DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and pgp-8

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_509811.2	Gene:	pgp-8 / 181277	WormBaseID:	WBGene00004002	Length:	1243	Species:	Caenorhabditis elegans

Alignment Length:	1328	Identity:	292/1328 - (21%)
Similarity:	523/1328 - (39%)	Gaps:	303/1328 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 YLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLIS 201
            :|:.:||: ::.|..| ..|:|...|....:|.:.:|:.:       :..:|..:.:.:...:..
Worm    38 FLFVIGVV-SAICTGL-TQPFMSYTFGEVSQAFVRITAAV-------NNASLDPSDLEKAYEMFH 93

  Fly   202 NDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGV--AVMLLFIPLQAYLGKKTSVLR 264
            .|:..:   |||...:....:..|.|.:.:::.||.:..:.:  ..:|..:...|......|...
Worm    94 ADMNNV---VIHFGLVGCAFMFFGFIQFSLFKYIGDNTTYRLRHKFILRLLKKDAKYFDTISTGY 155

  Fly   265 LKTALRTD-ERVR-MMNEIISGIQVI----------------------KMYAWEIPFSKMINYVR 305
            |.|.|..: ||.| ..||.|:.|...                      .::|:.|..|.::|...
Worm   156 LSTVLNDNLERFREAFNEKIAFIICFSTDFAIGTALAFYTSWTLASYGSVFAFGIVISGLLNSTS 220

  Fly   306 TKEMNAIRNVNYIRG---TLQSFIMFVTRISV------FVSLVGFVLLGKLLTAEKAFVITA--- 358
            ..:.|..::::|...   ..|:...|.|.||:      .......:..|:...:.:||.:..
Worm   221 MMKSNEKQSMHYSNAGAIAFQALCSFKTVISLNGQTQELEKYSAELKEGEKFGSRRAFFLATSRG 285

  Fly   359 --------------------YYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLH--------- 394
                                .||...||:.:     ::.|..:|.|...:....||
Worm   286 LSHFFCNALNGTILYVGADLIYNKTMNTVAI-----VTLFHYMLFSAFSLGEAFLHISYLLNAIN 345

  Fly   395 EETKVRD---KSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKN 456
            ..|.:.|   ..:|:.|.........:..|:   .|:|.              .:.:|..:..:.
Worm   346 SATPIFDVLTSDDDMIENNQDNEQTDSNKTI---QGMLS--------------FNNVKFAYPSRP 393

  Fly   457 TDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKV-------------NGTL 508
            ..:.|..||...|..:.:|::|..|||||:::|.:|...|..||::|:             ...:
Worm   394 DVDILRGISFDVKQGECIALVGASGSGKSTIVQLLLHFYNIQSGTIKIGDSHLHDINLKQLRNAI 458

  Fly   509 SYASQEPWLFTGTVRQNILFGLP--MDKHRYRTVVKRCALERDFELLPYAD--KTIVGERGASLS 569
            ...||||.||..|:.:||.||.|  .....|..:.|..|.  || :....|  |||||||||.||
Worm   459 GVVSQEPVLFNTTIEENIRFGNPNATSSEIYEALRKANAY--DF-VCNIKDGLKTIVGERGAQLS 520

  Fly   570 GGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQAD 634
            ||||.||::||.:.:...|.|||:..||:|: .........::........:::.|:|..:...|
Worm   521 GGQKQRIAIARVLVKNPAILLLDEATSALDS-ASERAVQLALKKASEGRTTIIIAHRLSTIRHCD 584

  Fly   635 VIVIMDKGKISAMGTYESMAK-----SGLDFAQMLTDPSKKD----EGAGDAPDKKSLSRQNSK- 689
            .|::|..|||:.:|::|.:..     |.|..||.....|.::    :||.:...|...:..:.:
Worm   585 KIMVMSNGKIAEVGSHEELISMDREYSNLVRAQFFDSQSVEEDINGQGAEEVIQKTPPNLNDGEP 649

  Fly   690 ----LRDRHGSISSMESAAESLAAESP------MQTQEGRVEG-------RIGMKLYKKYF--GA 735
                |::....|....:..|.|....|      |......::|       :|.::.||.|.  |.
Worm   650 LEELLKETSSDIEIKSNIWEVLRECRPDAFLLSMAVIGSAIQGCNFPILSQIIVQTYKAYAMDGE 714

