKQLIDYVS------LHDQPLSF 292

  Fly   138 LYALGVILTSACNV---LFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNL 199
            ..|:..|:.| |:.   |..:..:.||....:..:..:::.|..|.||||.:|..:.|.|:::|.
 Worm   293 GIAIACIMFS-CSTTRSLLQNYQIAGMCRQAVYYQTVLSNAILHKILRLSPSARSNRTAGEILNH 356

  Fly   200 ISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLR 264
            .:.|:..:..||.::..:|..|.::.:...::...:|.:|..||.:|:|||||.....:...:.:
 Worm   357 AAVDIEIIVHSVPYLQNMWSVPFQVTLAMTMLAITLGWAAMAGVCIMILFIPLNLCTSRFIKLSQ 421

  Fly   265 LKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFV 329
            .|.....|||.::.||:::||:|:|:||||..|...||.:|.||:..:|||    ..|...:...
 Worm   422 QKQMKIKDERTKLSNEMLNGIKVVKLYAWEESFEDQINRLRAKEVKMLRNV----CILSRIVDVA 482

  Fly   330 TRISVFVSLVG----FVLLG---KLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRR 387
            ...|.|:..:|    :||..   ..||...|||....:|.||..|.:...: |:...:..||.:|
 Worm   483 NAASPFLVAIGSFTCYVLWSPDENGLTPSVAFVALTIFNQLRQPMRMVANL-INTLVQARVSNKR 546

  Fly   388 IQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKW 452
            ::.|:..||      .|...|..||.|                            ||.......|
 Worm   547 LRQFLNDEE------MERKTEVALGNA----------------------------IVFKNASLNW 577

  Fly   453 DQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWL 517
            ........|.::|...||.||:|::|.||.|||||:.|||.|:....|.|||.|:::|..|..|:
 Worm   578 KGPQNPPVLKDLSATIKPGQLIAIVGSVGGGKSSLLSAVLDEMVLLDGRVKVGGSIAYVPQHSWI 642

  Fly   518 FTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAV 582
            |..|:::|||||..:..:.|..||..|.|:.||......:.|:|||.|.:|||||||||||||||
 Worm   643 FNKTIKENILFGNELSNYFYDQVVGSCQLKTDFRHFQQGENTMVGENGITLSGGQKARISLARAV 707

  Fly   583 YRKADIYLLDDPLSAVDTHVGRHLFDQCM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKIS 645
            |:..|||||||||||||.||||.|||:.:  .|.||.:..:||||.||:.:..|.|.:::.|:|.
 Worm   708 YQDKDIYLLDDPLSAVDAHVGRALFDKVIGPDGLLRSKTRVLVTHNLQYTKYVDTIYVIEDGQIV 772

  Fly   646 AMGTYESMAKSGLDFAQMLTDPSKKDEGAGD-----------------------APDKKS-LSRQ 686
            ..|::|.:|.....|.::.::....||...|                       |.:|.| :.|.
 Worm   773 QHGSFEDIAYVDGPFGRLWSECENSDEDVADEEAESSEASVTPPVPVLENGDNGAIEKSSQIDRT 837

  Fly   687 NSKLRDRHGSISSMESAAESLAAESPMQ-TQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIG 750
            ||     |.|..|.:|..:....|..:: .|.|||:..: .:||.|..|......|::|......
 Worm   838 NS-----HFSEKSRKSEEKPQKVEKNVENVQLGRVKKSV-YQLYIKTMGIFNSSAFLIFFIAHFT 896

  Fly   751 AQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVD---------IYY--FTG 804
            ..::.|   ::||.|.|:|...::.|..:       ...:|: |..||         |.|  |.|
 Worm   897 VMIMRS---LWLSDWSNENAAIKKATLSS-------VDYLNS-TSSVDGPVSVETRLIVYAGFGG 950

  Fly   805 INVSVIIFSLVRSMLFFYL---AMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQV 866
            :.:      |:.::.|..|   ::|:|..||:.:...:..|.:.||:|.|:|||:||.|:||..:
 Worm   951 LEM------LLLALAFTVLTIGSLRASYGLHSPLIHALLVAPISFFDTTPTGRIINRLSRDLDVI 1009

  Fly   867 DEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTR 931
            |::..::.| ..|..|....|:|::.|....:::....|::::|.:.::|:.|||.:||||:..|
 Worm  1010 DKLQDNIRM-CTQTLLNACMILVLISISTPIFLVCAAPLILIYYFVMIYYIPTSRQLKRLESANR 1073

  Fly   932 SPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDC-------V 989
            |||.|.::.|::|.::||||...:..........|..:...|:...::|    ||..       .
 Worm  1074 SPILSTIAESIHGASSIRAFDKTERTTTALSTNVDKFAQCRYLSHMSNR----WLATRLELLGNT 1134

  Fly   990 CVVYI---AVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYED 1051
            ||::.   |.::..:|..:|   |..||:::.|:.:|.::...:|..:|:|:.:.:||||.||:.
 Worm  1135 CVLFASLSATLSTKYFGLTP---GMAGLSVSYALTITEVLNICVRSVSEIESNIVSVERVNEYQK 1196

  Fly  1052 LEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGA 1116
            ||||..:..:.:.:..:.||..|||..|..|::|  .|....||:::::.|||.|::|::||||:
 Worm  1197 LEPEAPWRIEKSLENEEKWPVKGKIELDGFSMRY--RKNLPLVLKNIDLKIEGGERIGVIGRTGS 1259

  Fly  1117 GKSSLINALFRLSYNE-GAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSD 1180
            |||||..||:|:...| |.|.||..:.:.:|||.||||:.|||||||:||||:|:|||||::|||
 Worm  1260 GKSSLTMALYRMIEGESGTIKIDDVEIDTIGLHQLRSKLIIIPQEPVVFSGTLRFNLDPFNQYSD 1324

  Fly  1181 AKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVD 1245
            .::|..||..:|||...:....|...|:|||.|.|||:|||:||.||:||..||:::|||||:||
 Worm  1325 DQIWNCLEICQLKQFAQEDDKTLDRYIAEGGKNMSVGERQLLCLCRALLRGARIVILDEATASVD 1389

  Fly  1246 PQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSM 1310
            ..||.::|..||..|...|.::|||||.|::|||:::|:|||:..||.:|..||...
 Worm  1390 TVTDGIVQRAIRQHFPQSTTISIAHRLDTIVDSDRIVVLDAGRVAEFDTPSNLLLNP-------- 1446

  Fly  1311 VKQTGDSTFDALL 1323
                 ||.:..||
 Worm  1447 -----DSLYSQLL 1454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	426/1297 (33%)
mrp-8	NP_499598.2	MRP_assoc_pro	177..1451	CDD:188098	447/1368 (33%)