DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4562 and pgp-14

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:NP_510128.1 Gene:pgp-14 / 181416 WormBaseID:WBGene00004008 Length:1327 Species:Caenorhabditis elegans


Alignment Length:1471 Identity:324/1471 - (22%)
Similarity:581/1471 - (39%) Gaps:322/1471 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 PEN--------PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSD-HLGSKLSAAW 65
            |:|        |.::|.:       .|:|..               |:.:.:|| .:.|.|.|.:
 Worm     7 PDNRGFDDQRRPSQRSTV-------LAIPAL---------------AVNDPKSDPKIASDLPANY 49

  Fly    66 EKEVEKKRKKKKTPSLLKASMNVFGWR--------------LAGLGLVLFILEIGFRVTQP---- 112
            ..: :....|..|||||:..:|....|              :.||          ||..:.    
 Worm    50 VDD-DDDAPKMYTPSLLEKILNYALCRGDIANQQLEAQPVSIPGL----------FRYGKKFDYL 103

  Fly   113 -LFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFH----------IGM 166
             ||:|.:.|..:..|..           .|.::.....|.|.::|.....|.          :|:
 Worm   104 LLFIGTICAIISGVSQP-----------ILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGI 157

  Fly   167 KARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLM 231
            ...|::|:.|.....:...|.:    :.|:.:       |...||:..|..|......|.||..:
 Worm   158 GIFISITNFIQYMCFQHCCTRV----MAQMRH-------RFVYSVLRQNAGWFDKNHSGTITTKL 211

  Fly   232 ------YREIGISAFFGVAV----MLLFIPLQAY-----------------------LGKKTSVL 263
                  .|| ||....||.:    ||:...:.||                       |.::.:..
 Worm   212 NDSMERIRE-GIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTST 275

  Fly   264 RLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFI-- 326
            .:|..:...:...:..|.:.|::.::.:..:   .:|:..... |:...|.....:|....|.  
 Worm   276 TIKELIGVGKAGSIAEESLMGVRTVQAFNGQ---EEMVGRYEA-ELEKGRKFAVWKGFWSGFFGG 336

  Fly   327 MFVTRISVFVS---LVGFVLL--GKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIR 386
            :|...:..|:.   |.|..||  |.:.|....|::     ::...:..||...||....:|:: .
 Worm   337 LFFFWLFSFLGCGMLYGAYLLKVGIITTPGDVFIV-----VMSMLLGAYFLGLISPHMMVLLN-A 395

  Fly   387 RIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAK 451
            |:....:::..   |:...:|  ...|||                  :|.......:....:..:
 Worm   396 RVSAASIYQTI---DRVPKID--PYSKAG------------------KRLQNVVGRVKFENVHFR 437

  Fly   452 WDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNG---------- 506
            :..:.....|:.::|..:|...||::|..|.|||:.:..:.....|::|:|.::|          
 Worm   438 YPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEW 502

  Fly   507 ---TLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDF-ELLPYADKTIVGERGAS 567
               |:....|||.||..|:..|:|.|.|.........|.:.|...|| |.:|....|::|:.|..
 Worm   503 LRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQ 567

  Fly   568 LSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQ 632
            ||||||.|:::||.:.|...:.|||:..||:|.. ...:....:....:....:::.|:|..:.:
 Worm   568 LSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQ-SESIVQSALNNASKGRTTIMIAHRLSTIRE 631

  Fly   633 ADVIVIMDKGKISAMGTYESMAKSG------LDFAQMLTDPSKKDEGAG---DAPDKKSLSRQNS 688
            ||.||..:||.|...|.:|.:.:.|      :...|...||...:|...   |..|....||::|
 Worm   632 ADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPEATEEFEEEEIDLDDTSRSSRRSS 696

  Fly   689 KLRDRHG------------SISSMESAAESLAAESPMQTQEGRV---EGRIGMKLYKKYFGANGY 738
            ....|.|            |.|..:.:|::.|..|.....|..:   :|:|.......:..|.|.
 Worm   697 MTSARSGSEAFRRGNSLNDSFSGSKRSAQADAENSAFAANEAAIMAEDGQITAGYLDIFKNAKGN 761

