DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and AgaP_AGAP007917

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_317569.4	Gene:	AgaP_AGAP007917 / 1278042	VectorBaseID:	AGAP007917	Length:	1487	Species:	Anopheles gambiae

Alignment Length:	1343	Identity:	407/1343 - (30%)
Similarity:	680/1343 - (50%)	Gaps:	116/1343 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EKSNIFSSLMFCFAMPTFFKGRKKTLDEN----DLYRALQEHR-SDHLGSKLSAAWEKEVEKKRK 74
            :.:|:.|..:|.:..|...|.....|..|    ||..||..|| ::.|.:.||
Mosquito   221 DDANLLSKFVFYWVRPLIAKAVSGKLKRNDDLFDLPEALTLHRVTEKLQTALS------------ 273

  Fly    75 KKKTPSLLKASMNVFGWRLAGLGLVLFILEI-GFRVTQPLFLGGLV--------AYYADASNQEG 130
              :|.|||||....|||....:||:..:.:: ||  ..||.||.|:        ....|.::..|
Mosquito   274 --ETSSLLKALHKCFGWEFYLIGLLRLLGDLSGF--AGPLLLGALLRMEINGNSTVPIDPADSSG 334

  Fly   131 DNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQ 195
            .:...||.:|||:..::..:......:...|..:..|.|:::.:.||:|:|...:.   .....:
Mosquito   335 SSDFVAYYHALGLFGSAMISAFAAVHFNWRMTFVSSKMRMSIVTAIYQKSLTAKQL---QAARPE 396

  Fly   196 VVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKT 260
            ::||:|.|..|:..|.|..:..|..|.::....||:|.::|::...||...:|.||:...:.:|.
Mosquito   397 ILNLMSTDTDRIVNSCISFHSFWSIPFQLFTTLYLLYTQLGVAFVAGVLFAVLLIPINRKIAQKI 461

  Fly   261 SVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSF 325
            ..|........|.||.:..|.|||.:.||:.|||..|...|:..|.:|::.:....|:....
Mosquito   462 GQLSQGLMAAKDARVTITTETISGAKDIKLNAWEDVFISKIHRERGEEISFLAKRKYLDALC--- 523

  Fly   326 IMFVTRISVFVSLVGF---VLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRR 387
            :.|.....|.:.|..|   :||||.|||...:...|..|:|...:.. ||..::...|..||::|
Mosquito   524 VYFWATTPVLMCLFTFGTSILLGKPLTAATTYTSVALLNMLIGPLNA-FPWVLNGLTEAWVSLKR 587

  Fly   388 IQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTV-AQTTGVLKPSSRRTSEAEHSIVISKLKAK 451
            :|..:...:..::|....|.......|.....|.| |...|..:..::| |..|..:|
Mosquito   588 VQELLDLPDVNLQDYYRPLTASDAAFANSSKRPVVLAIKDGSFEFETKR-SRKELDLV------- 644

  Fly   452 WDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTL----SYAS 512
             .:...|....:::|:.:..:||.:.||||.|||||:|.::|.....:|:|.::..:    .|.:
Mosquito   645 -QEDIIDFAFRDLTLQVRQGELVCLEGPVGGGKSSLLQVIMGYFQCTAGAVAISMDVKEGFGYVA 708

  Fly   513 QEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARIS 577
            |.|||..||:|.|||:|...|:.||:.|:..|||:.|.:.| ..|.|.|||:|.:||||||||::
Mosquito   709 QTPWLQQGTIRDNILWGEIYDETRYKAVIHACALQYDLDAL-RGDSTGVGEQGRTLSGGQKARVA 772

  Fly   578 LARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKG 642
            ||||||:...||||||.|||:|.||..|:...|:.|.|:::..::||.....|.:|..|:.::.|
Mosquito   773 LARAVYQNKSIYLLDDILSALDAHVASHIIRHCLFGLLKDKTRIIVTQHSMVLNRATQILHVEAG 837

  Fly   643 KISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAAESL 707
            :::     :|.|.   :...:|:|....||..     ..:||..|...     |..|:....:..
Mosquito   838 QVT-----QSDAP---NVGSLLSDYDDYDEDT-----STTLSMANGST-----SYGSVREDDDQR 884

