DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and pmp-2

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_495408.1	Gene:	pmp-2 / 174127	WormBaseID:	WBGene00004059	Length:	661	Species:	Caenorhabditis elegans

Alignment Length:	699	Identity:	152/699 - (21%)
Similarity:	261/699 - (37%)	Gaps:	173/699 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LYRALQEHRSDHLGSK-LSAAWEKEVEKKRKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFR 108
            ::..::.::.|..|:| |.|..:|:..|.:|           .:|.|..|..|..:|.||..||.
Worm    29 VFALIKLYKQDIRGTKHLVAKTKKDGSKGQK-----------AHVDGVFLGKLARILKILIPGFF 82

  Fly   109 VTQPLFL-----GGLVAYYAD------ASNQEG---DNQ-----TKAYLYALGVILTSACNVLFM 154
            ..:..:|     ..|...|||      ::..|.   |..     .:|:.|.|.:...|..|.:.
Worm    83 SKESFYLILIAVSLLCRTYADVYMIITSTKIEASIIDRNPLLFALEAFKYVLNLPAISVTNAIL- 146

  Fly   155 HPYMLGMFHIGMKARIAMTSMIYRKALR---LSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNY 216
               ..|:..:.::.|..:::.:|.:.|:   ..:.:..||.|.....|::.||.|....::.: |
Worm   147 ---KFGIAELKLRFRERLSTHLYSQYLKGFTFYKMSNLDTRIQNADQLLTQDVDRFCDGIVEL-Y 207

  Fly   217 LWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEI 281
            ..|....:.:..||.  .:|.|..|. :..:||..| .:.|...:.||......|.|...:..|
Worm   208 SNLSKPILDVFLYLF--RLGTSLGFS-SPSILFSYL-LFTGVGLTYLRRPIGRLTVEEQALEGE- 267

  Fly   282 ISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRG----------TLQSFIMFVTRISVFV 336
                               ..||.::.:.....:.:.:|          |..|.:..:.:|.:|.
Worm   268 -------------------YRYVNSRLIMNSEEIAFYQGNQSEKETIMSTFASLVQHLRKIILFR 313

  Fly   337 SLVGFV--LLGKLLTA---------------EKAFV-------ITAYYNILRNTMTVYFPMGISQ 377
            ..:|||  ::.|.|..               .|.|:       :..|||..|  |.......:.:
Worm   314 FSIGFVDNIVAKYLATVVGWYAVGSSFFDKQHKPFIGMSRNQLMQEYYNSGR--MMYKMAEALGR 376

  Fly   378 FAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLG--KAGLIAEPTVAQTTGVLKPSSRRTSEAE 440
            .|.....:.|:..|....:|.:    ..||:...|  |..::.|                 .|..
Worm   377 LALAGRDMTRLSGFTSRVDTLL----NVLDDVNSGNYKRTMVGE-----------------KEES 420

  Fly   441 HSIVISKLKA------------KWDQ-----KNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLI 488
            .:::.|:|.|            ::|.     .|.|..::.::.:......|.|.||.|.|||||.
Worm   421 SALIKSELVAGSGNLRVQDNVIRFDNVPLVTPNGDVLIERLNFEVPSGTNVLVCGPNGCGKSSLF 485

  Fly   489 QAVLGELNPDSGSV---KVNGTLSYASQEPWLFTGTVRQNILF-GLPMDKHRYRTVVKRCALERD 549
            : |||||.|..|..   ...|.|.|..|.|::..||:|..|:: ..|:|      ::::...:.|
Worm   486 R-VLGELWPLFGGTLTKPAKGKLFYVPQRPYMTLGTLRDQIIYPDRPLD------MIRKGVSDSD 543

  Fly   550 FE-LLPYADKTIVGERGAS----------LSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVG 603
            .| :|.....|.:.||...          ||||:|.||::||..|.|....:||:..|||...|.
Worm   544 LEQMLENVQLTHILEREGGWSAVQDWMDVLSGGEKQRIAMARLFYHKPQFAILDECTSAVSVDVE 608

  Fly   604 RHLFDQCMRGFLREEIVLL--VTHQLQFLEQADVIVIMDKGKISAMGTY 650
            ..::..|     ||:.:.|  |:|:....:..:..:.||     ..|:|
Worm   609 GAMYRLC-----REKNITLFTVSHRKSLWKYHEYSLYMD-----GRGSY 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	152/699 (22%)
		ABC_membrane	98..367	CDD:294371	62/324 (19%)
		ABCC_MRP_domain1	443..643	CDD:213217	65/233 (28%)
		ABC_membrane	799..1027	CDD:294371
		ABCC_MRP_domain2	1074..1295	CDD:213211
pmp-2	NP_495408.1	3a01203	1..649	CDD:273360	152/699 (22%)
		ABC_membrane_2	62..341	CDD:284003	60/307 (20%)
		ABCD_peroxisomal_ALDP	442..647	CDD:213190	63/221 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910