  Fly   739 GLFI----VFAFFC---IGAQVLASG----GDIFLSYWVNKNGEAERDTFMARLRRAFPETRINA 792
            .|::    |||...   :.|..|..|    |..|:.|    .|.     .|.|:..|        
 Worm   762 YLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPY----GGR-----MMHRMAMA-------- 809

  Fly   793 DTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPS---GR 854
                  :..|..:.|.|....|..|:||..::...|.......|:.:......:|: ||:   |:
 Worm   810 ------VIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFD-NPAHAPGK 867

  Fly   855 ILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWY--ILAT-VFLVIVFYLLRVFY 916
            ::.|.:.|...:..::.:.|:.|:....||:..:.: ..|..|.  ||.| :.|::.|.::.:.|
 Worm   868 LITRLASDAPNIKAVVDARMLQVIYALAAIIANIAI-AFIYCWQIGILGTSLILLLAFVMIGLAY 931

  Fly   917 -------------------LSTSRDVKRLEAVTRSPI-YSHLSASLNGLATIRAFGAQKELIAEF 961
                               :....:||.::.:||..: :.|...|    :..:.....|:.:.|.
 Worm   932 KISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTS----SKQQKRSELKKGMIEA 992

  Fly   962 DNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSFFLFSPENGGDVGLAITQAMGMTGMV 1026
            .||....|..|:|              :|..|...|.:   ::..:...|.......|| |.|.|
 Worm   993 INYSLTQSFMYFM--------------MCFTYAVGIRI---IYQGDKSSDDTFKGIIAM-MLGAV 1039

  Fly  1027 QWGMRQSA----ELENTMTAVERVVEYEDLEPE-GDFESKPNKKPPKDWPE-DGKIVFDDLSLKY 1085
              .:..||    |.....||...:......:|. ||...       .|.|| .|.|:|:::...|
 Worm  1040 --AVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLME-------GDRPEIRGNILFENVKFSY 1095

  Fly  1086 FPDKAADYVLRSLN-IAIEGCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLH 1148
             |.:....:::.|. .|:.| :.|.:||.:|:|||:.|..|.|. ....||:.||.:|...|.|.
 Worm  1096 -PQRPLQPIMKGLQWTALRG-QTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLF 1158

  Fly  1149 DLRSKISIIPQEPVLFSGTMRYNL------DPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKI 1207
            .||::::::.|||.||:||:|.|:      .|.:     |:.::||.....:.:|:||:|:.:.:
 Worm  1159 HLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLE-----KINQALELANANRFLANLPAGIDTDV 1218

  Fly  1208 SEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRL 1272
            .|.|...|.||:|.:.:|||::|:.:||::||||:.:|.:::..:|..:....:..|.:||||||
 Worm  1219 GEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRL 1283

  Fly  1273 HTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQ 1313
            .::.:||.::.:|.||..|.|:..:|:  .:|..::.::|:
 Worm  1284 SSIQNSDLIVYIDKGKVQEAGNHTQLM--HQKGRYYKLIKK 1322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 321/1454 (22%)
ABC_membrane 98..367 CDD:294371 54/323 (17%)
ABCC_MRP_domain1 443..643 CDD:213217 57/213 (27%)
ABC_membrane 799..1027 CDD:294371 48/253 (19%)
ABCC_MRP_domain2 1074..1295 CDD:213211 76/228 (33%)
pgp-14NP_510128.1 PTZ00265 104..1321 CDD:240339 299/1338 (22%)
ABC_membrane 109..377 CDD:279056 49/299 (16%)
ABC_MTABC3_MDL1_MDL2 429..666 CDD:213216 62/237 (26%)
ABC_membrane 769..1039 CDD:294371 61/316 (19%)
ABC_MTABC3_MDL1_MDL2 1086..1323 CDD:213216 78/246 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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