Protein Alignment CG4562 and pgp-11

DIOPT Version :9

• Sequence 1: NP_001262747.1
• Gene: CG4562 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_001364583.1
• Gene: pgp-11 / 183971
• WormBaseID: WBGene00004005
• Length: 1241
• Species: Caenorhabditis elegans
• Alignment Length: 1395
• Identity: 301/1395 - (21%)
• Similarity: 541/1395 - (38%)
• Gaps: 322/1395 - (23%)

  Fly    65 WEKEV--------EKKRKKKKTPSLLKASMNVFGWRLAGLGLVLFILE------IGFRVTQP--L 113
            |.|::        ::.:....||| ::.|:|:. ...|....::||:.      :|..: ||  |
 Worm     3 WIKKLCRPVSAFGDESKVSDVTPS-IRQSLNLM-INFAKKSDLIFIITALICALLGGTI-QPVVL 64

  Fly   114 FLGGLVA-YYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIY 177
            .:||.:. .|....|..|:::   :||::..::.:.               :|....|.:.::|.
 Worm    65 LIGGWITDLYLTNGNTAGNDE---FLYSVLTLIYAG---------------LGFGVIILVLALIQ 111

  Fly   178 RKALRLSRTALGDTT----IGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGIS 238
            ...::...:.:.|:.    :|.|:...:|               ||.....|.||..:...|.:
 Worm   112 GVCIQRGTSRILDSIRKEFLGAVLRQDAN---------------WLDKHSSGSITCQLNENIEV- 160

  Fly   239 AFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEI-------- 295
                         :...||.|..:|           ||......|.|.......|::
 Worm   161 -------------ISDGLGNKCCML-----------VRGFAMFTSSIIACAFINWQLTFITFTMG 201

  Fly   296 PFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMF---VTRISVFVSLVG--FVLLGKLLTAEKAFV 355
            |.|..:.::.|| :|.:.|...:..:.||..:.   :..:....|..|  |::.......||
 Worm   202 PVSAFVLHLLTK-VNEVSNEELMSLSAQSHAIIEESILNVRTVQSCNGQNFMITKLNQVNEK--- 262

  Fly   356 ITAYYNILRNT-----------MTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQ 409
            |..:||  ::|           ..:||..|||.|....:..                      .|
 Worm   263 IKKFYN--KSTFWAGFFDGLALFVIYFITGISLFFGCRLYF----------------------NQ 303

  Fly   410 KLGKAG--LIAEPTVAQT---TGVLKP--------------------SSRRTSEAEHSIVISKLK 449
            ::||||  ::...|:..|   .|:|.|                    |:.::...|..|.||..:
 Worm   304 EIGKAGDVILIVNTICVTGYFLGLLGPHMSSLQQAATSFLLLYKTIESAPKSEGKEGEIKISSTR 368

  Fly   450 AKWDQKNT-------DN-TLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNG 506
            ...:.::.       || .|..:||:..|.|.||::|..|.|||:.|..:........|.:.::|
 Worm   369 GNIEFRDVRFKYFTRDNEVLQGLSLQVLPGQTVALVGTSGCGKSTSIGLLTKLYRASEGEILIDG 433

  Fly   507 -------------TLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADK 558
                         .:....|||.||.||:.:||..|..:|:...:|...........|.|....:
 Worm   434 KNIDMLDAKSLRQQIGIVQQEPKLFDGTIMENIKLGRNVDEETIKTAADIANASSFIEKLENGYE 498

  Fly   559 TIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLV 623
            |.:|..|..||||||.||.:|||:.....|.|||:..||:|:| ..|:.::.:.........:::
 Worm   499 TRLGPGGVQLSGGQKQRICIARALVTSPSILLLDEATSALDSH-NEHIVNKALTKASEGRTTIII 562

  Fly   624 THQLQFLEQADVIVIMDKGKISAMGTYESMAKSG-----LDFAQMLTDPSKKDEGAGDAPDKKSL 683
            .|:|..|:..|.|.::|:||...:||::.:...|     |..:|.:...||||.      :::.|
 Worm   563 AHRLSSLKSVDRIYVLDQGKTKEIGTHDELILLGGIYARLAKSQEVEQSSKKDW------EREEL 621

