DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and mrp-2

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_508121.1	Gene:	mrp-2 / 180408	WormBaseID:	WBGene00003408	Length:	1525	Species:	Caenorhabditis elegans

Alignment Length:	1386	Identity:	468/1386 - (33%)
Similarity:	733/1386 - (52%)	Gaps:	159/1386 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKK-- 75
            |...::..:.|.|.:.....:.|.||:|:..||:...:..::::|........:..:::..:.
Worm   208 PEYTASFINRLTFQWFTGLAYLGNKKSLENEDLWDLNEIDKAENLIPSFMQNLKPRIDEYHQNIK 272

  Fly    76 --------KKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQ---PLFLGGLVAYYADASNQE 129
                    |..||.:......:.:.|    |..|..::.|.:.|   |..|..|:.:..| .||.
Worm   273 KDPSAALPKNHPSFVIPIFKTYKYTL----LAGFFYKLCFDMLQFLAPQLLKQLIGFIED-KNQP 332

  Fly   130 ---GDNQTKAYLYALGVI-LTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGD 190
               |.:       .:|:: .:|....:|:|.|...||.:||..|..:||.:|.|||.||..|...
Worm   333 VWIGCS-------IVGIMFFSSFLQSMFLHQYYHSMFRLGMHVRSVLTSAVYSKALNLSNEARKG 390

  Fly   191 TTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAY 255
            .|||.:|||:|.|:.::......:...|..|::|.:..|.:::.:|::|..|:.|::|.:|:...
Worm   391 KTIGAIVNLMSVDIQKIQDMAPTIMLFWSAPLQIFLSIYFLWKFLGVAALAGLVVLILALPVNGL 455

  Fly   256 LG-----KKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNV 315
            :.     .:|..::||     |||::||:||::|::|:|:|:||.....|:..:|.:|::.::.:
Worm   456 IAIQMRKCQTEQMKLK-----DERIKMMSEILNGMKVLKLYSWERSMENMVLKIRERELHILKKL 515

  Fly   316 NYIRGTLQSFIMFVTRISVFVSLVGFVLL---GKLLTAEKAFVITAYYNILRNTMTVYFPMGISQ 377
            :|....:....:....::..:|.|.:|.|   ..:||.|..||..:.::|||..:.: ..|...:
Worm   516 SYFMAAIVFSWICAPFLASVISFVVYVYLDPENNVLTPEITFVALSLFDILRMPLAM-VAMVYGE 579

  Fly   378 FAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHS 442
            ..:..||..|::.|...||                     ..|..:.:.|          |.:.:
Worm   580 AVQCSVSNTRLKEFFAAEE---------------------MSPQTSISHG----------ETDSA 613

  Fly   443 IVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGT 507
            |.:......| ..:.|.||..||.|.:..||||::|.||||||||:.|:|||:|..||||::||.
Worm   614 IEVENGLFSW-SSDEDPTLREISFKIQKGQLVAIVGKVGSGKSSLLHALLGEMNKLSGSVQINGN 677

  Fly   508 LSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQ 572
            ::|..|:.|:...::|.||||..|.|...|..|||.|||:.|...||..|:|.:||:|.:|||||
Worm   678 IAYVPQQAWIQNMSLRNNILFNKPYDLENYEDVVKNCALKEDLANLPAGDRTEIGEKGINLSGGQ 742

  Fly   573 KARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM---RGFLREEIVLLVTHQLQFLEQAD 634
            |.|:|||||||:..||.||||||||||:|||:|:|:..:   .|.|..:..:||||.|.:|:..|
Worm   743 KQRVSLARAVYQNPDIILLDDPLSAVDSHVGKHIFENVISSSTGCLASKTRVLVTHGLTYLKHCD 807

  Fly   635 VIVIMDKGKISAMGTYESMAKSGLDFA----QMLTDPSKK-------DEGAGDAPD--------- 679
            .::::.:|.||.:|||:.:..:...||    :.|.:.||.       .:|:|:..:
Worm   808 QLIVLKEGTISELGTYQELLNNSGAFAEFLEEFLIEESKTRGRVASIGDGSGEVDEILRDLGQVK 872

