DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4562 and mrp-1

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:NP_001024719.2 Gene:mrp-1 / 180409 WormBaseID:WBGene00003407 Length:1534 Species:Caenorhabditis elegans


Alignment Length:1415 Identity:479/1415 - (33%)
Similarity:730/1415 - (51%) Gaps:190/1415 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 ELPEN--------PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAA 64
            :.|.|        |...::..:.|.|.:.....:.|.||:|::.||:...:..:::::.......
 Worm   195 DTPSNGYIGKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIEN 259

  Fly    65 WEKEVEKKRKK----------KKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLV 119
            ...|||..|:|          |..||:|......:.:.|...|....:.:: .:...|..|..|:
 Worm   260 LIPEVEGYRRKIKKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDL-LQFVAPELLRQLI 323

  Fly   120 AYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLS 184
            ::..|.:.......:.|.|..|..:|.|    :.:|.|...||.:||..|..:||.:|.|.|.||
 Worm   324 SFIEDKNQPMWIGVSIALLMFLSSLLQS----MILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLS 384

  Fly   185 RTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLF 249
            ..|....|.|.:|||:|.|:.|:......:...|..|::|.:..|.:::.:|:|...|..:::|.
 Worm   385 NEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILL 449

  Fly   250 IPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRN 314
            ||..:::..|....:::.....|||::||:||::|::|:|:|:||....||:..||.||:..::.
 Worm   450 IPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKK 514

  Fly   315 VNYIRG--TLQ-SFIMFVTRISVFVSLVGFVLL----GKLLTAEKAFVITAYYNILRNTMTVYFP 372
            ::|:..  ||. :...|:..:..|    |..:|    ..:||.:..||..|.:||||..:.| |.
 Worm   515 LSYLNAATTLSWACAPFLVAVLTF----GLYVLWDPENNVLTPQITFVALALFNILRFPLAV-FA 574

  Fly   373 MGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTS 437
            |..||..:...|..|::.|...||                                   .|.:||
 Worm   575 MVFSQAVQCSASNTRLKEFFAAEE-----------------------------------MSPQTS 604

  Fly   438 EA----EHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPD 498
            .|    :.:|.:......|..|..|..|.:|:...|..||||::|.||||||||:.|:|||:|..
 Worm   605 IAYGGTDSAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKL 669

  Fly   499 SGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGE 563
            ||||:|||:::|..|..|:...::|.||||..|.|...|:.|::.|||.:|.|.||..|:|.:||
 Worm   670 SGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGE 734

  Fly   564 RGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM---RGFLREEIVLLVTH 625
            :|.:||||||.|:|||||||:.|:|.||||||||||:|||:|:|:..:   .|.|..:..:|:||
 Worm   735 KGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTH 799

  Fly   626 QLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQ-----MLTDPSKKDEGAGDAPDKKSLSR 685
            .|.:|:..|.::::....||.||||:.:..|...|::     :|.:...|........|.|.:  
 Worm   800 GLTYLKHCDQVIVLKDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEV-- 862

  Fly   686 QNSKLRD-----------------------------------------RHGSISSMESAAESLAA 709
             |..|||                                         .|.||...|.....|.|
 Worm   863 -NELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGA 926

  Fly   710 --------ESPMQTQEGRVE------GRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDI 760
                    |.|.||:...:|      |::..::|..||.|.|..:.:||....:.:.:|....::
 Worm   927 ISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNL 991

  Fly   761 FLSYW--------VNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGIN--VSVIIFSLV 815
            :|:.|        ::.||.:.             ||:|.     :.||...|:.  .||...|::
 Worm   992 YLARWSDDAKEIALSGNGSSS-------------ETQIR-----LGIYAVLGMGQATSVCAASII 1038

  Fly   816 RSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQI 880
            .::..    :.:|..||.|:.:.:.|:.|.||:..|.|||||||.||:..||..:|..|...::.
 Worm  1039 MALGM----VCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDVDGVDTDIPRTMSMFIRT 1099

  Fly   881 FLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGL 945
            .::.:.|:.::.......|...:.|.||::::..||:||||.:||||:.:|||||||...|:.|.
 Worm  1100 AVSSIEIIAIILWATPLAISLLLPLFIVYFVVLRFYVSTSRQLKRLESASRSPIYSHFQESIQGA 1164

  Fly   946 ATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLS------FFLF 1004
            ::|||:|...:.|.|..:..|.:.:.||..:..:|    ||.....:...:|.||      :|..
 Worm  1165 SSIRAYGVVDKFIRESQHRVDENLATYYPSIVANR----WLAVRLEMVGNLIVLSSAGAAVYFRD 1225

  Fly  1005 SPE-NGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPK 1068
            ||. :.|.|||:::.|:.:|..:.|.:|.::|||..:.||||:.||.....||   :......||
 Worm  1226 SPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEG---NNSQSLAPK 1287

  Fly  1069 DWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFR-LSYNE 1132
            .|||:|:|...:.|::|.|  ..|.||..:...|..|||:|||||||||||||..|||| :..:.
 Worm  1288 SWPENGEISIKNFSVRYRP--GLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADG 1350

  Fly  1133 GAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVA 1197
            |.|.||..:..||.|..|||:::|:||:|||||||||.|||||..:||.::||:|....|...|.
 Worm  1351 GCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVK 1415

  Fly  1198 DLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKD 1262
            .|..||...|||||.|.|||||||:|||||:||:.::||:|||.|.||.:||:|:|.|||.:|||
 Worm  1416 SLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKD 1480

  Fly  1263 CTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVK 1312
            ||||||||||:||||||::||:|.|...||.:|.:||:..: .:|:||.|
 Worm  1481 CTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPD-GIFYSMAK 1529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 473/1397 (34%)
ABC_membrane 98..367 CDD:294371 78/275 (28%)
ABCC_MRP_domain1 443..643 CDD:213217 95/202 (47%)
ABC_membrane 799..1027 CDD:294371 76/236 (32%)
ABCC_MRP_domain2 1074..1295 CDD:213211 126/221 (57%)
mrp-1NP_001024719.2 MRP_assoc_pro 23..1531 CDD:188098 479/1415 (34%)
ABC_membrane 309..570 CDD:294371 78/269 (29%)
ABCC_MRP_domain1 614..815 CDD:213217 95/200 (48%)
ABC_membrane 976..1248 CDD:279056 84/297 (28%)
ABCC_MRP_domain2 1293..1513 CDD:213211 126/221 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.830

Return to query results.
Submit another query.