DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4562 and mrp-5

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:NP_510479.1 Gene:mrp-5 / 181587 WormBaseID:WBGene00003411 Length:1427 Species:Caenorhabditis elegans


Alignment Length:1416 Identity:450/1416 - (31%)
Similarity:724/1416 - (51%) Gaps:150/1416 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 REKSN---------IFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLG---SKLSAAWE 66
            |.|:|         :||.:.:.:..|..::..:..||.|.::..   ...|..|   ::|...||
 Worm    61 RNKNNGGSRIDDAGLFSFVTYSWVFPYLYQAVRGKLDRNQVWGC---SFYDSCGLNMARLEVLWE 122

  Fly    67 KEVEKKRKKKKTPSLLKASMNVFGWRL-AGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEG 130
            .|   |:...|:|||.|........|| ....:..|.|..|| :....|:..|:|:   |.|.|.
 Worm   123 DE---KKANAKSPSLFKVIYRFISTRLWFSCAVFFFCLIFGF-IGPTCFIRRLIAF---AENPER 180

  Fly   131 DNQTKAYLYALGVILTSACNVL-FMHPYMLG-----MFHIGMKARIAMTSMIYRKALRLSRTALG 189
            |.|:: .:|:.|:.|.:|.:|: |......|     .:..|::.|.|:.:::|:..|. |:...|
 Worm   181 DEQSR-IVYSYGIALVAAISVVEFARVLSYGATWAVSYRTGIRVRGAVLALLYKNVLN-SKDLCG 243

  Fly   190 DTTIGQVVNLISNDVGRLDVSVIHMNYLWLGP-VEIGIITYLMYREIGISAFFGVAVMLLFIPLQ 253
            .|. ..|:|:.:||..||..:|.....:.:|| |.:|.|.||: ..||..:..|:.|..:|..:|
 Worm   244 KTE-SDVINIFANDGQRLFDAVTFAPLVLVGPLVLVGGIGYLL-MVIGRWSLLGILVFFVFDVIQ 306

  Fly   254 AYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYI 318
            ..|||.....|....::|::|:.||.|||..|:::||..||..||..|:..|.:|...||...|.
 Worm   307 FGLGKSMVACRNLAIVKTEKRISMMAEIIKYIRIVKMNGWEQIFSAKIDQFRKEEKVQIRKSGYA 371

  Fly   319 RGTLQSFIMFVTRISVFVSLVGFVLLGKLLTAEKAF-VITAYYNILRNTMTVYFPMGISQFAELL 382
            :....:....|..::..::.||.||.|..|.|..|| .||.|:.:|.....:  |.|....||.:
 Worm   372 QSLAIACGPVVPVVAAILTFVGVVLAGNDLLASDAFSAITVYFVMLFGIRMI--PYGSRYLAEAV 434

  Fly   383 VSIRRIQTFMLHEE------TKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEH 441
            |::||||.::|.|:      |...|...|..     .|....:|..|:.     |........|:
 Worm   435 VAMRRIQEYLLLEQYAPYPVTNAEDVVLDCQ-----GATYTYQPKAAKA-----PVDETKEPTEN 489

  Fly   442 SIVISK---LKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGEL--NPDSGS 501
            .:::.:   ....:|:           |..|..:.:||||.||.|||::::|:.|.:  ..|:.|
 Worm   490 EVIVVETPVFTCSFDK-----------LSIKRGEHIAVIGAVGCGKSAILKAISGHMFTTDDALS 543

  Fly   502 VKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGA 566
            |..:.|: |..|:.|:|.|||:.|||||..|:..||...|..|.|..|...|...|:|.||||||
 Worm   544 VDRSQTV-YVPQKAWIFNGTVQDNILFGDKMNSERYYKAVNGCQLTEDLTTLSVGDRTEVGERGA 607

  Fly   567 SLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLE 631
            :||||||||::|||||::..::||.||..:::|..|...:.::.::..|:::.:::||:.::.|.
 Worm   608 TLSGGQKARVALARAVFQTKNLYLFDDIFASLDKKVANKIHEEIIQKLLKKKALMMVTNNMELLH 672

  Fly   632 QADVIVIMDKGKISAMGTYESM------AKSGLDFAQMLTDPSKKDEGAGDAPDKKS-----LSR 685
            ..|.::.::.|.|.|.|.::.:      .|:.:|..:.....|......||.|.:.:     :.|
 Worm   673 HFDRVLFVEGGNIVADGNHDILYEKNDAYKTFVDACETYQATSGATSPCGDGPAQPAPLDAEILR 737