  Fly   680 -------KKSLSRQNSKLRDRHGSIS-SMESAAESLAAESPMQTQE------GRVE--------- 721
                   :..||:::.|......:|. |.:|:..|:...||....|      |.:.
Worm   873 PGILKRLESHLSQESDKEDTSARAIEYSRDSSRRSVLLHSPRSQHEENEALLGAISEDVPAQENT 937

  Fly   722 ----------GRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDT 776
                      |::..::|..||.|....:.::|.|..:|    :||..|..::::.|..:
Worm   938 QLIEKETVETGKVKFEVYIAYFQAISIPITLLFFFLYVG----SSGLGILSNFYLAKLSD----- 993

  Fly   777 FMARLRRAFPETRINADTD-PVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVT 840
                  .|....|.::|.. .:.||...|:..|.::  |:.|::.....:|:|..||..:...:.
Worm   994 ------HAKSGNRTSSDAKMELGIYAVLGMGQSFVV--LIASIILTIGVLRASRILHAGLLGNIM 1050

  Fly   841 RAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFL 905
            |:.|.||:..|.||||||..||:..:|..||.|:..:......:|..:||:.....|..:|...|
Worm  1051 RSPMAFFDVTPIGRILNRIGKDIEAIDRTLPDVIRHMSMTIFNVVATLVVIMWATPWAGIAFAIL 1115

  Fly   906 VIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSS 970
            .::::::..||:||||.:||||:.:|||||||...|:.|.::|||||.....|.:.....|.|..
Worm  1116 SVIYFIVLRFYISTSRQLKRLESASRSPIYSHFQESIQGASSIRAFGVVDNFIKQSQQRVDDHLI 1180

  Fly   971 GYYMFLATSRAFGYWLDCV--CVVYIAVITLSFFLFSPE-NGGDVGLAITQAMGMTGMVQWGMRQ 1032
            .||..:..:|.....|:.|  .:|..|.....:|..||. :.|.|||:::.|:.:|..:.|.:|.
Worm  1181 AYYPSIVANRWLAVRLEMVGNLIVLSAAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRM 1245

  Fly  1033 SAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRS 1097
            ::|||..:.:|||:.||.....||   :...:...|.|||.|:|...:.|::|.|  ..|.||..
Worm  1246 TSELETNIVSVERIKEYTVTPTEG---NNSRRLAAKSWPEKGEISIKNFSVRYRP--GLDLVLHG 1305

  Fly  1098 LNIAIEGCEKVGIVGRTGAGKSSLINALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEP 1161
            ::..|...||||||||||||||||..|||| :..:.|:|.||..:..:|.|..|||.::|:||:|
Worm  1306 ISAHIAPSEKVGIVGRTGAGKSSLTLALFRIIEADGGSIEIDGINIANLQLEQLRSCLTIVPQDP 1370

  Fly  1162 VLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLAR 1226
            |||||||:.|||||..|||:::||:||...||..|..|..||:.||||||.|.|||||||:||||
Worm  1371 VLFSGTMKMNLDPFSAYSDSQVWEALENAHLKPFVKSLQDGLEHKISEGGENLSVGQRQLICLAR 1435

  Fly  1227 AILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVE 1291
            |:||:.::||:|||.|.||.:||:|||.|||.:||:||||||||||:||||||::||:|.|:..|
Worm  1436 ALLRKTKVLVLDEAAAAVDVETDSLIQKTIREQFKECTVLTIAHRLNTVMDSDRLLVLDKGRVAE 1500

  Fly  1292 FGSPFELLTTSEKKVFHSMVK 1312
            |.||..||...: .:|:||.|
Worm  1501 FDSPKNLLANPD-GIFYSMAK 1520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	463/1372 (34%)
		ABC_membrane	98..367	CDD:294371	80/283 (28%)
		ABCC_MRP_domain1	443..643	CDD:213217	97/202 (48%)
		ABC_membrane	799..1027	CDD:294371	76/230 (33%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	128/221 (58%)
mrp-2	NP_508121.1	MRP_assoc_pro	25..1522	CDD:188098	468/1386 (34%)
		ABC_membrane	309..570	CDD:294371	77/273 (28%)
		ABCC_MRP_domain1	614..816	CDD:213217	97/202 (48%)
		ABC_membrane	971..1239	CDD:279056	85/284 (30%)
		ABCC_MRP_domain2	1284..1504	CDD:213211	128/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730