DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and AgaP_AGAP006427

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_316463.3	Gene:	AgaP_AGAP006427 / 1277037	VectorBaseID:	AGAP006427	Length:	1389	Species:	Anopheles gambiae

Alignment Length:	1389	Identity:	829/1389 - (59%)
Similarity:	1047/1389 - (75%)	Gaps:	77/1389 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSMKADELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAW 65
            |::.|..|....||:|:|..|.::|.:.:|.||||.||.|:.:|||:.|:||:||.||.:|..||
Mosquito     1 MEAQKRKEREPCPRQKANFLSYIIFGWTIPIFFKGYKKELNTDDLYQPLREHKSDGLGDRLCEAW 65

  Fly    66 EKEVEKKRKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEG 130
            |.|.::.|.|.:.|.||:|...||||.:|.|||||..||:.|:|:||.|||.|||||   |.|:|
Mosquito    66 ENEQKQARMKNRKPKLLRAGFRVFGWEIALLGLVLLTLEMLFKVSQPFFLGKLVAYY---SRQQG 127

  Fly   131 DNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQ 195
            | .|:|||||..|:|.||.||||:|||||...|:|||.|:|..||||||:||||:|||||||.||
Mosquito   128 D-ITEAYLYAGAVVLCSAINVLFIHPYMLSQLHLGMKLRVAACSMIYRKSLRLSKTALGDTTAGQ 191

  Fly   196 VVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKT 260
            ||||:||||||||::|:.::|||:||:|..::|||||||||.||.:||..:||||||||||||||
Mosquito   192 VVNLLSNDVGRLDLAVLFVHYLWIGPLETLVVTYLMYREIGYSAIYGVLFLLLFIPLQAYLGKKT 256

  Fly   261 SVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSF 325
            |.|||:||||||||||:|||||.||||||||.||.||:.::...|.||:..||.|:||||.|.||
Mosquito   257 SELRLRTALRTDERVRLMNEIIQGIQVIKMYTWERPFAALVAMARKKEIKVIRYVSYIRGILLSF 321

  Fly   326 IMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQT 390
            |||.||:|:|:|||.:.|.|:::||||||.|||||||||.|||::||.||.||||.|||:||||.
Mosquito   322 IMFTTRVSIFLSLVAYALAGQVVTAEKAFAITAYYNILRTTMTIFFPQGIGQFAEALVSVRRIQK 386

  Fly   391 FMLHEETKVR--DKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPS--SRRTSEAEH-----SIVIS 446
            ||.::|.:..  :|..|.|...|..:..|..   :::.|:.:|:  :....:.:|     .:::.
Mosquito   387 FMQYDEIESAEGEKKPDADPLALPNSKFIRH---SESDGLKEPAAVNNHHHQQQHHLSDAGVIVE 448

  Fly   447 KLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYA 511
            |..|:||.|.|:.|||.:.|..:|..|||||||||:||||||.|:||||..:|||:||||.:|||
Mosquito   449 KAVARWDAKATELTLDGVDLHVQPGTLVAVIGPVGAGKSSLIHAILGELPLESGSIKVNGNVSYA 513

  Fly   512 SQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARI 576
            |||||||:||||||||||||||:.||:.|||.|||||||.|....|||||||||.||||||||||
Mosquito   514 SQEPWLFSGTVRQNILFGLPMDRERYKQVVKTCALERDFHLFADGDKTIVGERGVSLSGGQKARI 578

  Fly   577 SLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDK 641
            ||||||||:|::|||||||||||:||||||||.|||.:||.:||:|||||||:|:.||.||:|..
Mosquito   579 SLARAVYRRAEVYLLDDPLSAVDSHVGRHLFDHCMRDYLRGKIVILVTHQLQYLQNADQIVVMMH 643

  Fly   642 GKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAAES 706
            |::.|:|||:.:.:||.||||:|..||.:::   |:.|.:|:.|..| |..|..|.|||:||...
Mosquito   644 GRVEAVGTYDKLRESGQDFAQLLAAPSGRED---DSTDTESIKRSGS-LYKRQNSESSMDSAVAD 704

  Fly   707 LAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFC-IGAQVLASGGDIFLSYWVNK-- 768
            ........|:|.:.||.||..:|:.||.|:|..|.:|...|. :.:|:.|||||.||:|||||
Mosquito   705 GEGPEAKATEERQKEGSIGYDVYRAYFRASGGNLVVVLILFMFLLSQLSASGGDYFLTYWVNKAE 769

