DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4562 and Abcc3

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:NP_542148.2 Gene:Abcc3 / 140668 RGDID:71101 Length:1523 Species:Rattus norvegicus


Alignment Length:1405 Identity:491/1405 - (34%)
Similarity:764/1405 - (54%) Gaps:181/1405 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 PEN------PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKE 68
            |||      |...:..||.|.|.:.......|.::.|:::||:...:|..|..:..:|..||:|:
  Rat   199 PENLDTNPCPEASAGFFSRLSFWWFTKLAILGYRRPLEDSDLWSLSEEDCSHKVVQRLLEAWQKQ 263

  Fly    69 ----------------------VEKKRKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQ 111
                                  :.|.|.|.|.||.|:|.:..|...|. :|....:::.......
  Rat   264 QTQASGPQTAALEPKIAGEDEVLLKARPKTKKPSFLRALVRTFTSSLL-MGACFKLIQDLLSFIN 327

  Fly   112 PLFLGGLVAYYAD--ASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTS 174
            |..|..|:.:.:|  |....|      :|.|..:.::|....|.:|.:...:|.:.::.|.|:..
  Rat   328 PQLLSILIRFISDPTAPTWWG------FLLAGLMFVSSTMQTLILHQHYHCIFVMALRIRTAIIG 386

  Fly   175 MIYRKALRLSRTALGDTTIGQVVNLISNDVGR-LDVSVIHMNYLWLGPVEIGIITYLMYREIGIS 238
            :||||||.::.:...:.|:|::|||:|.|..| :|||.. :|.||..|:::.:..|.:::.:|.|
  Rat   387 VIYRKALTITNSVKREYTVGEMVNLMSVDAQRFMDVSPF-INLLWSAPLQVILAIYFLWQILGPS 450

  Fly   239 AFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINY 303
            |..||||::|.|||...:..|....:::.....|.|:::|:||::||:|:|:||||..|.:.:..
  Rat   451 ALAGVAVIVLLIPLNGAVSMKMKTYQVQQMKFKDSRIKLMSEILNGIKVLKLYAWEPTFLEQVEG 515

  Fly   304 VRTKEMNAIRNVNYIRGTLQSFIMFVTRISVFVSLVG-FVLLGK--LLTAEKAFVITAYYNILRN 365
            :|..|:..:|...|:: .:.:||...|...|.:..:| :|.:.|  :|.||||||..:.:|||:.
  Rat   516 IRQSELQLLRKGAYLQ-AISTFIWVCTPFMVTLITLGVYVCVDKNNVLDAEKAFVSLSLFNILKI 579

  Fly   366 TMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLK 430
            .:.: .|..||...:..||::|||.|:         ..::||.|.:                   
  Rat   580 PLNL-LPQLISGMTQTSVSLKRIQDFL---------NQDELDPQCV------------------- 615

  Fly   431 PSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGEL 495
              .|:|.....:|.|......| .|:...||.:::::.....||||:||||.|||||:.|:|||:
  Rat   616 --ERKTISPGRAITIHNGTFSW-SKDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEM 677

  Fly   496 NPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTI 560
            ....|:|.|.|:::|..|:.|:...|:::|:|||.||:..||:..::.|||..|.::||..|:|.
  Rat   678 EKLEGAVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTE 742

  Fly   561 VGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM--RGFLREEIVLLV 623
            :||:|.:|||||:.|:|||||||..|:|:||||||||||:||.:|:|||.:  .|.|..:..:||
  Rat   743 IGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLV 807

  Fly   624 THQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQML-----TDPSKKDEGAGDAPDKKSL 683
            ||.:.||.|.|.|:::..|:|:.||.|..:.:....||..|     .:..:.:||.....:::.|
  Rat   808 THGISFLPQTDFIIVLADGQITEMGHYSELLQHDGSFANFLRNYAPDENQEANEGVLQHANEEVL 872