  Fly   686 QNSKLRDRHGSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYF-GANGYGLF--IVFAFF 747
            .:|:         .::..|:.|.::     :|......|..::||:|. .|.|:.::  :|..| 
 Worm   738 NSSE---------DLKGDADKLISD-----EEDMGNSTIAWRIYKQYIHAAGGWPIWTCLVIGF- 787

  Fly   748 CIGAQVLASGGDIFLSYWVN---KNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSV 809
                 ::....:||.:||::   |.|..|..|......  |.|.:.:....||..:|.....|::
 Worm   788 -----IVNVVSNIFSTYWLSRWLKKGHDETTTITNGTE--FLEMKTSLADSPVTGFYAAVYLVAL 845

  Fly   810 IIFS---LVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILP 871
            ::.:   |.::.:|..:::.::|.||:.|||.|...|..||::.|:||||||||||:.::|..||
 Worm   846 VVLTISGLFKACVFVKVSLTAATRLHDRMFQAVIHGATSFFDSTPTGRILNRFSKDMDEIDVKLP 910

  Fly   872 SVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYS 936
            ......:|..:..:|.:||:..:..:::|..:.|.:||.:....:.:..|::||.|.::|||:|.
 Worm   911 FTAEVFLQNMITCLGFLVVITSVFPYFLLFAIPLFVVFVVFVSCFRAGIRNLKRSEHISRSPLYD 975

  Fly   937 HLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVIT-LS 1000
            |:||||.|:.||..|......:.....:.|.:|...:||.:..|....|||.:.||..|::. |:
 Worm   976 HVSASLEGITTIHTFQQSNRFLEVLKKHLDCNSGAIFMFQSAMRWLAVWLDLLVVVMTAIVALLT 1040

  Fly  1001 FFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPE-GDFESKPNK 1064
            ..|....:..|.|:||..|:.|:|:.|:.:|...|||..||:||||..|.|..|| |::.::...
 Worm  1041 VMLTGTVSPADAGMAIAFAVQMSGIFQFAVRTQTELEAKMTSVERVSYYADNIPEDGEWNTRQGL 1105

  Fly  1065 KPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRL- 1128
            .....||.:|:|.|.:::|:|  .|:....|..:...|:|.|||||:||||:|||||.|.:||| 
 Worm  1106 DIESSWPANGQINFSEVNLRY--RKSHPLALNDITFEIKGGEKVGIIGRTGSGKSSLANLIFRLY 1168

  Fly  1129 SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLK 1193
            ....|.|.||..|...:||..||..||.|.|:|.|||||:|:||||..||||:.:||:||:..||
 Worm  1169 PVTNGTIYIDGVDIRTVGLVKLRRGISAIAQDPSLFSGTVRFNLDPSLEYSDSMIWEALEKCHLK 1233

  Fly  1194 QVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRN 1258
            .:|..|...|::.:|.||.|||||:|||.|||||:|.::||:::|||||:||..||.|||..|:.
 Worm  1234 TLVQSLDKKLEADVSHGGNNFSVGERQLFCLARALLMKSRIVILDEATASVDAGTDKLIQEVIKT 1298

  Fly  1259 KFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVF---------HSMVKQT 1314
            .|.|.||:.|||||..|.:.|:::.:..||.:.|.:|.|:. ..:..|:         ||.| ..
 Worm  1299 VFADATVIIIAHRLDNVRNMDRIMHLKNGKLINFTTPQEMF-KDDWSVYKLEDKDDDQHSAV-VV 1361

  Fly  1315 GDSTFDALLKVAQKVGLRFKIQCNLSTCLSSLSSFQAHDDNLRL---KKDS 1362
            |:::..::.|                   ||..|.|..||.:::   :|||
 Worm  1362 GENSEHSMEK-------------------SSQGSSQESDDIVKVENEQKDS 1393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 435/1340 (32%)
ABC_membrane 98..367 CDD:294371 85/276 (31%)
ABCC_MRP_domain1 443..643 CDD:213217 70/204 (34%)
ABC_membrane 799..1027 CDD:294371 73/231 (32%)
ABCC_MRP_domain2 1074..1295 CDD:213211 110/221 (50%)
mrp-5NP_510479.1 MRP_assoc_pro 90..1340 CDD:188098 429/1312 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 142 1.000 Domainoid score I2904
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.830

Return to query results.
Submit another query.