  Fly   769 ----------------------NGEAER-----------------------DTFMARLRRAFPET 788
                                  |..||.                       ..|...:|:.|
Mosquito   770 EKAPAATGGDGGAAGAMFSALANASAEEFNETTTFEPPAVTTAVTTGAGGIGVFFTAIRQMF--- 831

  Fly   789 RINADTDP---VDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTN 850
             .:.|.:.   :|||.||.:.|:.::.:|.|||.||..||::|..||:.||.|:|||:|:|||||
Mosquito   832 -ASGDEEEDRYIDIYIFTALTVATVVITLTRSMFFFRTAMKASRKLHDAMFNGITRASMYFFNTN 895

  Fly   851 PSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVF 915
            ||||||||||||:||:||.||||.:||:||||:::|||||:.|:|.:.::.||.:.|:||.:|.|
Mosquito   896 PSGRILNRFSKDMGQIDEYLPSVTVDVIQIFLSLIGIVVVVAIVNPYNLIPTVVIGIIFYFMRAF 960

  Fly   916 YLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSR 980
            ||.|||::||:||:|||||||||||||:||:|||||||:|.|:.|||::||:|||.:|:|::|||
Mosquito   961 YLLTSRNIKRVEAITRSPIYSHLSASLSGLSTIRAFGAEKVLVHEFDSHQDLHSSAFYLFISTSR 1025

  Fly   981 AFGYWLDCVCVVYIAVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVER 1045
            |||::||..||:|||::||:||: ..::||:||||||||:|||||||||||||||||||||:|||
Mosquito  1026 AFGFYLDVFCVIYIAIVTLTFFI-RGDSGGNVGLAITQALGMTGMVQWGMRQSAELENTMTSVER 1089

  Fly  1046 VVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGI 1110
            ||||::::||...|:..:|||||:||::|:|.|:.::|:|.||..:|.|||.|...||..||:||
Mosquito  1090 VVEYDNVDPEPALEAPADKKPPKEWPQEGRIRFEKVTLRYSPDADSDLVLRDLQFEIEPREKIGI 1154

  Fly  1111 VGRTGAGKSSLINALFRLSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPF 1175
            |||||||||||||||||||||.|:||||.|||:.:||||||:|:|||||||||||||:|||||||
Mosquito  1155 VGRTGAGKSSLINALFRLSYNGGSILIDTRDTSQMGLHDLRAKLSIIPQEPVLFSGTLRYNLDPF 1219

  Fly  1176 DEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEA 1240
            |||.|.|||.:|:||||:..|.:|||||.|||:|||:||||||||||||||||||||:|||||||
Mosquito  1220 DEYPDEKLWRALKEVKLEDAVNELPSGLSSKINEGGSNFSVGQRQLVCLARAILRENKILVMDEA 1284

  Fly  1241 TANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTT-SEK 1304
            |||||||||.|||.|||.||.|||||||||||:||||||||||||||:.||||:|:||||| ...
Mosquito  1285 TANVDPQTDKLIQQTIREKFNDCTVLTIAHRLNTVMDSDKVLVMDAGRCVEFGTPYELLTTEGGP 1349

  Fly  1305 KVFHSMVKQTGDSTFDALLKVAQK 1328
            |||:.||||||.|||:.|||:|::
Mosquito  1350 KVFYGMVKQTGKSTFNTLLKIAEE 1373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	807/1347 (60%)
		ABC_membrane	98..367	CDD:294371	182/268 (68%)
		ABCC_MRP_domain1	443..643	CDD:213217	142/199 (71%)
		ABC_membrane	799..1027	CDD:294371	143/227 (63%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	171/220 (78%)
AgaP_AGAP006427	XP_316463.3	CFTR_protein	13..1344	CDD:273530	807/1346 (60%)
		ABC_membrane	106..363	CDD:294371	177/260 (68%)
		ABCC_MRP_domain1	445..645	CDD:213217	142/199 (71%)
		ABC_membrane	844..1068	CDD:294371	140/224 (63%)
		ABCC_MRP_domain2	1118..1339	CDD:213211	171/220 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	310	1.000	Domainoid score	I3486
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1688	1.000	Inparanoid score	I247
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm50195
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X771
TreeFam	0	0.000	Not matched by this tool.
	11	11.080