Protein Alignment CG4562 and pgp-1

DIOPT Version :9

• Sequence 1: NP_001262747.1
• Gene: CG4562 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_502413.1
• Gene: pgp-1 / 178215
• WormBaseID: WBGene00003995
• Length: 1321
• Species: Caenorhabditis elegans
• Alignment Length: 1457
• Identity: 319/1457 - (21%)
• Similarity: 597/1457 - (40%)
• Gaps: 334/1457 - (22%)

  Fly    38 KTLDENDL---------YRALQEHRSDHLGS----KLSAAWEKEVEKK----RKKKKTPSLLKAS 85
            :|||...|         .:.::::..|::.|    |::...::||..|    :..:.|.:|.|..
 Worm    12 RTLDSFSLAPEDVLKTAIKTVEDYEGDNIDSNGEIKITRDAKEEVVNKVSIPQLYRYTTTLEKLL 76

  Fly    86 MNVFGWRLA---GLGLVLFILEIGFRVTQPLFLGGLVAYYADASN--QEGDNQTKAYLYALGVIL 145
            :.: |..:|   |.||.|..:..| :|:| .|:...:....:.|.  ..|.|.||....
 Worm    77 LFI-GTLVAVITGAGLPLMSILQG-KVSQ-AFINEQIVINNNGSTFLPTGQNYTKTDFE------ 132

  Fly   146 TSACNVLFMHPYM-LGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDV 209
            ....||::.:..| :||:..|   :|.:|..:|                  |...::|.:.|..|
 Worm   133 HDVMNVVWSYAAMTVGMWAAG---QITVTCYLY------------------VAEQMNNRLRREFV 176

  Fly   210 -SVIHMNYLWLGPVEIGIITYLMY-----------REIG-----ISAF---FGVA---------V 245
             |::.....|......|.:...::           .:||     :|.|   |.||         |
 Worm   177 KSILRQEISWFDTNHSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFTHSWQLTLV 241

  Fly   246 MLLFIPLQAYLG----KKTSVLRLKTALRTDERVRMMNEIISGIQVI----------KMYAWEIP 296
            ||...|:||..|    |..|...::..||..:..:::.|.||.|:.:          :.|:..:.
 Worm   242 MLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNGLRYELERYSTAVE 306

  Fly   297 FSKMINYVRTKEMNAIRNVNYIRGTLQ--SFIMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAY 359
            .:|....::    .....:::  |.:|  :||.|.  ::.::. ||:|..|.|...:   ::|.:
 Worm   307 EAKKAGVLK----GLFLGISF--GAMQASNFISFA--LAFYIG-VGWVHDGSLNFGD---MLTTF 359

  Fly   360 YNILRNTMTVYFP------MGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIA 418
            .:::..:|.:...      :|.:|.|...:             .:|.|:...:|..  .|||
 Worm   360 SSVMMGSMALGLAGPQLAVLGTAQGAASGI-------------YEVLDRKPVIDSS--SKAG--- 406

  Fly   419 EPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSG 483
                           |:..:.:..|.:..:...:..:.....|..::|:....|.||::|..|.|
 Worm   407 ---------------RKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCG 456

  Fly   484 KSSLIQAVLGELNPDSGSVKVNG-------------TLSYASQEPWLFTGTVRQNILFGLP-MDK 534
            ||::|..:|...:...|.:.::|             .::..||||.||..|:.:||..|.. :.:
 Worm   457 KSTIISLLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITR 521

  Fly   535 HRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVD 599
            .......|....|:..:.||....|:||:||..||||||.||::|||:.|...|.|||:..||:|
 Worm   522 EEMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALD 586

  Fly   600 TH---VGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYES-MAKSGLDF 660
            ..   :.:...|:..:|    ...:::.|:|..:..||:|:....|::..:|.:.: ||:.||.:
 Worm   587 AESEGIVQQALDKAAKG----RTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYY 647

  Fly   661 ----AQMLTDP---------SKKDEGAGDAPDKKSLSRQNSKLRD-----RHGSISSMESA---- 703
                ||..||.         |:::..|....:.:.||||.|::.|     |..:|.|:.:.
 Worm   648 DLVTAQTFTDAVDSAAEGKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGPVID 712

