DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4562 and cft-1

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:NP_504463.1 Gene:cft-1 / 178939 WormBaseID:WBGene00000477 Length:1247 Species:Caenorhabditis elegans


Alignment Length:1355 Identity:324/1355 - (23%)
Similarity:604/1355 - (44%) Gaps:207/1355 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKK 75
            ||.:.||:..|.|:.........|.|..|:..:||....::..|:.:.|..          |.||
 Worm    21 ENEQAKSSFASKLLELPVSKLLQKCRSSTITVDDLPILEEKQCSNRVMSGF----------KWKK 75

  Fly    76 KKTPSLL----KASMNVFGWRL-------AGLGLVLFILEIGFRVTQPLF----LGGLVAYYADA 125
            :...|:|    |:....|.:|:       |.:.|:.:::: ...::..||    :..|:.::.  
 Worm    76 RVIFSILMKFWKSFAGAFAFRMCAIFADYASILLLKYLID-SAEISATLFNFFIIAVLILFFM-- 137

  Fly   126 SNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGD 190
                   |.|:.|  |||           |.|::|...:.|..  .:.::|.:|||.|: :...|
 Worm   138 -------QLKSLL--LGV-----------HTYLVGEDSVEMVT--VLNNIIVKKALHLT-SENTD 179

  Fly   191 TTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLL----FIP 251
            ....::..|::.....:...:.::::.....:|:.|..:.::..:|......|.::.|    |..
 Worm   180 WNRSKISKLLTTHSEAVSNGLAYVHHSCSALIELTIALFWIWETLGTRTIIVVLIVALVYAVFNI 244

  Fly   252 LQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVN 316
            :.:|:.||:..::||.   .||||.....:::.::.|||::||..|.|.:..:|.||::..|...
 Worm   245 IDSYVYKKSLKVQLKC---RDERVEFEKTVLNSMETIKMFSWEPHFWKKLKSMRGKELSVFRKTL 306

  Fly   317 YIRGTLQSFIMFVTRISVFV-SLVGFVLLG-----KLLTAEKAFVITAYYNILRNTMTVYFPMGI 375
                ::.||:..:...|.|| :.|.|.:.|     ..|..|.|||:.|.:|.:|..:.|..|   
 Worm   307 ----SINSFMHSLNVTSPFVITFVSFAVYGLQYEISALRFEDAFVLIAIFNYMRRPLHVIIP--- 364

  Fly   376 SQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAE 440
                                       |.::.::.|..|.:|.:..:.:.:..:...:......|
 Worm   365 ---------------------------SLEIVDKALHSATIINQFLIVKQSPKINTKTAPQPPVE 402

  Fly   441 HSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVN 505
            ..:.|..|.|.:.....|:||:::.:..|..:..|.||....|||||:.::.|||....|::.|:
 Worm   403 PDLDIKILNANFSWNGKDDTLNDVCVHVKKGEKHAFIGFPLCGKSSLLFSITGELKMTKGNMWVS 467

  Fly   506 GTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSG 570
            ..:|:|...|::|:.::::|||||....|.:|..|:..|.|::|...||..:.|::|::|..|:.
 Worm   468 KGISFAPASPYIFSQSLKENILFGNDYVKSKYDKVIMACDLKKDIFSLPRCEATVLGDKGYVLTS 532

  Fly   571 GQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM--RGFLREEIVLLVTHQLQFLEQA 633
            .|||:|||||.:|..||||.||.....:|......:|.:.:  .|:||::.|:|.|:.::.::..
 Worm   533 TQKAQISLARCLYEDADIYALDKAFGPMDRTTSNKIFTRVLGENGYLRDKTVILATNNIELIKTF 597

  Fly   634 DVIVIMDKGKISAMGTYESMAKSGLDFAQMLT----DPSKKDEGAGDAPDKKSLSRQNSKLRDRH 694
            .::.::..|||...|:|:.:.:.....:.:|.    |...:::.:.:.|.:|::...:..|:.|.
 Worm   598 TMVHVLKNGKIETSGSYDQILECSEIMSDLLNQSRIDKIIEEKYSDEKPPRKTVMFDDKVLKKRK 662

