DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and AgaP_AGAP005639

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_315658.3	Gene:	AgaP_AGAP005639 / 1276325	VectorBaseID:	AGAP005639	Length:	1301	Species:	Anopheles gambiae

Alignment Length:	1305	Identity:	298/1305 - (22%)
Similarity:	527/1305 - (40%)	Gaps:	247/1305 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIY 177
            :|.||.|...|............|..:.|||:..:....:|. ...:.:.:...:.:|:....::
Mosquito   116 IFGGGRVLVNATEQENAAAIMEDAKAFGLGVVAVTILQFIFA-TLSVDVINRSAQKQISRIRQLF 179

  Fly   178 RKA-LRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYR---EIGIS 238
            .|| ||...|.....:.......|::|:.:|...:         ..::.|.|||:..   .:..|
Mosquito   180 LKAVLRQDMTWYDLNSDDSFAVRITDDLDKLKEGI---------GEKLSIFTYLVMSFVISVIFS 235

  Fly   239 AFFG---VAVMLLFIPL----QAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIP 296
            .|:|   ..|:|...|:    .|::.|..|.|..|..........:..|::..|:.:..:..|
Mosquito   236 FFYGWKLTLVILSCAPIIILATAFVAKMQSTLTEKELKSYSSAGAVAEEVLGSIRTVVAFGGE-- 298

  Fly   297 FSKMINYVRTK----EMNAIRN--VNYIRGTLQSFIMFVTRISVFVSLVGFVLLGK---LLTAEK 352
             .|..:..|.:    |:|..|.  .:.|.|.:..||::......|...:..:|..:   |.....
Mosquito   299 -KKEADRYRERLAGAELNGRRKGLFSGIGGGIMWFIIYCCYALAFWYGISLILEDRDKDLKDYTP 362

  Fly   353 AFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEET-----KVRDKSEDLDEQKLG 412
            |.:|...:.:|.....    :|:|.        ..::.|...:.:     .|.|:...:|  .||
Mosquito   363 AVLIIVLFGVLAGAQN----LGLSS--------PHLEAFSTAKGSAATIFSVIDRIPVID--SLG 413

  Fly   413 KAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVI 477
            .|||                  |....:.:|..|.:..::..:|....|..::|:.|..|.||::
Mosquito   414 DAGL------------------RPGSMQGNIKFSNVFFRYPARNDVQVLQGLNLEIKTGQTVALV 460

  Fly   478 GPVGSGKSSLIQAVLGELNPDSGSVKVNGT-------------LSYASQEPWLFTGTVRQNILFG 529
            ||.|.|||:.:|.:....:|.||||.::||             :....|||.||..|:.:||.:|
Mosquito   461 GPSGCGKSTCLQLIQRLYDPLSGSVTIDGTKVSELNIGWLRSFIGLVGQEPVLFATTIAENIRYG 525

  Fly   530 LPMDKHRYRTVVKRCALERDFEL---------LPYADKTIVGERGASLSGGQKARISLARAVYRK 585
            .|        ...:..:||..::         ||....|::|||||.||||||.||::|||:.|.
Mosquito   526 NP--------DASQSEIERAAKIANCHSFITKLPNGYATMIGERGAQLSGGQKQRIAIARALVRN 582

  Fly   586 ADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTY 650
            ..|.|||:..||:|.:..:.:.|...|. .:....|:|:|:|..:..||.||.:|||.:...||:
Mosquito   583 PKILLLDEATSALDPNSEKRVQDALERA-SKGRTTLVVSHRLSTITNADKIVYIDKGLVMEQGTH 646

  Fly   651 ES-MAKSGLDFAQMLTDPSKK----DEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAAESLAAE 710
            |. ||..||.:..::...|:|    ||....||  .:||.:...:.|  |:.:|.:.:....:.|
Mosquito   647 EELMAARGLYYDLVVASGSQKTVDDDESVPMAP--SALSMRQESVDD--GAEASDDESDSGKSDE 707

  Fly   711 SPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASG---GDIFLSYWVNKNGEA 772
            ...:.||......: |:|.|.......|.||...|...:||...|..   |:::
Mosquito   708 KNEEEQEEVYHVSL-MRLLKLNAPEWHYILFGCAAAIVVGASFPAFAVLFGEMY----------- 760