  Fly   708 AAESPMQTQEGRVEGRIGMKLYKKYFGANG--YGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNG 770
            :.:|.:. :|.|..|.:..|:...|:.|.|  .|.:::.:...:  ||..:..|.:|:|||.
Mosquito   885 SNDSVLM-EESREFGHLDQKVLGAYWKATGRSLGFWVIMSVLMM--QVSRNLTDAWLAYWVG--- 943

  Fly   771 EAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVII----FSLVRSMLFFYLAMRSSTTL 831
                |..:|.:..|......:........:|:.|:..::.|    .:|:|:.||.|..::::..:
Mosquito   944 ----DGVLAMVDHALLPILTDGSNGTATPFYYLGVYATLAISNSLLTLLRAFLFAYAGLKAAKCI 1004

  Fly   832 HNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINV 896
            |:.:...|....:.||:..|.||||||||.|:..||:.||.:...::..|..::|.:::......
Mosquito  1005 HDRLLNSVLYTKLQFFDVVPLGRILNRFSSDVYAVDDTLPFITNILLAQFFGLLGALLISLYAMP 1069

  Fly   897 WYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEF 961
            |..|..|.||.::..|:..|...|||:|||.:...||:|:|.:.:|.||.||||...:|....:|
Mosquito  1070 WLGLLIVPLVPIYLSLQNKYRFASRDIKRLSSNALSPLYAHFTETLQGLTTIRALRGEKRFQRDF 1134

  Fly   962 -----DNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYI------AVITLSFFLFSPENGGDVGLA 1015
                 ::.:...|:.     ||.:..|..|..:....:      |.|| |..:.|||.   ||||
Mosquito  1135 LYKLGESIKSQLSAA-----ATQQWLGLRLQLLGAFLVGGSGLLAAIT-SAHMTSPEL---VGLA 1190

  Fly  1016 ITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDD 1080
            |:.|:.:||::...:...||.|....||||:.:|..||||  ..:..:..||..||..|.:|||:
Mosquito  1191 ISYALSITGLLSGLLYAVAETEQEFVAVERINQYCQLEPE--INADGSADPPFGWPSQGVVVFDN 1253

  Fly  1081 LSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLS-YNEGAILIDRRDTND 1144
            :.::|.......  :||:|:.::.||::.||||||:||:|::.:|.|:: .::|.|.:|..:...
Mosquito  1254 VHMRYREHLTCS--IRSINLNVKPCERISIVGRTGSGKTSVLASLLRVAPLDKGTIAVDFVNIAT 1316

  Fly  1145 LGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISE 1209
            |.|..|||:|::|.|:|.||:||:|.||||...:.|:::||::.......:|..| .||..::..
Mosquito  1317 LPLDVLRSRIALISQDPFLFNGTIRDNLDPRAVHIDSEIWEAINCCLASPLVQAL-GGLYGRLDV 1380

  Fly  1210 GGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHT 1274
            .|.|.|.||:||:||.||:|::::|:::||.|:|:|.::::.||..::|.|:..||:.:||||..
Mosquito  1381 SGANLSAGQKQLLCLTRALLKKSKIVLIDEGTSNLDFESESAIQLVLKNAFRGRTVIVVAHRLKG 1445

  Fly  1275 VMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTGDS 1317
            ::|:|:|.||..|...|.|.|.: |......:|:|::::..:|
Mosquito  1446 ILDTDQVFVMQDGTVNEQGVPRD-LAEQPNSLFYSLLQEQQNS 1487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	403/1324 (30%)
		ABC_membrane	98..367	CDD:294371	73/280 (26%)
		ABCC_MRP_domain1	443..643	CDD:213217	80/203 (39%)
		ABC_membrane	799..1027	CDD:294371	74/242 (31%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	85/221 (38%)
AgaP_AGAP007917	XP_317569.4	MTABC_N	13..>162	CDD:292803
		CFTR_protein	218..1462	CDD:273530	400/1315 (30%)
		ABC_membrane	329..568	CDD:294371	64/244 (26%)
		ABCC_MRP_domain1	623..838	CDD:213217	85/224 (38%)
		ABC_membrane	957..1205	CDD:294371	74/256 (29%)
		ABCC_MRP_domain2	1247..1466	CDD:213211	85/221 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820