DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and Abcc5

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_446376.1	Gene:	Abcc5 / 116721	RGDID:	70913	Length:	1436	Species:	Rattus norvegicus

Alignment Length:	1384	Identity:	465/1384 - (33%)
Similarity:	748/1384 - (54%)	Gaps:	141/1384 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ENPREKSNIFSSLMFCFAMPTFFKGRKK-TLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRK 74
            ::|.:.:.:||.:.|.:..|......|| .|...|::...:...||....:|...|::|:.:...
  Rat    98 QHPVDNAGLFSYMTFSWLSPLAQVVHKKGELLMEDVWPLSKYESSDVNCRRLERLWQEELNEVGP 162

  Fly    75 KKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQ------PLFLGGLVAYYADASNQEGDNQ 133
            .       .||:....|......|:|.|  :...:||      |.|:...:..|..|:.   .|.
  Rat   163 D-------AASLRRVVWIFCRTRLILSI--VCLMITQLAGFSGPAFVVKHLLEYTQATE---SNL 215

  Fly   134 TKAYLYALGVILTSACNVLFMHPYMLGM-----FHIGMKARIAMTSMIYRKALRLSRTALGDTTI 193
            ..:.|..||::||..     :..:.|.:     :..|::.|.|:.:|.::|.|:|..  :.:.::
  Rat   216 QYSLLLVLGLLLTEV-----VRSWSLALTWALNYRTGVRLRGAVLTMAFKKILKLKN--IKEKSL 273

  Fly   194 GQVVNLISNDVGRLDVSVIHMNYLWLGPVE--IGIITYLMYREIGISAFFGVAVMLLFIPLQAYL 256
            |:::|:.|||..|:..:....:.|..|||.  :|:|..::.  :|.:.|.|.||.:||.|...::
  Rat   274 GELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVII--LGPTGFLGSAVFILFYPAMMFV 336

  Fly   257 GKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGT 321
            .:.|:..|.|....||:||:.|||:::.|:.||||||...||:.:..:|.:|...:....|
  Rat   337 SRLTAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIREEERRILEKAGY---- 397

  Fly   322 LQSFIMFVTRISVFV-SLVGF---VLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELL 382
            .||..:.|..|.|.: |:|.|   :.||..|||.:||.:...:|.:...:.| .|..:...:|..
  Rat   398 FQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKV-TPFSVKSLSEAS 461

  Fly   383 VSIRRIQTFMLHEET---KVRDKSEDLD-EQKLGKAGLIAEPTVAQTTGVLKP------------ 431
            |::.|.::..|.||.   |.:..|..:. |.|.......:..:..|::..|.|
  Rat   462 VAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSTQSSPKLTPKVKKDKRAPKGK 526

  Fly   432 --SSRRTSEAEHSIVISKLKAKW----DQK----------------NTDNTLDNISLKFKPRQLV 474
              .||:....||..|:::.|...    |::                ....||.||.|:.:..:||
  Rat   527 KEKSRQLQHTEHQAVLAEQKGHLLLDSDERPSPEEEEGKQIHAGSMRLQRTLYNIDLEIEEGKLV 591

  Fly   475 AVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRT 539
            .:.|.|||||:|||.|:||::....||:.|:||.:|.:|:.|:...|:|.|||||...|:.||.:
  Rat   592 GICGSVGSGKTSLISAILGQMTLLEGSIAVSGTFAYVAQQAWILNATLRDNILFGKEFDEERYNS 656

  Fly   540 VVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGR 604
            |:..|.|..|..:||.:|.|.:|||||:|||||:.|||||||:|....||:|||||||:|.|||.
  Rat   657 VLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGN 721

  Fly   605 HLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSK 669
            |:|:..:|..|:.:.||.||||||:|...|.::.|.:|.|:..||:|.:.....|:|.:..:..
  Rat   722 HIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLL- 785

  Fly   670 KDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAAE--SLAAESPMQTQEGRV-------EGRIG 725
                .|:.|..:.    ||| ::..||..|.:...:  |:..|..::::||::       :|.:.
  Rat   786 ----LGETPPVEI----NSK-KEASGSQKSQDKGPKPGSVKKEKAVKSEEGQLVQVEEKGQGSVP 841

  Fly   726 MKLYKKYFGANG--YGLFIVFAFFC--IGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFP 786
            ..:|..|..|.|  ....::...|.  :|:...::.   :||||: |.|......|.........
  Rat   842 WSVYWVYIQAAGGPLAFLVIMVLFMLNVGSTAFSTW---WLSYWI-KQGSGNSTVFEGNRSSVSD 902

  Fly   787 ETRINADTDPVDIYYFT--GINVSV-IIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFN 848
            ..|.|    |...||.:  .::::| :|...:|.::|....:|:|:.||:.:|:.:.|:.|.||:
  Rat   903 SMRDN----PFLQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFD 963

  Fly   849 TNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCI-----INVWYILATVFLVIV 908
            |.|:||||||||||:.:||..||.    ..::|:..| |:|..|:     :..|:::|...|:|:
  Rat   964 TTPTGRILNRFSKDMDEVDVRLPF----QAEMFIQNV-ILVFFCVGMIAGVFPWFLVAVGPLLIL 1023

  Fly   909 FYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYY 973
            |.:|.:......|::|||:.:|:||..||:::|:.|||||.|:..::|.:..:....|.:.:.::
  Rat  1024 FSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFF 1088

  Fly   974 MFLATSRAFGYWLDCVCVVYIAVITLSFFLFSPENGGDV-----GLAITQAMGMTGMVQWGMRQS 1033
            :|....|.....||.:.:..|....|...|..    |.:     ||||:.|:.:||:.|:.:|.:
  Rat  1089 LFTCAMRWLAVRLDLISIALITTTGLMIVLMH----GQIPSAYAGLAISYAVQLTGLFQFTVRLA 1149

  Fly  1034 AELENTMTAVERVVEY-EDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRS 1097
            :|.|...|:|||:..| :.|..|.....| ||.||.|||::|:|.|::..::|  .:....||:.
  Rat  1150 SETEARFTSVERINHYIKTLSLEAPARIK-NKAPPHDWPQEGEITFENAEMRY--RENLPLVLKK 1211

  Fly  1098 LNIAIEGCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEP 1161
            ::..|:..||:|||||||:|||||..||||| ..:.|.|.||....:|:||.|||||::||||||
  Rat  1212 VSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLTIIPQEP 1276

  Fly  1162 VLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLAR 1226
            ||||||:|.|||||::|::.::|::||...:|:.:|.||..|:|::.|.|.|||||:|||:|:||
  Rat  1277 VLFSGTVRSNLDPFNQYTEEQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIAR 1341

  Fly  1227 AILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVE 1291
            |:||..:||::|||||.:|.:||.|||.|||..|.|||:||||||||||:.||:::|:..|:.||
  Rat  1342 ALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVE 1406

  Fly  1292 FGSPFELLTTSEKKVFHSM 1310
            |.:|..||:....: |::|
  Rat  1407 FDTPSVLLSNDSSR-FYAM 1424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	462/1371 (34%)
		ABC_membrane	98..367	CDD:294371	81/285 (28%)
		ABCC_MRP_domain1	443..643	CDD:213217	94/219 (43%)
		ABC_membrane	799..1027	CDD:294371	75/240 (31%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	119/221 (54%)
Abcc5	NP_446376.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..38
		PLN03130	100..1424	CDD:215595	464/1380 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..569		10/69 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	795..822		8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345032
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660