Protein Alignment Mrp5 and mrp-2

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_508121.1
• Gene: mrp-2 / 180408
• WormBaseID: WBGene00003408
• Length: 1525
• Species: Caenorhabditis elegans
• Alignment Length: 1386
• Identity: 468/1386 - (33%)
• Similarity: 733/1386 - (52%)
• Gaps: 159/1386 - (11%)

  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKK-- 75
            |...::..:.|.|.:.....:.|.||:|:..||:...:..::::|........:..:::..:.
 Worm   208 PEYTASFINRLTFQWFTGLAYLGNKKSLENEDLWDLNEIDKAENLIPSFMQNLKPRIDEYHQNIK 272

  Fly    76 --------KKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQ---PLFLGGLVAYYADASNQE 129
                    |..||.:......:.:.|    |..|..::.|.:.|   |..|..|:.:..| .||.
 Worm   273 KDPSAALPKNHPSFVIPIFKTYKYTL----LAGFFYKLCFDMLQFLAPQLLKQLIGFIED-KNQP 332

  Fly   130 ---GDNQTKAYLYALGVI-LTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGD 190
               |.:       .:|:: .:|....:|:|.|...||.:||..|..:||.:|.|||.||..|...
 Worm   333 VWIGCS-------IVGIMFFSSFLQSMFLHQYYHSMFRLGMHVRSVLTSAVYSKALNLSNEARKG 390

  Fly   191 TTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAY 255
            .|||.:|||:|.|:.::......:...|..|::|.:..|.:::.:|::|..|:.|::|.:|:...
 Worm   391 KTIGAIVNLMSVDIQKIQDMAPTIMLFWSAPLQIFLSIYFLWKFLGVAALAGLVVLILALPVNGL 455

  Fly   256 LG-----KKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNV 315
            :.     .:|..::||     |||::||:||::|::|:|:|:||.....|:..:|.:|::.::.:
 Worm   456 IAIQMRKCQTEQMKLK-----DERIKMMSEILNGMKVLKLYSWERSMENMVLKIRERELHILKKL 515

  Fly   316 NYIRGTLQSFIMFVTRISVFVSLVGFVLL---GKLLTAEKAFVITAYYNILRNTMTVYFPMGISQ 377
            :|....:....:....::..:|.|.:|.|   ..:||.|..||..:.::|||..:.: ..|...:
 Worm   516 SYFMAAIVFSWICAPFLASVISFVVYVYLDPENNVLTPEITFVALSLFDILRMPLAM-VAMVYGE 579

  Fly   378 FAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHS 442
            ..:..||..|::.|...||                     ..|..:.:.|          |.:.:
 Worm   580 AVQCSVSNTRLKEFFAAEE---------------------MSPQTSISHG----------ETDSA 613

  Fly   443 IVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGT 507
            |.:......| ..:.|.||..||.|.:..||||::|.||||||||:.|:|||:|..||||::||.
 Worm   614 IEVENGLFSW-SSDEDPTLREISFKIQKGQLVAIVGKVGSGKSSLLHALLGEMNKLSGSVQINGN 677

  Fly   508 LSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQ 572
            ::|..|:.|:...::|.||||..|.|...|..|||.|||:.|...||..|:|.:||:|.:|||||
 Worm   678 IAYVPQQAWIQNMSLRNNILFNKPYDLENYEDVVKNCALKEDLANLPAGDRTEIGEKGINLSGGQ 742

  Fly   573 KARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM---RGFLREEIVLLVTHQLQFLEQAD 634
            |.|:|||||||:..||.||||||||||:|||:|:|:..:   .|.|..:..:||||.|.:|:..|
 Worm   743 KQRVSLARAVYQNPDIILLDDPLSAVDSHVGKHIFENVISSSTGCLASKTRVLVTHGLTYLKHCD 807

  Fly   635 VIVIMDKGKISAMGTYESMAKSGLDFA----QMLTDPSKK-------DEGAGDAPD--------- 679
            .::::.:|.||.:|||:.:..:...||    :.|.:.||.       .:|:|:..:
 Worm   808 QLIVLKEGTISELGTYQELLNNSGAFAEFLEEFLIEESKTRGRVASIGDGSGEVDEILRDLGQVK 872

