DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4562 and mrp-6

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:NP_001362008.1 Gene:mrp-6 / 180691 WormBaseID:WBGene00003412 Length:1415 Species:Caenorhabditis elegans


Alignment Length:1396 Identity:475/1396 - (34%)
Similarity:740/1396 - (53%) Gaps:128/1396 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 EKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKKKKTP 79
            :.:.:.||::|.|....:::.|....|.:.|.:..:...:.:...||.:.|...     ..|:|.
 Worm    49 DSAGLISSILFSFVGFYWWRTRNAQTDTDLLEKPSKGISAKYAAQKLESKWISS-----GPKRTH 108

  Fly    80 SLLKASMNVFGWRLAGLGL----VLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYA 140
            .|:..      |....:.:    :...||...||.|||.|..|::||.....||.. ...|...|
 Worm   109 FLVGV------WHCTKVSVMAHAISLCLEELTRVAQPLLLRELMSYYDIEEGQEFP-YWPAMQVA 166

  Fly   141 LGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVG 205
            |.:.|.|...|...|||..|:..:|..||:|...::|||:||:|.|:|.:|..||::.|::.|..
 Worm   167 LIISLLSFVTVCIHHPYFHGLLKVGNHARVATGVLLYRKSLRISLTSLFETNSGQIIQLLNTDAA 231

  Fly   206 RLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALR 270
            :|:.:.:..:|:||.|:.:....|:::...|.....|..||:..:..|.:...:..|.|.....:
 Worm   232 KLEQAFLFAHYVWLCPLLMFFYAYILWSMFGFCCLLGFLVMMAIVSFQVHYSYQLGVNRRNIGDK 296

  Fly   271 TDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVF 335
            .|.|:::|:|||:||:||||:.||..|::.|..:|..|:.|:....:....:........:|.:|
 Worm   297 MDSRLKVMSEIINGIKVIKMHGWENAFAEKIRILREDEIKAVGTSAFYSSMVMGIYFISAKIGLF 361

  Fly   336 VSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEE---- 396
            |.:.......::||....|..:|.:|.:|....::.|:|:....||..:.|||..|...||    
 Worm   362 VYIFACDYFDEILTTRGVFASSALFNSVRLPFALFLPLGLLFGRELFSTSRRIDLFFCLEEYSRI 426

  Fly   397 TKVRDKSEDLDEQKLGKAGL----IAEPTVAQTTGVLKPS-SRRTSEAEH-SIVISKLKAKW--- 452
            |...|.::..|..|..|.||    |.|          ||| :.:..:||. |:.::|:.|.|   
 Worm   427 TLELDSTDTEDGSKNEKEGLTLKKIGE----------KPSWTLKCDKAEKTSVFLNKVTAVWYDK 481

  Fly   453 ---DQKN--------TDN------------------TLDNISLKFKPRQLVAVIGPVGSGKSSLI 488
               |||.        :||                  .:.::|.:|.......:||.||||||||:
 Worm   482 DEHDQKKKKKNFKALSDNDATVIAGEKKDEPLHVVYAVQDLSFEFVAGTCYGIIGSVGSGKSSLL 546

  Fly   489 QAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELL 553
            ..:|.|.....|::.|||:.:|.:||||:|||:::.||:||...:|.||...::.|.|..|....
 Worm   547 LTILSESRMTRGNLSVNGSFAYCAQEPWIFTGSIQDNIVFGSEFNKERYENALELCLLTPDLRQF 611

  Fly   554 PYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREE 618
            ...|.||||:.|::|||||:||::||||||..||||||||||||||.|||:.|::..:||||.::
 Worm   612 ANGDMTIVGDNGSTLSGGQRARVALARAVYADADIYLLDDPLSAVDAHVGKKLYENLIRGFLSDK 676

  Fly   619 IVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLD---FAQMLTDPSKKDEGAGDA-PD 679
            :|:|||||:.||.:.|.:::|...|:...|:.:.:..:..|   ..|.:....:.||...|. |.
 Worm   677 LVILVTHQIHFLSELDSVILMKNNKMVGNGSLDELKSTFTDDFIKLQAVETEVQSDELFVDGPPS 741

