DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and mrp-7

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_507812.3	Gene:	mrp-7 / 180289	WormBaseID:	WBGene00003413	Length:	1525	Species:	Caenorhabditis elegans

Alignment Length:	1387	Identity:	483/1387 - (34%)
Similarity:	749/1387 - (54%)	Gaps:	155/1387 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKK- 75
            :|..:|:..:.|...:.....:.|.::.|:.:|::. |.|......   ||..||...|.||.|
Worm   207 SPELQSSFLNRLTLWWFNSIPWTGARRDLEIDDIFE-LNERSGTEF---LSELWESFWEPKRLKY 267

  Fly    76 --------KK-----------TPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAY 121
                    ||           .||::.:...:|.|.......:.|:.:. .:...|..|..|:.:
Worm   268 IHDTSIWAKKDPSEQEKDPVVIPSVVSSLFMMFRWEFLLASTLKFVSDT-MQFASPFLLHELLNF 331

  Fly   122 YA--DASNQEGDNQTKAYLYALGVILTSACNV--LFMHPYMLGMFHIGMKARIAMTSMIYRKALR 182
            .:  :|...:|        .||.:::.|...:  |.::.|...||.:|.|.:.::|:.:|:|.|.
Worm   332 ISAKNAPFWKG--------MALSILMFSVSELRSLILNGYFYIMFRMGTKIQTSLTAAVYKKTLL 388

  Fly   183 LSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVML 247
            :|.:|..|.|:|::|||::.||.|..:....:...|..|.:|......::..:|.||..||.:|:
Worm   389 ISNSARRDRTVGEIVNLMAIDVERFQMITPQIQQFWSCPYQITFALVYLFITLGYSALPGVVIMV 453

  Fly   248 LFIP---LQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEM 309
            :|:|   :.:.:.:|..:.::|.   .|||.:|:||:::||:|:|:||||:|....|:.:||||:
Worm   454 IFVPMNIISSMIVRKWQIEQMKL---KDERTKMVNEVLNGIKVVKLYAWEVPMEAYIDEIRTKEL 515

  Fly   310 NAIRNVNYIRGTLQSFIMFVTRISVFVSLVGFVLL--GKLLTAEKAFVITAYYNILRNTMTVYFP 372
            ..|:....:|..|.||......:....|...|||.  ..|||.:.|||..|.:|.||:.||: ..
Worm   516 ALIKKSAMVRNILDSFNTASPFLVALFSFGTFVLSNPSHLLTPQIAFVSLALFNQLRSPMTM-IA 579

  Fly   373 MGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTS 437
            :.|:|..:.:||.:|::.|::         :|:|||:.:.::..|
Worm   580 LLINQAVQAVVSNKRLKEFLV---------AEELDEKCVDRSVNI-------------------- 615

  Fly   438 EAEHSIV-ISKLKAKWDQKNT--DNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDS 499
            |..|:.| :..|.|.||.:..  :.||.::.|......|:||:|.||||||||:||:|||:....
Worm   616 ERSHNAVRVENLTASWDPEEAAGEKTLQDVDLTAPRNSLIAVVGKVGSGKSSLLQALLGEMGKLR 680

  Fly   500 GSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGER 564
            |.:.|||.::|..|:||:...|:|.||.||.|.|:.||..|:..|||:.|.::||..|:|.:||:
Worm   681 GRIGVNGRVAYVPQQPWIQNMTLRDNITFGRPFDRKRYDQVLYACALKADIKILPAGDQTEIGEK 745

  Fly   565 GASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM--RGFLREEIVLLVTHQL 627
            |.:||||||||:|||||||:..|:|||||||||||.|||||:|::.:  .|.|||:..:||||.|
Worm   746 GINLSGGQKARVSLARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVIGPNGLLREKTRILVTHGL 810

  Fly   628 QFLEQADVIVIMDKGKISAMGTYESMAK-SGL--DFAQMLTDPSKKDEGAGDA------------ 677
            .:.:.||.|::|.:|||...||:|.:.| .||  ||.:.....|.....||.:
Worm   811 TYTKMADEILVMLEGKIEESGTFEHLIKRRGLFFDFMEEYKSGSDNSSEAGGSQDDDFEAIGGEI 875

  Fly   678 -----PDKKSLSRQNS--------KLRDRHGSISSME------SAAESLAAESPMQTQEGRVEGR 723
                 |:...|:..|.        :|..:..::||.|      |.|.:..:::.:..:||..:|:
Worm   876 QDYMNPEDVVLTVTNDLDETIRTPELTTQISTMSSPEKPPTGTSPAAATESQNKLIKKEGIAQGK 940