  Fly   704 -AESLAAESPMQTQEGRVEGRIGMK--LYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYW 765
             .|....:..:...:..:|.....|  |::..:.|..:.|.:.     ||......||.|:.:|.
 Worm   713 EKEERIGKDALSRLKQELEENNAQKTNLFEILYHARPHALSLF-----IGMSTATIGGFIYPTYS 772

  Fly   766 VNKNGEAERDTFMARLRRAFPETRINADTDPVDIY---YFTGINVSVIIFS--LVRSMLFFYLAM 825
            |          |.......|.       .:|.|..   :|..:...|:..:  :...::.|::.:
 Worm   773 V----------FFTSFMNVFA-------GNPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGI 820

  Fly   826 RSST---TLHNTMFQGVTRAAMHFFNT--NPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIV 885
            .|.:   .|.|.:|:.|....:.||::  |.||:|..|.:.|   |..:..::......:...:|
 Worm   821 ASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKISTRLATD---VPNLRTAIDFRFSTVITTLV 882

  Fly   886 GIV--VVLCIINVWYILATVFLVIVFYLLRVF--YLS----TSRDVKRLEAVTRSPIYSHLSASL 942
            .:|  :.|.....|.:   ..|:|....:..|  ||.    |.::||.......|...:  ..::
 Worm   883 SMVAGIGLAFFYGWQM---ALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIA--IEAI 942

  Fly   943 NGLATIRAFGAQKELIAEFDNYQDM-HSSGYYMFLATSRAF--GYWLDCVCVVYIAVITLSFFLF 1004
            ..:.|::|...:......|....|: |..      |...||  |....|...|...:.|.::
 Worm   943 ENVRTVQALAREDTFYENFCEKLDIPHKE------AIKEAFIQGLSYGCASSVLYLLNTCAY--- 998

  Fly  1005 SPENGGDVGLAI-----------------------TQAMG-------------MTGMVQWGM-RQ 1032
                  .:|||:                       |..:|             ..|.:.:|| |:
 Worm   999 ------RMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRK 1057

  Fly  1033 SAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRS 1097
            .:::::...|.|:...|                        ||::|.::...| |::....:|:.
 Worm  1058 ISKIDSLSLAGEKKKLY------------------------GKVIFKNVRFAY-PERPEIEILKG 1097

  Fly  1098 LNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNE--GAILIDRRDTNDLGLHDLRSKISIIPQE 1160
            |:.::|..:.:.:||.:|.|||::: ||....|:.  |.|.||..:...|.....||:|:|:.||
 Worm  1098 LSFSVEPGQTLALVGPSGCGKSTVV-ALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQE 1161

  Fly  1161 PVLFSGTMR----YNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQL 1221
            |.||..::.    |.||| ...:.|::.|:.....:...:|:||.|.::::.:.||..|.||:|.
 Worm  1162 PTLFDCSIAENIIYGLDP-SSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQR 1225

  Fly  1222 VCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDA 1286
            :.:|||::|..:||::||||:.:|.:::.::|..:....:..|.:.|||||:|||::|.:.|:..
 Worm  1226 IAIARALVRNPKILLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADCIAVVSN 1290

  Fly  1287 GKAVEFGSPFELLTTSEKKVFHSMVKQ 1313
            |..:|.|:..:|:  |||..::.:.::
 Worm  1291 GTIIEKGTHTQLM--SEKGAYYKLTQK 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	316/1442 (22%)
		ABC_membrane	98..367	CDD:294371	62/316 (20%)
		ABCC_MRP_domain1	443..643	CDD:213217	60/216 (28%)
		ABC_membrane	799..1027	CDD:294371	48/284 (17%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	73/226 (32%)
pgp-1	NP_502413.1	PTZ00265	38..1311	CDD:240339	315/1425 (22%)
		ABC_membrane	81..367	CDD:279056	65/326 (20%)
		ABC_MTABC3_MDL1_MDL2	416..653	CDD:213216	66/240 (28%)
		ABC_membrane	760..1028	CDD:279056	54/307 (18%)
		ABC_MTABC3_MDL1_MDL2	1077..1316	CDD:213216	75/244 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910