  Fly   695 GSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCI------GAQV 753
            .. .|||..|       |:      .|.|   .:|..||.:   |.||..||:.:      ..|.
 Worm   663 KK-QSMEDTA-------PV------FENR---SVYPFYFRS---GSFIFTAFYIVLLICRFVFQA 707

  Fly   754 LASGGDIFLSYWVN---KNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLV 815
            ||.   .:||:|::   |..|.|...     :..|.:|          :.:|.   :|.||.:::
 Worm   708 LAF---FWLSFWLDPVWKKVECENCP-----QYVFIQT----------MSFFA---ISAIISTML 751

  Fly   816 RSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQI 880
            ....|....:::|..|:..:...:....|.|.:......::|..:.||..||...|.......:.
 Worm   752 SYTFFVLTNVQTSRKLYQHITSAIFAVPMIFLSPTNKESLMNMITSDLDIVDTQFPLFFKFSFEC 816

  Fly   881 FLAIVGIVVVLCI-INVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNG 944
            .|.|:.|..::|: :.|:.|....||:.:..||| ::|.....:..||...|.............
 Worm   817 TLHILMIFAIVCVNVPVFAIFVVAFLIFLVGLLR-YFLPALHKISSLEEQKRDLFLCGSIEDFEA 880

  Fly   945 LATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGY----WLD-----------CVCVVYI 994
            ...:|.||..::.:|:.....|:        |...|...|    |:.           |:| .:|
 Worm   881 RIMVRTFGKTRQTLAKTSVNADI--------LTRCRMARYSTLRWISLRTEFISNLMICMC-FFI 936

  Fly   995 AVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFE 1059
            |.|.|.....   ......|::...:.::.:|...:|.:..||:....|:|:....:..      
 Worm   937 ASICLKVDYI---GNAQFALSVASILCISELVSTFIRTTCILESLTPHVQRISNVREYP------ 992

  Fly  1060 SKPNKKPPKD-------WPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAG 1117
                |:|..|       ||:||||...:|::  |.:|.. :|::.:::.||..||:||:|:.|:|
 Worm   993 ----KEPMIDKCTIRDSWPDDGKIEIKNLNV--FANKYR-HVIKDVSLVIEEREKLGIIGKVGSG 1050

  Fly  1118 KSSLINALFRLSY--NEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSD 1180
            ||.|...|..:|.  .|..|::|..|..::.:..|||:|::|||:..:||.|:|.|:||..:::|
 Worm  1051 KSQLAKTLVMMSSADKESHIVVDDLDIFEMSVKTLRSRITVIPQKAKIFSDTLRSNIDPCCQFAD 1115

  Fly  1181 AKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVD 1245
            :.:|.::|..:|::.|..||.||...:|.  ...|..|:..|.:.||:|:..:|.|:|::|..:.
 Worm  1116 SDIWLAIEACQLREYVKSLPDGLHQMVSP--EKMSNEQKCQVNVCRALLKGGQIFVIDQSTKMMK 1178

  Fly  1246 PQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLT 1300
            ....:|:...|||..|..|.:.|......|...|:|:|::.|..:...:|..|::
 Worm  1179 EPIKSLVNEAIRNSLKQSTTIWIGEDFSDVEHCDRVVVIENGVILTTDTPQNLIS 1233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 323/1352 (24%)
ABC_membrane 98..367 CDD:294371 63/282 (22%)
ABCC_MRP_domain1 443..643 CDD:213217 64/201 (32%)
ABC_membrane 799..1027 CDD:294371 46/243 (19%)
ABCC_MRP_domain2 1074..1295 CDD:213211 71/222 (32%)
cft-1NP_504463.1 MdlB 76..631 CDD:224055 146/617 (24%)
ABC_membrane 93..359 CDD:294371 66/298 (22%)
P-loop_NTPase 407..607 CDD:304359 64/199 (32%)
ABC_membrane 696..938 CDD:294371 53/272 (19%)
P-loop_NTPase 1010..1228 CDD:304359 71/222 (32%)
EcfA2 1012..1234 CDD:224047 71/227 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160157419
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.850

Return to query results.
Submit another query.