DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and AgaP_AGAP008436

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_317007.3	Gene:	AgaP_AGAP008436 / 1277540	VectorBaseID:	AGAP008436	Length:	1407	Species:	Anopheles gambiae

Alignment Length:	1390	Identity:	368/1390 - (26%)
Similarity:	616/1390 - (44%)	Gaps:	227/1390 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SMKADELPENPREKSNIFSSLM-----------FCFAMPTFFKGRKKTLDEN-------DLYRAL 49
            |......|..|.....:|.|.|           ..|...|.|:|   ||.|:       :||...
Mosquito   150 SSTGSNTPRKPNFIRGLFFSWMDSTYREAHRGSVAFYQGTLFQG---TLPEDRRCEQLLELYEKA 211

  Fly    50 QEHRSDHLGSKLSAAWEKEVEK----KRKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVT 110
            ...|........|...|.|:.:    |........::.|.:|.| ..::...|..::|.:.....
Mosquito   212 NARRGYTAVDDGSGRMESELCRFTIGKLLSPFRGEIILAGLNRF-VLISLFFLCPYLLRLLLEEN 275

  Fly   111 QP-LFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTS 174
            || ::...:|....|||.                 :.:..|..:.|...    .||::.|..:..
Mosquito   276 QPRMYQKWIVTALFDAST-----------------IIAILNTHYQHTTQ----DIGLRIRSILMG 319

  Fly   175 MIYRKALR--LSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITY--LMYREI 235
            .|||..|.  ::..|..||        :::|.......:.:::.:|..|:.| :||:  |....:
Mosquito   320 AIYRSILHDGITSNASSDT--------LTSDTALFVPFIQNLHMMWSAPLII-LITFVALWVGVL 375

  Fly   236 GISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKM 300
            |.....|:|:::..|.:...|.||.:.........:::|||:....|..:|.||....|..|.:.
Mosquito   376 GPIGTVGLAIIVAVIAITRKLAKKIAAQEKHITAHSNDRVRLTTASIEQMQQIKSDLMEPFFEQR 440

  Fly   301 INYVRTKEMNAIRNVNYIRGTLQSFIMFVTRIS----------VFVSLVGFVLLGKLLTAEKAFV 355
            |...|..|::.:  ..||   |...:.::..|:          :|:.:||   .|.|||.:..||
Mosquito   441 IGEHRRAELSHM--CTYI---LYDALKYLLSIATPMIVACGTFLFMYVVG---SGALLTVQSMFV 497

  Fly   356 ITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIA-- 418
            ..|.:.:.|..:: ..|..::.:..:.|.::.|...:...:.:........:....|.||..:
Mosquito   498 AIALFGLTRYPLS-ELPNLMANWGTINVKLQVINEVVCSGKQRKSSGKMPQNGSSTGGAGRGSFE 561

  Fly   419 --EPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWD-QKNTDNTLDNISLKFKPRQLVAVIGPV 480
              :..|......|:.|...||.||   |:...:||:. :|||  .|..|:|..:....:.|.|..
Mosquito   562 KMQEVVHTFVDQLEDSIADTSRAE---VLRIERAKFSTEKNT--ILRGINLTLREGTFIGVSGTH 621

  Fly   481 GSGKSSLIQAVLGELNPDSGSVKVN-GTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRC 544
            ||||:||::|::|.|....|:..:. ..::|..|.||:.:||:|.|||||...:|.||..|::.|
Mosquito   622 GSGKTSLLRAMIGRLQRTGGTSTIAWNRVAYCPQTPWIHSGTIRSNILFGQEYEKSRYEEVLRAC 686

  Fly   545 ALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFD- 608
            .||.|.:..|..|:.:|.|.|.||||||..|:||||||||.||:|||||||.::|.:|.|.:|:
Mosquito   687 CLEEDLKTFPDYDERVVSEGGHSLSGGQARRVSLARAVYRHADVYLLDDPLRSLDPNVARKVFEG 751

  Fly   609 --QCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKD 671
              ....|.|.....:.::|..:.|..||.:::|      |.||.|.:.|.    |::..:...:.
Mosquito   752 VFHRQHGLLAGCTCVFISHDPEHLSIADKVLVM------AGGTIEKVLKP----AEVSVELLGQL 806

  Fly   672 EGAGDAP---DKKSLSRQNSKLRDRHGSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYF 733
            .||.|.|   :|...:.|.:|.|.|..               .|..|..|  ||.:.:
Mosquito   807 NGAEDEPEQEEKAPKADQQNKKRARKA---------------QPKGTDHG--EGNVSL------- 847