  Fly   680 KKSLSRQNSKLRDRHGSISSMESAAESLAAESPMQTQ-------EGRVEGRIGMKLYKKYFGANG 737
            ....|..|.:..::....|..:.|...|:.....:|:       |.|..|.|...:|.:|  ..|
 Worm   742 SPPPSPVNIESMEKINKESIFQRANSVLSGSKMSETEYVKEIVYESRKSGTISWSVYWEY--TRG 804

  Fly   738 ------YGLFIVFAFFCIGAQVLASGGDIFLSYWVNK------NGEAERDTFMARLRRAFPETRI 790
                  ||:::|   .|:....|.:.   |:.:|:||      ...|:..|......|       
 Worm   805 VINPLKYGIWLV---VCVLITQLMNN---FVDWWLNKWLVDLDMNNADNSTSKEEFNR------- 856

  Fly   791 NAD------TDPVDIYYFTGINVSVIIFSL---VRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHF 846
            |.|      ......|..|.| :|.:|.|:   |||:.|....:.:|..|||:||..|.:....|
 Worm   857 NVDVLGYTFNVTFQTYELTFI-ISTVIMSILGVVRSVWFRNAQLMASRILHNSMFDCVLKTESEF 920

  Fly   847 FNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYL 911
            |:.|..|.||||||||:|..|::|.....:.:...|..||||.::.::....|||..|:...||.
 Worm   921 FDKNSEGMILNRFSKDIGLTDDLLAFTYFEFVFGTLTFVGIVGLVSMVRPIVILACAFITAGFYF 985

  Fly   912 LRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFL 976
            .|..|:..||::||:||..|||:.:.::::::||:||||:..:.|:|.:|....|::.:.|.|.|
 Worm   986 CRKMYVHRSRELKRIEAAARSPLNTTITSTVHGLSTIRAYRKENEMIEKFCALHDVYMAAYNMGL 1050

  Fly   977 ATSRAFGYWLDCVCVVYIAVITLSFFL-FSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTM 1040
            .::|.||..:|.:..|:::::.:...| :.....|:|||.:..|:.::|...|.|||||||||.|
 Worm  1051 LSARWFGICIDFLVSVFVSIVAIVVVLQYETLTVGEVGLCLVCAVQLSGFFSWIMRQSAELENGM 1115

  Fly  1041 TAVERVVEYEDLEPEGD----FESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIA 1101
            .:||||:||..|:.|.:    .::..:|:....||..|:|.|:::|:.|...|    ||::|:..
 Worm  1116 VSVERVLEYTKLKSEEEARRPHDAYLDKQLLNSWPTKGEIEFENVSVNYGETK----VLKNLSFV 1176

  Fly  1102 IEGCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFS 1165
            :.|.:|:|:|||||||||:||..:|.| .|..|.:.||..|.:.:.|:..|..:||||||||:||
 Worm  1177 VLGGQKIGVVGRTGAGKSTLIKIIFGLKEYCSGRVTIDGVDLDHISLNFRRGGMSIIPQEPVIFS 1241

  Fly  1166 GTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILR 1230
            ||:|.||||||||.||.:|.:||:.:||:.:.. ..||..::.:.|.:.|||||||.|||||::.
 Worm  1242 GTVRENLDPFDEYDDATIWFALEQCELKRSITK-EKGLNVELGQRGVSLSVGQRQLFCLARAMIH 1305

  Fly  1231 ENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSP 1295
            .::|||:||||||||..|||.||.|||:.||:.|::|:||||||:|:||.|:|.:.|:.|||..|
 Worm  1306 RSKILVIDEATANVDGVTDACIQKTIRDFFKNATIITVAHRLHTIMNSDNVMVFEKGELVEFDKP 1370

  Fly  1296 FELLTTSEKKVFHSMVKQTGDSTFDALLKVA 1326
            ..|| ..:..:|..|..|:|...||:|...|
 Worm  1371 ITLL-DDQSSLFSRMAAQSGAENFDSLRAAA 1400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 466/1368 (34%)
ABC_membrane 98..367 CDD:294371 81/272 (30%)
ABCC_MRP_domain1 443..643 CDD:213217 95/231 (41%)
ABC_membrane 799..1027 CDD:294371 79/231 (34%)
ABCC_MRP_domain2 1074..1295 CDD:213211 113/221 (51%)
mrp-6NP_001362008.1 MRP_assoc_pro <126..1389 CDD:188098 456/1295 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 148 1.000 Domainoid score I2739
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H74563
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 1 1.000 - - otm14754
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X771
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.830

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