DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and Abcc1

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_032602.1	Gene:	Abcc1 / 17250	MGIID:	102676	Length:	1528	Species:	Mus musculus

Alignment Length:	1404	Identity:	492/1404 - (35%)
Similarity:	751/1404 - (53%)	Gaps:	187/1404 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRK--- 74
            |...::..|.:.|.:.......|.::.|:.:||:...:|..|:.:...|...|:||.:|.||
Mouse   209 PESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPV 273

  Fly    75 ----------------------------------KKKTPSLLKASMNVFGWRLAGLGLVLFILEI 105
                                              |.:.|||.|.....||        ..|::..
Mouse   274 RIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFG--------PYFLMSF 330

  Fly   106 GFRVTQPL--FLG-GLVAYYADASNQEGDNQTKAYLYALGVILTSAC-NVLFMHPYMLGMFHI-- 164
            .::....|  |.| .::....:..|.......:.|.|. .::..||| ..|.:|.|    |||
Mouse   331 LYKALHDLMMFAGPKILELIINFVNDREAPDWQGYFYT-ALLFVSACLQTLALHQY----FHICF 390

  Fly   165 --GMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGII 227
              ||:.:.|:...:|||||.::..|...:|:|::|||:|.|..|......::|.:|..|:::.:.
Mouse   391 VSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILA 455

  Fly   228 TYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYA 292
            .|.::..:|.|...|||||:|.:||.|.:..||...::......|.|:::||||::||:|:|:||
Mouse   456 LYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYA 520

  Fly   293 WEIPFSKMINYVRTKEMNAIRNVNYIR--GTL----QSFIMFVTRISVFVSLVGFVLLGKLLTAE 351
            ||:.|...:..:|.:|:..::...|:.  ||.    ..|::.::..:|||:    |....:|.|:
Mouse   521 WELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVT----VDERNILDAK 581

  Fly   352 KAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGL 416
            ||||..|.:||||..:.: .||.||...:..||::|::.|:.|||
Mouse   582 KAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEE-------------------- 625

  Fly   417 IAEPTVAQTTGVLKPSS--RRT--SEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVI 477
                        |:|.|  ||:  |...:||.:......| .:....||:.|:.......||||:
Mouse   626 ------------LEPDSIERRSIKSGEGNSITVKNATFTW-ARGEPPTLNGITFSIPEGALVAVV 677

  Fly   478 GPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVK 542
            |.||.|||||:.|:|.|::...|.|.:.|:::|..|:.|:...::|:|||||.|:.::.|:.|::
Mouse   678 GQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVME 742

  Fly   543 RCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLF 607
            .|||..|.|:||..|:|.:||:|.:||||||.|:|||||||..:||||.||||||||.|||:|:|
Mouse   743 ACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIF 807

  Fly   608 DQCM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTD---- 666
            ::.:  .|.|:.:..:||||.:.:|.|.|||::|..||||.||:|:.:......||:.|..
Mouse   808 EKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTYANA 872

  Fly   667 ----PSKKDEGAGDAPDKK------------------SLSRQNSKLRD---RHGSISSMESAAES 706
                .|:.|..:|...:.|                  .||..:|...|   :|.||:.::.|...
Mouse   873 EQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAK 937

  Fly   707 LAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFI----VFAFFCIGAQVLASGGDIFLSYWVN 767
            ......|:..:.:. |::.:.:|..|..|  .||||    :|.|.|.....|||  :.:||.|.:
Mouse   938 EETWKLMEADKAQT-GQVQLSVYWNYMKA--IGLFITFLSIFLFLCNHVSALAS--NYWLSLWTD 997

  Fly   768 K----NGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSS 828
            .    ||......|.                  :.:|...||.....||..  ||......:.:|
Mouse   998 DPPVVNGTQANRNFR------------------LSVYGALGILQGAAIFGY--SMAVSIGGIFAS 1042

  Fly   829 TTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCI 893
            ..||..:...|.|:.|.||...|||.::|||||:|..||.::|.|:...|....:::|.|:::.:
Mouse  1043 RRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILL 1107

  Fly   894 INVWYILATVF--LVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKE 956
            ...  |.|.:.  |.:|::.::.||:::||.:||||:|:|||:|||.:.:|.|::.||||..|:.
Mouse  1108 ATP--IAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQER 1170

  Fly   957 LIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCV--CVVYIAVITLSFFLFSPE--NGGDVGLAIT 1017
            .|.:.|...|.:...||..:..:|.....|:||  |:|..|.:   |.:.|..  :.|.|||:::
Mouse  1171 FIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAAL---FAVISRHSLSAGLVGLSVS 1232

  Fly  1018 QAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLS 1082
            .::.:|..:.|.:|.|:|:|..:.||||:.||.:.|.|..::.: ...||..||..|::.|.|..
Mouse  1233 YSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQ-ETAPPSTWPHSGRVEFRDYC 1296

  Fly  1083 LKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYN-EGAILIDRRDTNDLG 1146
            |:|..|  .|.||:.:|:.|||.||||||||||||||||...|||::.: ||.|:||..:...:|
Mouse  1297 LRYRED--LDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIG 1359

  Fly  1147 LHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGG 1211
            ||:||.||:||||:||||||::|.|||||.:|||.::|.:||...||..|:.||..|..:.:|||
Mouse  1360 LHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGG 1424

  Fly  1212 TNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVM 1276
            .|.|||||||||||||:||:.:|||:|||||.||.:||.|||:|||.:|:|||||||||||:|:|
Mouse  1425 ENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIM 1489

  Fly  1277 DSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            |..:|:|:|.|:..|.|:|.|||  .::.:|:||.|..|
Mouse  1490 DYTRVIVLDKGEVRECGAPSELL--QQRGIFYSMAKDAG 1526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	486/1387 (35%)
		ABC_membrane	98..367	CDD:294371	86/282 (30%)
		ABCC_MRP_domain1	443..643	CDD:213217	90/201 (45%)
		ABC_membrane	799..1027	CDD:294371	76/233 (33%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	130/221 (59%)
Abcc1	NP_032602.1	MRP_assoc_pro	7..1527	CDD:188098	492/1404 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..895		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..929		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841648
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660