DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and pmp-5

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_504689.1	Gene:	pmp-5 / 179056	WormBaseID:	WBGene00004062	Length:	598	Species:	Caenorhabditis elegans

Alignment Length:	668	Identity:	134/668 - (20%)
Similarity:	246/668 - (36%)	Gaps:	142/668 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   713 MQTQEGRVEGRIGMKLYKKYFGANGYGLFIVF---------AFFCIGAQVLASGGDIFLSYWVNK 768
            :|..|.:.|  .|.:::        |.||.:|         ........:.||.|:..::|   |
Worm     4 LQVIEKKFE--FGFRVF--------YNLFRLFPLIYSNTWLTLVLTAVTIAASVGNEIVNY---K 55

  Fly   769 NGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFF----YLAMRSST 829
            .|......::|.:.:..|:.        ..|::...: ..|.:..|:..|.||    |:..|.:.
Worm    56 TGVIPGKFYVALIEKDEPKF--------WHIFWIASL-CYVGLCLLMALMNFFSWCLYIQQRKNL 111

  Fly   830 T--LH-----NTMFQGVTRAAMHFFNTNPSGRI---LNRFSKDLGQVDEILPSVMMDVMQIFLAI 884
            .  ||     |..:..:.....|..: ||..||   .::.:|.||  ..|:|:|::.  ...::.
Worm   112 VQCLHKLYYKNNFYYQLNGVDDHGID-NPDQRITQDADKLTKLLG--TSIIPTVLLS--PFIISY 171

  Fly   885 VGIVVVLCIINVW-------YILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASL 942
            .|       :.||       :.:...:.:|...:.|:.....:....|:|.......|.|:|..:
Worm   172 YG-------VRVWETAGGWGFGMIVAYFLIGVIINRILIGPITPWAARVEKAEGDFRYKHVSVRV 229

  Fly   943 NGLATIRAFGAQKELIAEFDN-YQDMHSSGYYMFLAT-------SRAFGYWLDCV--CVVYIAVI 997
            |  |...||...    |||:: :.|:.....:..|..       |:.|..:.|..  |:.||..:
Worm   230 N--AEESAFYKS----AEFEHVFSDLSFDVLFKRLLNFMCWRFPSQFFQSFFDYYGGCMSYILQL 288

  Fly   998 TLSFFLFSPENGGDVGLAITQAMG---------------MTGMVQWGMRQSAELENTMTAVERVV 1047
            ...|.....:|     |...:..|               .|.:....| ..|||...:..|...|
Worm   289 FPLFVFHMYDN-----LTPAELSGQISNNAFYFIYLINCFTRLTDLAM-NIAELGGYIMRVSEFV 347

  Fly  1048 EYEDLEPEG---DFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVG 1109
            :...|...|   :...:.::.|.|...:|..|..:.||... |..:...::.:|...:...:.:.
Worm   348 DTGKLHQSGIKNEAFRRNSELPEKASGDDNLIETEHLSFGP-PTNSNIRIIENLTFHLPRNKTLL 411

  Fly  1110 IVGRTGAGKSSLINALFRLSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYN--- 1171
            |.|.:|.||:||:..:..:..::|.          |..|..::....:||:|....|.:...
Worm   412 ITGDSGIGKTSLMRVIADMWPHQGI----------LKKHFKKTDAYFLPQKPYFPVGRLSLKQQL 466

  Fly  1172 LDPFDEY-----SDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRE 1231
            :.|.:|.     :|.::...|.|:||..::..:.:...|...|.....|.|::|.:|.||.||.|
Worm   467 VFPAEENEEKSGNDEEIVRILHELKLGHLLPIVGNIHDSVDFEWQETLSPGEQQRLCFARMILAE 531

  Fly  1232 NRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPF 1296
            ..:..:||:|.|||...:..:...:|.  ...|.:::.||                |::.....|
Worm   532 PTVAFLDESTCNVDEGMENAMYEMLRK--HSITYISVGHR----------------KSLRSHHDF 578

  Fly  1297 EL-LTTSEKKVFHSMVKQ 1313
            || :.:|...:||.:..|
Worm   579 ELRIPSSSSFLFHEIHNQ 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	130/653 (20%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217
		ABC_membrane	799..1027	CDD:294371	52/273 (19%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	48/228 (21%)
pmp-5	NP_504689.1	YddA	33..582	CDD:226646	122/613 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910