  Fly   680 -------KKSLSRQNSKLRDRHGSIS-SMESAAESLAAESPMQTQE------GRVE--------- 721
                   :..||:::.|......:|. |.:|:..|:...||....|      |.:.
 Worm   873 PGILKRLESHLSQESDKEDTSARAIEYSRDSSRRSVLLHSPRSQHEENEALLGAISEDVPAQENT 937

  Fly   722 ----------GRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDT 776
                      |::..::|..||.|....:.::|.|..:|    :||..|..::::.|..:
 Worm   938 QLIEKETVETGKVKFEVYIAYFQAISIPITLLFFFLYVG----SSGLGILSNFYLAKLSD----- 993

  Fly   777 FMARLRRAFPETRINADTD-PVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVT 840
                  .|....|.::|.. .:.||...|:..|.::  |:.|::.....:|:|..||..:...:.
 Worm   994 ------HAKSGNRTSSDAKMELGIYAVLGMGQSFVV--LIASIILTIGVLRASRILHAGLLGNIM 1050

  Fly   841 RAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFL 905
            |:.|.||:..|.||||||..||:..:|..||.|:..:......:|..:||:.....|..:|...|
 Worm  1051 RSPMAFFDVTPIGRILNRIGKDIEAIDRTLPDVIRHMSMTIFNVVATLVVIMWATPWAGIAFAIL 1115

  Fly   906 VIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSS 970
            .::::::..||:||||.:||||:.:|||||||...|:.|.::|||||.....|.:.....|.|..
 Worm  1116 SVIYFIVLRFYISTSRQLKRLESASRSPIYSHFQESIQGASSIRAFGVVDNFIKQSQQRVDDHLI 1180

  Fly   971 GYYMFLATSRAFGYWLDCV--CVVYIAVITLSFFLFSPE-NGGDVGLAITQAMGMTGMVQWGMRQ 1032
            .||..:..:|.....|:.|  .:|..|.....:|..||. :.|.|||:::.|:.:|..:.|.:|.
 Worm  1181 AYYPSIVANRWLAVRLEMVGNLIVLSAAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRM 1245

  Fly  1033 SAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRS 1097
            ::|||..:.:|||:.||.....||   :...:...|.|||.|:|...:.|::|.|  ..|.||..
 Worm  1246 TSELETNIVSVERIKEYTVTPTEG---NNSRRLAAKSWPEKGEISIKNFSVRYRP--GLDLVLHG 1305

  Fly  1098 LNIAIEGCEKVGIVGRTGAGKSSLINALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEP 1161
            ::..|...||||||||||||||||..|||| :..:.|:|.||..:..:|.|..|||.::|:||:|
 Worm  1306 ISAHIAPSEKVGIVGRTGAGKSSLTLALFRIIEADGGSIEIDGINIANLQLEQLRSCLTIVPQDP 1370

  Fly  1162 VLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLAR 1226
            |||||||:.|||||..|||:::||:||...||..|..|..||:.||||||.|.|||||||:||||
 Worm  1371 VLFSGTMKMNLDPFSAYSDSQVWEALENAHLKPFVKSLQDGLEHKISEGGENLSVGQRQLICLAR 1435

  Fly  1227 AILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVE 1291
            |:||:.::||:|||.|.||.:||:|||.|||.:||:||||||||||:||||||::||:|.|:..|
 Worm  1436 ALLRKTKVLVLDEAAAAVDVETDSLIQKTIREQFKECTVLTIAHRLNTVMDSDRLLVLDKGRVAE 1500

  Fly  1292 FGSPFELLTTSEKKVFHSMVK 1312
            |.||..||...: .:|:||.|
 Worm  1501 FDSPKNLLANPD-GIFYSMAK 1520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	457/1310 (35%)
mrp-2	NP_508121.1	MRP_assoc_pro	25..1522	CDD:188098	468/1386 (34%)