DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCC2

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_000383.2	Gene:	ABCC2 / 1244	HGNCID:	53	Length:	1545	Species:	Homo sapiens

Alignment Length:	1433	Identity:	498/1433 - (34%)
Similarity:	769/1433 - (53%)	Gaps:	208/1433 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKE--- 68
            :|...||...::..||:.:.:......||.|:.|...|::...:|.::..|.||.....::|
Human   188 NESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQK 252

  Fly    69 ---------------------------------------VEKKRKKKKTPS------LLKASMNV 88
                                                   ||||:||..|..      |:||....
Human   253 ARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKT 317

  Fly    89 FGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLF 153
            |...|....|:..:.:| |....|..|..|:::.:|...........|.|.....::.|.|
Human   318 FYMVLLKSFLLKLVNDI-FTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFC---- 377

  Fly   154 MHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRL-DV-SVIHMNY 216
            :..|....|.:|:|.|.|:.:.:|:|||.||..|..:.|:|:.|||:|.|..:| || :.:||
Human   378 LQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHM-- 440

  Fly   217 LWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEI 281
            ||...::|.:..:.::||:|.|...||.||:|.||:.|.|..|:..:::|.....|:|:::||||
Human   441 LWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEI 505

  Fly   282 ISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRIS-VFVSLVGF---V 342
            :|||:::|.:|||..|...:..:|.||:..:...:    .||..::||.::: |.||:|.|   |
Human   506 LSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFS----QLQCVVIFVFQLTPVLVSVVTFSVYV 566

  Fly   343 LL--GKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSED 405
            |:  ..:|.|:|||.....:||||..::: .||.||...:..||..|::.::         ..:|
Human   567 LVDSNNILDAQKAFTSITLFNILRFPLSM-LPMMISSMLQASVSTERLEKYL---------GGDD 621

  Fly   406 LDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKP 470
            ||...:                      |.....:.::..|:....|:. :::.|:.:::|....
Human   622 LDTSAI----------------------RHDCNFDKAMQFSEASFTWEH-DSEATVRDVNLDIMA 663

  Fly   471 RQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKH 535
            .|||||||||||||||||.|:|||:....|.:.:.||.:|..|:.|:..||::.|||||...::.
Human   664 GQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEK 728

  Fly   536 RYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDT 600
            ||:.|::.|||..|.|:||..|...:||:|.:||||||.|||||||.|:..|||||||||||||.
Human   729 RYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDA 793

  Fly   601 HVGRHLFDQCM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYES-MAKSGLDFAQ 662
            |||:|:|::.:  .|.|:.:..|||||.:.||.|.|.||::..|.|...|:|.: :||.| :||:
Human   794 HVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKG-EFAK 857

  Fly   663 ML------TDPSKK---DEGAGDAPD--------------------------KKSLSRQNSKLRD 692
            .|      |.|.::   .:|:.:..|                          :::||| :|:...
Human   858 NLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSR-SSRSNG 921

  Fly   693 RHGSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANG-------------YGLFIVF 744
            ||  :.|:.::.::....| ::..|..|:|:   ||.||.|...|             .|||.:
Human   922 RH--LKSLRNSLKTRNVNS-LKEDEELVKGQ---KLIKKEFIETGKVKFSIYLEYLQAIGLFSI- 979

  Fly   745 AFFCIGAQVLAS----GGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTD--------PV 797
             ||.|.|.|:.|    |.:::||.|.:                   :::|...||        .|
Human   980 -FFIILAFVMNSVAFIGSNLWLSAWTS-------------------DSKIFNSTDYPASQRDMRV 1024

  Fly   798 DIYYFTGINVSVIIFSLVRSMLFFYLA---MRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRF 859
            .:|...|:...:.:|     :..|:.|   :.:|..||..:...:.||.|.||:|.|:|||:|||
Human  1025 GVYGALGLAQGIFVF-----IAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRF 1084

  Fly   860 SKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVK 924
            :.|:..||:.||..:...:..||.|:..:|::|:....:.:..:.|.|::..:::||:||||.::
Human  1085 AGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLR 1149

  Fly   925 RLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCV 989
            ||::|||||||||.|.:::||..||||..|:..:...:...|.:....:.::.::|.....|:.|
Human  1150 RLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELV 1214

  Fly   990 CVVYIAVITLSFFLFSPENGGD-VGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLE 1053
            ..:.:....|...::.....|| ||..::.|:.:|..:.|.:|.::|:|..:.||||:.||..:|
Human  1215 GNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVE 1279

  Fly  1054 PEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGK 1118
            .|..:.:  :|:||.|||..|||.|::..::|.|:  .|.|||.:...|...||:|:||||||||
Human  1280 NEAPWVT--DKRPPPDWPSKGKIQFNNYQVRYRPE--LDLVLRGITCDIGSMEKIGVVGRTGAGK 1340

  Fly  1119 SSLINALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAK 1182
            |||.|.||| |....|.|:||..|...:||||||.|::||||:|:||||::|.|||||:.|||.:
Human  1341 SSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEE 1405

  Fly  1183 LWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQ 1247
            :|::||...||..||.|..||..:::|.|.|.|:|||||:||.||:||:::|||:|||||.||.:
Human  1406 IWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLE 1470

  Fly  1248 TDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVK 1312
            ||.||||||:|:|..|||:||||||||:||||||:|:|.||.:|.|||.|||.....  |:.|.|
Human  1471 TDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGP--FYFMAK 1533

  Fly  1313 QTG 1315
            :.|
Human  1534 EAG 1536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	492/1411 (35%)
		ABC_membrane	98..367	CDD:294371	91/276 (33%)
		ABCC_MRP_domain1	443..643	CDD:213217	97/201 (48%)
		ABC_membrane	799..1027	CDD:294371	69/231 (30%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	128/221 (58%)
ABCC2	NP_000383.2	SunT	8..1537	CDD:331423	498/1433 (35%)
ABCC2	NP_000383.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..284		0/30 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151612
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.760