DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and Abcc2

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_038834.2	Gene:	Abcc2 / 12780	MGIID:	1352447	Length:	1543	Species:	Mus musculus

Alignment Length:	1416	Identity:	486/1416 - (34%)
Similarity:	771/1416 - (54%)	Gaps:	187/1416 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEK------ 71
            |...::..||:.|.:...|..||.|..|...|::...:..::..|.||......|:::|
Mouse   193 PSATASFLSSVTFSWYDSTVLKGYKHPLTIEDVWDIEENLKAKSLTSKFKTIMTKDLQKARQALQ 257

  Fly    72 ---------------------------------KRKKKKTPS--------LLKASMNVFGWRLAG 95
                                             |:||||:.:        |:||....|...:
Mouse   258 RRLKKSQQSPEGTSHGLTKKQSQSQDVLVLEDSKKKKKKSEATKDFPKSWLVKALFKTFYVVI-- 320

  Fly    96 LGLVLFILEIGFRV---TQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPY 157
              |..|||::...:   ..|..|..|:.:..|..:.    ....|:||:.:...:.....|:..|
Mouse   321 --LKSFILKLAHDILLFLNPQLLKFLIGFVKDPDSY----PWVGYIYAILMFSVTLIQSFFLQCY 379

  Fly   158 MLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRL-DV-SVIHMNYLWLG 220
            ....|.:||..|..:.:.:|:|||.||..|....|||:.|||:|.|..:| || :.||:  ||..
Mouse   380 FQFCFVLGMTVRTTIIASVYKKALTLSNLARRQYTIGETVNLMSVDSQKLMDVTNYIHL--LWSS 442

  Fly   221 PVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGI 285
            .::|.:..:.::||:|.|...||.:|:|.:|:...|..|...::::.....|:|:::||||:|||
Mouse   443 VLQIALSIFFLWRELGPSILAGVGLMVLLVPVNGVLATKIRKIQVQNMKNKDKRLKIMNEILSGI 507

  Fly   286 QVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIR-GTLQSFIMFVTRIS-VFVSLVGF---VLLG 345
            :::|.:|||..|.:.:|.:|.||:.     |.:| ..||:.::|:..:: ..||::.|   ||:.
Mouse   508 KILKYFAWEPSFKEQVNSIRKKELR-----NLLRFSQLQTILIFILHLTPTLVSVITFSVYVLVD 567

  Fly   346 --KLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDE 408
              .:|.|||||.....:||||..:.: .||.||...:..||:.|::.::         .|:|||.
Mouse   568 SQNVLNAEKAFTSITLFNILRFPLAM-LPMVISSVIQASVSVDRLEQYL---------GSDDLDL 622

  Fly   409 QKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQL 473
            ..:                      |.....:.::..|:....|| ::.:.|:.:::|..||.||
Mouse   623 SAI----------------------RHVCHFDKAVQFSEASFTWD-RDLEATIQDVNLDIKPGQL 664

  Fly   474 VAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYR 538
            |||:|.|||||||||.|:|||:....|.:.:.|:::|..|:.|:..||::.|||||...|:.:|:
Mouse   665 VAVVGTVGSGKSSLISAMLGEMENVHGHITIKGSIAYVPQQAWIQNGTIKDNILFGSEYDEKKYQ 729

  Fly   539 TVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVG 603
            .|::.|||..|.|:||..|...:||:|.:||||||.|:|||||.|:.||||:|||||||||||||
Mouse   730 RVIEACALLPDLEMLPGGDMAEIGEKGINLSGGQKHRVSLARATYQDADIYILDDPLSAVDTHVG 794

  Fly   604 RHLFDQCM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYES-------------- 652
            :|:|::.:  .|.|..:..:||||.:.||.|.|.||::.||.|...|:|..
Mouse   795 KHIFNKVVGPNGLLSGKTRILVTHGIHFLPQVDEIVVLGKGTILEKGSYSDLMDKKGVFAKNWKT 859

  Fly   653 -MAKSGLDFAQMLTDPSKKDEG-------AGDAPD-------------KKSLSRQNSKLRDRHG- 695
             |..||.:....:.:.|::::|       ..:.||             :::||| :|:...|.|
Mouse   860 FMKHSGPEGEATVDNDSEEEDGDCGLIPTVEEIPDDAASLTMRRENSLRRTLSR-SSRSGSRRGK 923

  Fly   696 ---------SISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGA 751
                     |::::....|.:..:..:: :|....|::...:|.||..|.|:...:....|.:..
Mouse   924 SLKSSLKIKSVNALNKKEEVVKGQKLIK-KEFVETGKVKFSIYLKYLQAVGWWSLLFIVIFYVLN 987

  Fly   752 QVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDP----VDIYYFTGINVSVIIF 812
            .|...|.:::||.|.:.:                 |.:...|..|    :.|..|..:.::..||
Mouse   988 YVAFIGTNLWLSAWTSDS-----------------EKQNGTDNSPSQRDMRIGVFGALGIAQGIF 1035

  Fly   813 SLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDV 877
            .|..|:...|....:|.|||..:...:.||.|.||:|.|:|||:|||:.|:..||:.||..:...
Mouse  1036 LLSSSLWSIYACRNASKTLHRQLLTNILRAPMSFFDTTPTGRIVNRFAGDISTVDDTLPQTLRSW 1100

  Fly   878 MQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASL 942
            :..|..||..:|::|:....:|:..:.|.|::..::|||::|||.::||::||:||||||.|.::
Mouse  1101 LLCFFGIVSTLVMICMATPIFIIIIIPLSILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETV 1165

  Fly   943 NGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCV--CVVYIAVITLSFFLFS 1005
            :||..||||..|:..:|..:...|.:....:.::.::|.....|:.|  .:|:.:.:.|..:..|
Mouse  1166 SGLPVIRAFEHQQRFLANSEKQIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVIYKNS 1230

  Fly  1006 PENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDW 1070
             ..|..||..::.|:.:|..:.|.:|.::|:|..:.||||:.||.:::.|..:.:  :||||.||
Mouse  1231 -LTGDTVGFVLSNALNITQTLNWLVRMTSEVETNIVAVERINEYINVDNEAPWVT--DKKPPADW 1292

  Fly  1071 PEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNEGA- 1134
            |:.|:|.|::..::|.|:  .|.||:.:...|:..||||:|||||||||||.|.|||:..:.|.
Mouse  1293 PKKGEIQFNNYQVRYRPE--LDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQ 1355

  Fly  1135 ILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADL 1199
            |:||..|...:||||||.:::||||:|:||||.:|.|||||::|||.::|.:||...||..||.|
Mouse  1356 IIIDGIDIASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVAGL 1420

  Fly  1200 PSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCT 1264
            ..||..:::|||.|.|:|||||:||.||:||:::|||:|||||.||.:||:||||||||:|..||
Mouse  1421 QLGLLHEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRNEFSQCT 1485

  Fly  1265 VLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            |:||||||||:|||||::|:|:||.||:|||.|||  |....|:.|.|:.|
Mouse  1486 VITIAHRLHTIMDSDKIMVLDSGKIVEYGSPEELL--SNMGPFYLMAKEAG 1534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	480/1399 (34%)
		ABC_membrane	98..367	CDD:294371	89/280 (32%)
		ABCC_MRP_domain1	443..643	CDD:213217	97/201 (48%)
		ABC_membrane	799..1027	CDD:294371	74/229 (32%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	127/221 (57%)
Abcc2	NP_038834.2	MRP_assoc_pro	10..1535	CDD:188098	486/1416 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..285		0/24 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..927		6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830