  Fly   734 GANGYGLFIVFA-----FFCIGA---QVLASGGDI----FLSYWVNKNGEAERDTFMARLRRAFP 786
                 ||::.||     .:|:||   :...:..||    .|:.|    ..:::.|..|.|
Mosquito   848 -----GLYVTFARMLKRRYCVGALCFESTVTALDIVIITLLAQW----AASDKQTSGALL----- 898

  Fly   787 ETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNP 851
                          :.|.|....::...:::.:..:..:..|..:|:.|...:.|..|.||:.|.
Mosquito   899 --------------HTTWILCVWVLLIFLKTAIIHWAGLSLSKRVHSQMLATILRQPMEFFDLND 949

  Fly   852 SGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCI-----INVWYILATVFLVIVFYL 911
            ||.|:||||.||..||:.:.:.:..|:....:::|.:::...     :.::.:..|..|::|..|
Mosquito   950 SGVIVNRFSNDLKVVDKTIITSVRSVLSASFSVLGTLMLFVYKLHSKLLLFVLAFTAALMLVCGL 1014

  Fly   912 LRV--FYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYM 974
            .|:  ::|..:|.:||.||.:||||....:.::.|:.||:|:.|:..|:.:|....|.|.:..|.
Mosquito  1015 KRLLSYHLQVARTLKRFEASSRSPIILQYNETIQGIDTIKAYEAEDRLLRQFFERVDTHQNYIYH 1079

  Fly   975 FLATSRAFGYWLD---CVCVVYIAVITLS-----FFLFSPENGGDVGLAITQAMGMTGMVQWGMR 1031
            ....:|..|..|:   .:.:.|:|::|:|     .|.|       ||:.::..:.:...:...:.
Mosquito  1080 NRFANRWIGIRLEFIGAIVIYYVALLTVSNQSMVGFAF-------VGIIVSYVLRLIPSLNSLLL 1137

  Fly  1032 QSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPED--------GKIVFDDLSLKYFPD 1088
            ....||..:.:.|||.:|.||:.|      .|.....|:|..        |.|::.|.||.:
Mosquito  1138 ALGALEENIISFERVAQYLDLQRE------TNDDTGVDYPTSGMDKHPVLGPIIYRDFSLTH--- 1193

  Fly  1089 KAAD--YVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRL--SYNEGAILIDRRDTNDLGLHD 1149
              ||  .||.::.:.|...||:|||||||:||||.|..|||.  .:..|.|.|...:...:.|..
Mosquito  1194 --ADGSTVLHNVTLTIAAGEKLGIVGRTGSGKSSFIGTLFRFYPKHTTGYISIAHVELGRISLQK 1256

  Fly  1150 LRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNF 1214
            ||.:::::||...||||.::..:||.:.::|.:|...|.|..|..|  .|.:.|:        |.
Mosquito  1257 LRGELTLVPQSTSLFSGVVQNFIDPRNGHTDEELIRCLRECGLGNV--HLATPLE--------NL 1311

  Fly  1215 SVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSD 1279
            ||||.||:||.|..||:..|:::||||:.:|..|:.||...:..:|...|||.|||.|:|:.:..
Mosquito  1312 SVGQCQLLCLVRGFLRKKPIIILDEATSALDEATEDLILKVLDKQFHGRTVLMIAHHLNTLRNCH 1376

  Fly  1280 KVLVMDAGKAVEFGSPFELLTTSEK 1304
            :||.:..|:..:. :|.:..|..|:
Mosquito  1377 RVLWLQEGRVRKI-APLQDYTVEER 1400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	364/1375 (26%)
		ABC_membrane	98..367	CDD:294371	61/283 (22%)
		ABCC_MRP_domain1	443..643	CDD:213217	81/204 (40%)
		ABC_membrane	799..1027	CDD:294371	59/242 (24%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	82/224 (37%)
AgaP_AGAP008436	XP_317007.3	ABC_membrane	283..509	CDD:294371	57/263 (22%)
		ABCC_MRP_domain1	587..788	CDD:213217	81/208 (39%)
		LolD	597..792	CDD:224059	82/202 (41%)
		MdlB	853..1389	CDD:224055	165/586 (28%)
		ABC_membrane	908..1120	CDD:294371	56/218 (26%)
		P-loop_NTPase	1182..1386	CDD:304359	82/218 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920