  Fly   773 ERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVI--IFSLVRSMLFFYLAMRSSTTLHNTM 835
                  ..|..|.|| .:..::   :.|.|..:.:.:|  :.:..::.||....:|.::.|....
Mosquito   761 ------GILSVADPE-YVKEES---NFYSFLFLVLGLITGVGTFFQTYLFNIAGVRLTSRLRQKS 815

  Fly   836 FQGVTRAAMHFF--NTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAI---VGI-------V 888
            |:.:....|.:|  :.|..|.:..|.|.|...|.....:.:..::|....|   |||       :
Mosquito   816 FKAIVSQDMAWFDESRNAVGALCARLSGDCASVQGATGTRIGSLLQAASTICIGVGISFFYSWNL 880

  Fly   889 VVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGA 953
            .::.||.:...||::.|.     .|....|:.::.:..|..|:..:     .:::.:.|:.:.|.
Mosquito   881 TLVSIIAIPVTLASITLE-----SRYSQTSSLKEKQSQEGATKLAV-----EAISNIRTVASLGQ 935

  Fly   954 QKELIAEFDNY----------------------QDMHSSGYYMFL-------------------- 976
            :|.::..:...                      |.|..:||.:.|
Mosquito   936 EKHVLQRYGEETVKIDDACRRKTRLRGTVFALGQVMPFAGYGLALFYGGKLVSEKELEYKDVIKV 1000

  Fly   977 ATSRAFGYWLDCVCVVYIAVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMT 1041
            :.:..||.|:                         :|.|:..|..:...:....|....|:.|..
Mosquito  1001 SEALIFGAWM-------------------------LGQALAYAPNVNSAILSAGRLMKLLDRTPR 1040

  Fly  1042 AVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCE 1106
            .......|..|...                .:|.|.|.|:..:| |.:....||:.||:.|...:
Mosquito  1041 MHNPSTSYHSLSQR----------------TEGDIKFTDVEFRY-PTRPTVPVLQGLNLDIGKGQ 1088

  Fly  1107 KVGIVGRTGAGKSSLINALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRY 1170
            .|.:||.:|.|||:.|..|.| ...:.|.:.||...|.:..|:.:|:::.::.|||:||..|:..
Mosquito  1089 TVALVGPSGCGKSTCIQLLLRYYDPDSGKVDIDGTTTTEFSLNRIRAQMGLVSQEPILFDRTIAE 1153

  Fly  1171 NLDPFDEYSDAKLWESLEEVKLKQV---VADLPSGLQSKISEGGTNFSVGQRQLVCLARAILREN 1232
            |:...|...:..:.|.:|..|:..:   :.:||.|..:.:...|...|.||:|.:.:|||::|..
Mosquito  1154 NIAYGDNTREIAMPEIMEAAKMANIHEFIVNLPKGYDTSLGSKGAQLSGGQKQRIAIARALVRNP 1218

  Fly  1233 RILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFE 1297
            |:|::||||:.:|.|::.::|..:.:.....|.:.|||||.|:.:::.:.|:..|..||.|:..|
Mosquito  1219 RVLLLDEATSALDNQSEKIVQNALDHARTGRTCIIIAHRLTTIQNANLICVIQNGVVVEAGTHDE 1283

  Fly  1298 LLTTS 1302
            |:..|
Mosquito  1284 LMAKS 1288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	297/1301 (23%)
		ABC_membrane	98..367	CDD:294371	52/273 (19%)
		ABCC_MRP_domain1	443..643	CDD:213217	74/221 (33%)
		ABC_membrane	799..1027	CDD:294371	44/283 (16%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	71/224 (32%)
AgaP_AGAP005639	XP_315658.3	PTZ00265	114..1299	CDD:240339	298/1305 (23%)
		ABC_membrane	137..376	CDD:279056	47/251 (19%)
		ABC_MTABC3_MDL1_MDL2	426..662	CDD:213216	82/244 (34%)
		ABC_membrane	741..1009	CDD:279056	49/298 (16%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	73/231 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910