DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and pgp-7

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_001361833.1	Gene:	pgp-7 / 188697	WormBaseID:	WBGene00004001	Length:	1152	Species:	Caenorhabditis elegans

Alignment Length:	1174	Identity:	268/1174 - (22%)
Similarity:	447/1174 - (38%)	Gaps:	269/1174 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 FRVTQPLFLGGLVAYYADASNQE------GDNQT----KAYLYALGVILTSACNVLFMHPYMLGM 161
            ::|....||.| .||:..||.|.      |||.|    |.|:..|     ...:..:......|.
Worm   100 YQVVLYFFLCG-CAYFTFASIQHAIMKYVGDNTTYRVRKQYISRL-----LRKDAEYFDNVSTGH 158

  Fly   162 FHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGI 226
            ....:...:.....::.:.:.|....|.|..:|..:...::               |      .:
Worm   159 LSTVLNDNLERFREVFNEKIALIFALLTDFVVGTALAFYTD---------------W------RL 202

  Fly   227 ITYLMYREIGISAFFG----VAVM---------------LLFIPLQAYL------GKKTSVLRLK 266
            .:|.::..:|| ||.|    ..||               :.|..|.||.      |:.|.:.|..
Worm   203 ASYGIFFSLGI-AFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQNTEIERYT 266

  Fly   267 TALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAI-----RNVNYIRGTLQSFI 326
            ..|:..|:.        ||....||:    .|:...|.....:|.:     .|:.| .|:|:.
Worm   267 EELKAGEKY--------GIHRALMYS----ISRGFTYFFCNSLNTVILYVGANMIY-SGSLEP-- 316

  Fly   327 MFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTF 391
                  :|.|.:..:::.|....:|....|:.....:.:|..:         ||:|:
Worm   317 ------AVVVRIFHYMMFGAFCLSEALPHISRLAGAISSTAPI---------AEMLI-------- 358

  Fly   392 MLHEETKVRDKSE-DLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQK 455
               :|..|.:|.| |.|.:                           .|...:|....:|..:..:
Worm   359 ---KEDNVIEKDETDYDVE---------------------------VEVNGNISFKNVKFSYPTR 393

  Fly   456 NTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNG-------------T 507
            .....|..||...:..:.:|::|..|||||:::|.:|...|.|||::.::|             .
Worm   394 PDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV 458

  Fly   508 LSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFEL-LPYADKTIVGERGASLSGG 571
            :...||||.||..|:.:||.||.|...........|.|...||.. .|...||||||||..||||
Worm   459 IGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGG 523

  Fly   572 QKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVI 636
            ||.||::||.:.|...|.|||:..||:|.. ...:..:.:....:....::|.|:|..:..|..|
Worm   524 QKQRIAIARTLVRNPKILLLDEATSALDNE-SEQVVQKALENASQGRTTIVVAHRLSTIRNASKI 587

  Fly   637 VIMDKGKISAMGTY-ESMAKSG----LDFAQMLTDPSKKDEGAGDAPDKKSL-SRQNSKLRDRHG 695
            ::|.||:|..:|.: |.:||.|    |..||:|       |...|..:...| :||.|:
Worm   588 IVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLL-------ESHDDHEELPPLAARQLSQ------ 639

  Fly   696 SISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGL------------FIVFAFFC 748
            .:|.:.|.|...:..:.....:..:| ||..:|.|:  ||....|            |:..|.|.
Worm   640 ELSPLHSYAIQRSTSNDAGVHDDDME-RILDELSKE--GAKKSNLREIVKQCRPDYCFLFIAVFG 701

  Fly   749 IGAQ-----VLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVS 808
            ...|     :||.                    .:.|....|  ..|..|.    :||.....:|
Worm   702 SAIQGVSYPILAQ--------------------LIVRTYEGF--AMIGEDM----LYYSHLWALS 740

  Fly   809 VIIFSLVRSML----FFYLAMRS---STTLHNTMFQGVTRAAMHFFN--TNPSGRILNRFSKDLG 864
            .:..::.|.:.    ::|....|   ||.|....|..:......|::  .:.:.|:.||.:.|..
Worm   741 FMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSS 805

  Fly   865 Q----VDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVI-VFYLLRVFY-----LST 919
            .    ||:.|..|:|.|:.|.:||. ...:.|    |.:...|.:.. :.||....|     .|.
Worm   806 NVKAAVDDRLGCVIMTVVAISIAIT-TASLYC----WKMTLEVLIFFPLLYLAEYCYDAATETSI 865

  Fly   920 SRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEF-DNYQDMHSSGYYMFLATSRAFG 983
            ..|....|...|:.|     .:|..:.|:||...:.::::.. ::.|.:|.|.:...:....|.|
Worm   866 QEDTIAFENSNRTAI-----EALENMRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANG 925

  Fly   984 YWLDCVCVVYIAVITLSFFLFSPENGGDVG-LAITQAMGMTGMVQWGMRQSAELENTMTAVE--- 1044
            ..|.|...||........:|...:....:. ..|.:.:.||..:...  .:|.|.:...||.
Worm   926 LSLSCYLFVYSVSFKFGTYLALRKEVAPMDTYLILETLSMTANMAGS--AAAYLPDYKKAVHAAG 988

  Fly  1045 ---RVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKY--FPDKAADYVLRSLNIAIEG 1104
               .:..|....|   |.|...||.    .|.|:|:.:::...|  .||:   .:|..:|:.::.
Worm   989 LIFHLFTYPATMP---FSSSDGKKN----IEKGEIIGENVQFHYDQRPDR---MILNGVNLKVDP 1043

  Fly  1105 CEKVGIVGRTGAGKSSLINALFRLSYN-EGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTM 1168
            .:.:.:||.:|.|||::|:.|.|..:. :|.:.||..:..|:.|:.|||.::::.|||.||:.::
Worm  1044 GKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSI 1108

  Fly  1169 RYNL 1172
            |.||
Worm  1109 RENL 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	268/1174 (23%)
		ABC_membrane	98..367	CDD:294371	55/299 (18%)
		ABCC_MRP_domain1	443..643	CDD:213217	69/213 (32%)
		ABC_membrane	799..1027	CDD:294371	52/248 (21%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	32/102 (31%)
pgp-7	NP_001361833.1	MdlB	42..621	CDD:224055	146/624 (23%)
		ABC_MTABC3_MDL1_MDL2	381..618	CDD:213216	77/237 (32%)
		ABC_6TM_Pgp_ABCB1_D2_like	686..994	CDD:350022	66/345 (19%)
		TM helix 1	695..718	CDD:350022	5/42 (12%)
		TM helix 2	733..781	CDD:350022	9/47 (19%)
		TM helix 3	790..835	CDD:350022	13/45 (29%)
		TM helix 4	836..885	CDD:350022	12/57 (21%)
		TM helix 5	897..947	CDD:350022	10/49 (20%)
		TM helix 6	956..989	CDD:350022	7/34 (21%)
		P-loop_NTPase	1019..>1143	CDD:393306	30/97 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000