  Fly   724 IGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNK-NGEAERDTFMARLRRAFPE 787
            :.:..|:.|..|.||.|.|.|..|.|....|    .|..|:|::. :.|.:.|:         |.
Worm   941 VEIATYQLYVKAAGYLLSIAFIGFFIVYMTL----QILRSFWLSAWSDEYDPDS---------PS 992

  Fly   788 TRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPS 852
            ....|....:.:|...|.:.:...|..:.:::|  :..|:|..||..:...:.|:.|.|::|.|.
Worm   993 AHPMAKGWRLGVYGALGFSETACFFVALLALVF--VGQRASKNLHGPLIHNLMRSPMSFYDTTPL 1055

  Fly   853 GRILNRFSKDLGQVDEILPS----VMMDVMQIFLAIVGIVVVLCIINVWYI-LATVFLVIVFYLL 912
            ||||||.:||:..:|.:||.    ::|.|:|:...::.|::...:..|..: ||.::|:.:.|
Worm  1056 GRILNRCAKDIETIDMMLPMNFRYLVMCVLQVAFTLIVIIISTPLFAVVILPLALIYLIFLRY-- 1118

  Fly   913 RVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLA 977
               |:.|||.:||||:|.|||||||...::.|.|:|||||...|...:.....|......|..|.
Worm  1119 ---YVPTSRQLKRLESVHRSPIYSHFGETIQGAASIRAFGKVDEFRQDSGRILDTFIRCRYSSLV 1180

  Fly   978 TSRAFGYWLDCV--CVVYIAVITLSFFLFSPENG-----GDVGLAITQAMGMTGMVQWGMRQSAE 1035
            ::|.....|:.|  |:::.|.:   |.:.|.|.|     |.:|::::.|:.:|.::.:.:||.:|
Worm  1181 SNRWLAVRLEFVGNCIIFFAAL---FAVLSKEFGWITSPGVIGVSVSYALNITEVLNFAVRQVSE 1242

  Fly  1036 LENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNI 1100
            :|..:.:||||.||.:...|..:..: .::|...||..|.:.||..|.:|  .:..|.||..::.
Worm  1243 IEANIVSVERVNEYTNTPNEAPWRIE-GREPAPGWPSRGVVKFDGYSTRY--REGLDLVLHDISA 1304

  Fly  1101 AIEGCEKVGIVGRTGAGKSSLINALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLF 1164
            .:...||:||||||||||||...|||| :....|.|:||..:.:.:|||||||.|:||||:||||
Worm  1305 DVAAGEKIGIVGRTGAGKSSFALALFRMIEAAGGRIVIDDVEVSQIGLHDLRSNITIIPQDPVLF 1369

  Fly  1165 SGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAIL 1229
            |||:|:|||||..|||.::|.:||...||...|.||.||..||||.|.|.||||||||.||||:|
Worm  1370 SGTLRFNLDPFFTYSDDQIWRALELAHLKHFAAGLPDGLLYKISEAGENLSVGQRQLVALARALL 1434

  Fly  1230 RENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGS 1294
            |..|:||:|||||.||..||||||.|||.:||:|||.||||||:|:||.|:::|:|.|..:||.:
Worm  1435 RHTRVLVLDEATAAVDVATDALIQETIREEFKECTVFTIAHRLNTIMDYDRIMVLDKGSILEFDT 1499

  Fly  1295 PFELLTTSEKKVFHSMVKQTGD 1316
            | :.|...:...|..||....:
Worm  1500 P-DALMADKNSAFAKMVADAAE 1520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	479/1369 (35%)
		ABC_membrane	98..367	CDD:294371	82/277 (30%)
		ABCC_MRP_domain1	443..643	CDD:213217	101/204 (50%)
		ABC_membrane	799..1027	CDD:294371	73/239 (31%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	127/221 (57%)
mrp-7	NP_507812.3	MRP_assoc_pro	14..1518	CDD:188098	483/1383 (35%)
		ABC_membrane	310..575	CDD:294371	82/276 (30%)
		ABCC_MRP_domain1	622..826	CDD:213217	101/203 (50%)
		ABC_membrane	976..1227	CDD:279056	77/269 (29%)
		ABCC_MRP_domain2	1280..1500	CDD:213211	127/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730