  Fly   736 N--GYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVD 798
            |  .||.|....|..:|.                             :|             |:.
Worm   715 NILTYGHFWAAMFLVLGV-----------------------------IR-------------PIT 737

  Fly   799 IYYFTGINVSVIIFSLVRSMLFFY--LAMRSSTTLHNTMFQGVTRAAMHFFNT---NPSGRILNR 858
            :|                ...||:  ::.:.||.|....||.:......|::.   :|: |::||
Worm   738 LY----------------CQFFFFGKVSEKLSTRLRIKSFQHLLSLPCAFYDDPKHSPT-RLVNR 785

  Fly   859 FSKD----LGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLST 919
            .:.|    ...||..|.|::|.::...|||    ::.|..:....|..|....|.|..:..|..|
Worm   786 LNTDPSNIKAAVDARLGSLLMSMVSFSLAI----LIACYYSWKLTLQVVLFFPVLYYAKFLYKKT 846

  Fly   920 SRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGY------------ 972
            :....:.::|............|:.:.|::|...:..:|.....|..:..:.|
Worm   847 TTISIKEDSVAFENSNKIAIEVLDNMKTVKALNMEARVINLVMEYLAVLKTSYPRRSVVMGLANG 911

  Fly   973 ------YMFLATSRAFGYWL---------DCVCVVYIAVITLSFFLFSPENGGDVGLAIT----- 1017
                  .:..|.|..||.:|         |    :|:::||||:      .....|.||:
Worm   912 FSAGCSQIVYAISFKFGTYLILQKEVIPMD----MYLSLITLSY------TSNMAGSAISYMPDF 966

  Fly  1018 -QAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDL 1081
             :|:...|::          .|..|       |....|   |.|....:.......:|:
Worm   967 RKAIHSAGLI----------FNLFT-------YPATMP---FNSDTGSRSITKGEVNGE------ 1005

  Fly  1082 SLKYFPDKAADY-VLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSY--NEGAILIDRRDTN 1143
            ::|:...:..|| ||.|:|:.:|..:.:.|||.:|:|||::| :|..:.|  ::|.|.||..:..
Worm  1006 NVKFHYHQRPDYTVLDSVNLKVEAGKTLAIVGPSGSGKSTII-SLLEMFYRADQGFIKIDNDNVE 1069

  Fly  1144 DLGLHDLRSKISIIPQEPVLFSGTMRYNL--DPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSK 1206
            ::.|..|||.:.::.|.||||:.::|.|:  ......|..::..:|:.......|..||.||.:.
Worm  1070 NINLDHLRSNLGLVSQGPVLFNCSIRDNILYGLTRNISQTEIENALQIANAFNFVFQLPQGLDTI 1134

  Fly  1207 ISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHR 1271
            :.:.|...|.||:|.:.:.|||||..::|::||||:.:|.:::.::|..:....:..:.:.:|||
Worm  1135 VGDRGAQLSGGQKQRIAITRAILRNPKLLLLDEATSALDTESEKIVQNALDTASERLSTIVVAHR 1199

  Fly  1272 LHTVMDSDKVLVMDAGKAVEFGSPFELL 1299
            |.|::::|.:.|:..||.||.|:..:||
Worm  1200 LSTIINADSIAVLRNGKVVEQGTHNQLL 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	292/1328 (22%)
		ABC_membrane	98..367	CDD:294371	49/287 (17%)
		ABCC_MRP_domain1	443..643	CDD:213217	67/216 (31%)
		ABC_membrane	799..1027	CDD:294371	52/269 (19%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	70/225 (31%)
pgp-8	NP_509811.2	PTZ00265	29..1241	CDD:240339	292/1328 (22%)
		ABC_membrane	44..326	CDD:294371	50/298 (17%)
		ABC_MTABC3_MDL1_MDL2	382..617	CDD:213216	74/238 (31%)
		ABC_membrane	685..953	CDD:279056	61/340 (18%)
		ABC_MTABC3_MDL1_MDL2	1005..1240	CDD:213216	71/230 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000