  Fly   684 SRQNSKLRDRHGSISSMESAAESLAAESPMQTQEGRVEGRI------------GMKLYKKYFGAN 736
             |:..|::.:..::..:|..:..|      |..|....|.:            |:.....|...:
 Worm   622 -RRAEKMKKKGRTVEIIEPNSTIL------QEHEHNFVGSVITENEEQKISFSGISKLFNYLPKH 679

  Fly   737 GYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVDIYY 801
            ...|.::.|.....|..|.|.| |.:|:                   ||...:.:.| |.:...|
 Worm   680 RKTLILIIALLIPRAIELCSYG-IGMSF-------------------AFKTLQRSKD-DYMTWNY 723

  Fly   802 FT-------GINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFN---TNPS---G 853
            .|       ||...::..||:  .|..:||......:...|...|....:.:|:   |:||   .
 Worm   724 ITLAQQTLAGITFWILHTSLM--YLCGWLANEVMNEVKQEMLSEVLNKPIPYFDNPETSPSACVS 786

  Fly   854 RILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFY-------- 910
            ||::........:|.                      ..|..||:|..|:|.:::.:
 Worm   787 RIISHAHNCYACLDH----------------------RAIRFVWFIAGTIFSLLLAFPFVWELGV 829

  Fly   911 -------LLRVFYL---------STSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIA 959
                   ||.:|.|         .:.:.|..........|..|:.|    :..:...|..:...:
 Worm   830 LGLGITILLTIFSLHFVSVAHRAHSEKSVMDKSGEFAVEIVEHIRA----IKLLAVEGYFENKFS 890

  Fly   960 EFDNYQDMHSS--GYYMFLATSRAFGYWLDC-VCVVYIAVITLSFFLFSPENGGDVGLAITQAMG 1021
            |:....:::.:  |:...|..:....|...| :.:.::..:.:....:||:.   |.||...|.
 Worm   891 EYLKTSEIYENKIGFVSSLNFAITQSYVFACDMLLFFVGTLLIYHGRYSPDK---VFLAFNGAQ- 951

  Fly  1022 MTGMVQWGMRQSA----ELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPE-DGKIVFDDL 1081
               |..||:...:    |:.....:..::..:.|       :::.|.......|| :||:...|:
 Worm   952 ---MSAWGVMYFSPWFPEIVRGSASANQIFSFFD-------KNRTNSTSGLSKPEINGKVEVSDV 1006

  Fly  1082 SLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDL 1145
            :..| |......|....::.|.....:.:||.:|.|||::|:.|.|. |...|.|.:|..|.:.:
 Worm  1007 TFAY-PSTPHRNVCEGFSLNIPKGHSIALVGASGCGKSTIISMLERFYSAKAGRISVDDNDIDGI 1070

  Fly  1146 GLHDLRSKISIIPQEPVLFSGTMRYNLD-PFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISE 1209
            .::.||:.||::.||||||:.|:|.|:. ..||.|..::.::.:.......:...|.|..:.:.|
 Worm  1071 DVNHLRNNISVVGQEPVLFNATIRENITIGIDEVSVEEVQKACKAANAAGFIESFPLGYDTIVGE 1135

  Fly  1210 GGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHT 1274
            ||.:.|.||:|.:.:||||:|:.:||::||||:.:|.|::.::|..:|:.....|.:.:||||.|
 Worm  1136 GGASLSGGQKQRIAIARAIIRKPKILLLDEATSALDTQSEEIVQKALRSATTGRTSIIVAHRLST 1200

  Fly  1275 VMDSDKVLVMDAGKAVEFGSPFELLTTSEK 1304
            |...|.:..:..|...|:|:..||:....|
 Worm  1201 VQHCDTIYYISRGAVAEYGTHAELVAMDSK 1230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	300/1389 (22%)
		ABC_membrane	98..367	CDD:294371	52/305 (17%)
		ABCC_MRP_domain1	443..643	CDD:213217	63/220 (29%)
		ABC_membrane	799..1027	CDD:294371	45/267 (17%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	72/222 (32%)
pgp-11	NP_001364583.1	PTZ00265	38..1235	CDD:240339	294/1358 (22%)
		MdlB	46..607	CDD:224055	138/648 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910