  Fly   684 SRQ-----NSKLRDRHGSI-----------SSMESAAE------------SLAAESP-MQTQE-G 718
            ..:     ::.|.|...:|           ||:.|..|            ||..|.| .||:| |
  Rat   873 LLEDTLSTHTDLTDTEPAIYEVRKQFMREMSSLSSEGEGQNRPVLKRYTSSLEKEVPATQTKETG 937

  Fly   719 RV-------EGRIGMKLYKKYFGANGYGLFIVFAFFCI---GAQVLASGGDIFLSYWVNKNGE-A 772
            .:       .|.:.:.:|..|  |...||.... |.|:   |...:|.|.:::||.|.|...| .
  Rat   938 ALIKEEIAETGNVKLSVYWDY--AKSVGLCTTL-FICLLYAGQNAVAIGANVWLSAWTNDVEEHG 999

  Fly   773 ERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVII----FSLVRSMLFFYLAMRSSTTLHN 833
            :::....||                .:|...||...:::    |::|..      |::::..||.
  Rat  1000 QQNNTSVRL----------------GVYATLGILQGLLVMLSAFTMVVG------AIQAARLLHT 1042

  Fly   834 TMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEIL-PSVMMDVMQIFLAIVGIVVVL------ 891
            .:.....||...||:|.||||||||||||:..:||:| |:::|.....:.:|..|||::      
  Rat  1043 ALLHNQIRAPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLFNSFYTSISTIVVIVASTPLF 1107

  Fly   892 CIINVWYILATVFLVIVFY-LLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQK 955
            |::        |..:.||| .::.||::|||.:||||:|:||||:||.|.::.|.:.|||:|..:
  Rat  1108 CVV--------VLPLAVFYGFVQRFYVATSRQLKRLESVSRSPIFSHFSETVTGTSVIRAYGRVQ 1164

  Fly   956 ELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCV--CVVYIAVITLSFFLFSPE--NGGDVGLAI 1016
            :.....|...|.:....|.::|::|..|..::.|  |||..:.:   |.:....  |.|.|||::
  Rat  1165 DFKVLSDAKVDSNQKTTYPYIASNRWLGVHVEFVGNCVVLFSAL---FAVIGRNSLNPGLVGLSV 1226

  Fly  1017 TQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDL 1081
            :.|:.:|..:.|.:|..::||:.:.|||||.||...|.|..:..:.| :.|:.||..|.:.|.:.
  Rat  1227 SYALQVTLSLNWMIRTLSDLESNIIAVERVKEYSKTETEAPWVLESN-RAPEGWPRSGVVEFRNY 1290

  Fly  1082 SLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFR-LSYNEGAILIDRRDTNDL 1145
            |::|.|  ..:.||::|.:.::|.|||||||||||||||:...||| |...||.|.||..:...:
  Rat  1291 SVRYRP--GLELVLKNLTLHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIFIDGLNVAHI 1353

  Fly  1146 GLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEG 1210
            |||||||:::||||:|:|||||:|.|||||..|||..:|.:||...|...|:..|:||..:.|||
  Rat  1354 GLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSDEDIWRTLELSHLSAFVSSQPTGLDFQCSEG 1418

  Fly  1211 GTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTV 1275
            |.|.|||||||||||||:||::|:||:|||||.:|.:||.|||.|||.:|:|||||||||||:|:
  Rat  1419 GDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTI 1483

  Fly  1276 MDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            ||.::|||:|.|...||.||..|:...  .:|:.|.|..|
  Rat  1484 MDYNRVLVLDKGVVAEFDSPVNLIAAG--GIFYGMAKDAG 1521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 485/1386 (35%)
ABC_membrane 98..367 CDD:294371 83/274 (30%)
ABCC_MRP_domain1 443..643 CDD:213217 92/201 (46%)
ABC_membrane 799..1027 CDD:294371 79/243 (33%)
ABCC_MRP_domain2 1074..1295 CDD:213211 126/221 (57%)
Abcc3NP_542148.2 MRP_assoc_pro 7..1522 CDD:188098 491/1405 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345002
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.660

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