Protein Alignment Mrp5 and mrp-1

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_508122.2
• Gene: mrp-1 / 180409
• WormBaseID: WBGene00003407
• Length: 1534
• Species: Caenorhabditis elegans
• Alignment Length: 1423
• Identity: 486/1423 - (34%)
• Similarity: 730/1423 - (51%)
• Gaps: 206/1423 - (14%)

  Fly     8 ELPEN--------PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAA 64
            :.|.|        |...::..:.|.|.:.....:.|.||:|::.||:...:..:::::.......
 Worm   195 DTPSNGYIGKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIEN 259

  Fly    65 WEKEVEKKRKK----------KKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLV 119
            ...|||..|:|          |..||:|......:.:.|...|....:.:: .:...|..|..|:
 Worm   260 LIPEVEGYRRKIKKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDL-LQFVAPELLRQLI 323

  Fly   120 AYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLS 184
            ::..|.:.......:.|.|..|..:|.|    :.:|.|...||.:||..|..:||.:|.|.|.||
 Worm   324 SFIEDKNQPMWIGVSIALLMFLSSLLQS----MILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLS 384

  Fly   185 RTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLF 249
            ..|....|.|.:|||:|.|:.|:......:...|..|::|.:..|.:::.:|:|...|..:::|.
 Worm   385 NEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILL 449

  Fly   250 IPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRN 314
            ||..:::..|....:::.....|||::||:||::|::|:|:|:||....||:..||.||:..::.
 Worm   450 IPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKK 514

  Fly   315 VNYIRG--TLQ-SFIMFVTRISVFVSLVGFVLL----GKLLTAEKAFVITAYYNILRNTMTVYFP 372
            ::|:..  ||. :...|:..:..|    |..:|    ..:||.:..||..|.:||||..:.| |.
 Worm   515 LSYLNAATTLSWACAPFLVAVLTF----GLYVLWDPENNVLTPQITFVALALFNILRFPLAV-FA 574

  Fly   373 MGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTS 437
            |..||..:...|..|::.|...||                                   .|.:||
 Worm   575 MVFSQAVQCSASNTRLKEFFAAEE-----------------------------------MSPQTS 604

  Fly   438 EA----EHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPD 498
            .|    :.:|.:......|..|..|..|.:|:...|..||||::|.||||||||:.|:|||:|..
 Worm   605 IAYGGTDSAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKL 669

  Fly   499 SGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGE 563
            ||||:|||:::|..|..|:...::|.||||..|.|...|:.|::.|||.:|.|.||..|:|.:||
 Worm   670 SGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGE 734

  Fly   564 RGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM---RGFLREEIVLLVTH 625
            :|.:||||||.|:|||||||:.|:|.||||||||||:|||:|:|:..:   .|.|..:..:|:||
 Worm   735 KGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTH 799

  Fly   626 QLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQ-----MLTDPSKKDEGAGDAPDKKSLSR 685
            .|.:|:..|.::::....||.||||:.:..|...|::     :|.:...|........|.|.:
 Worm   800 GLTYLKHCDQVIVLKDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEV-- 862

  Fly   686 QNSKLRD-----------------------------------------RHGSISSMESAAESLAA 709
             |..|||                                         .|.||...|.....|.|
 Worm   863 -NELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGA 926

  Fly   710 --------ESPMQTQEGRVE------GRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDI 760
                    |.|.||:...:|      |::..::|..||.|.|..:.:||....:.:.:|....::
 Worm   927 ISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNL 991

  Fly   761 FLSYW--------VNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGIN--VSVIIFSLV 815
            :|:.|        ::.||.:.             ||:|.     :.||...|:.  .||...|::
 Worm   992 YLARWSDDAKEIALSGNGSSS-------------ETQIR-----LGIYAVLGMGQATSVCAASII 1038

  Fly   816 RSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQI 880
            .::..    :.:|..||.|:.:.:.|:.|.||:..|.|||||||.||:..:|..|||.:|
 Worm  1039 MALGM----VCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDIDVIDYRLPSCIM----- 1094

  Fly   881 FLAIVGIVVVLCIINVWYILA--------TVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSH 937
              ..||.:|....|....|.|        |:.|:..::||| ||:||||.:||||:.:|||||||
 Worm  1095 --TFVGAIVQAVTIFAVPIYATPLSSFPITIVLIGYYFLLR-FYVSTSRQLKRLESASRSPIYSH 1156

  Fly   938 LSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLS-- 1000
            ...|:.|.::|||:|...:.|.|..:..|.:.:.||..:..:|    ||.....:...:|.||
 Worm  1157 FQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANR----WLAVRLEMVGNLIVLSSA 1217

  Fly  1001 ----FFLFSPE-NGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFES 1060
                :|..||. :.|.|||:::.|:.:|..:.|.:|.::|||..:.||||:.||.....||   :
 Worm  1218 GAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEG---N 1279

  Fly  1061 KPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINAL 1125
            ......||.|||:|:|...:.|::|.|  ..|.||..:...|..|||:|||||||||||||..||
 Worm  1280 NSQSLAPKSWPENGEISIKNFSVRYRP--GLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLAL 1342

  Fly  1126 FR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEE 1189
            || :..:.|.|.||..:..||.|..|||:::|:||:|||||||||.|||||..:||.::||:|..
 Worm  1343 FRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRN 1407

  Fly  1190 VKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQT 1254
            ..|...|..|..||...|||||.|.|||||||:|||||:||:.::||:|||.|.||.:||:|:|.
 Worm  1408 AHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQK 1472

  Fly  1255 TIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVK 1312
            |||.:|||||||||||||:||||||::||:|.|...||.:|.:||:..: .:|:||.|
 Worm  1473 TIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPD-GIFYSMAK 1529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	469/1334 (35%)
mrp-1	NP_508122.2	MRP_assoc_pro	23..1531	CDD:188098	486/1423 (34%)