Protein Alignment Mrp5 and ABCC4

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_005836.2
• Gene: ABCC4 / 10257
• HGNCID: 55
• Length: 1325
• Species: Homo sapiens
• Alignment Length: 1351
• Identity: 607/1351 - (44%)
• Similarity: 865/1351 - (64%)
• Gaps: 95/1351 - (7%)

  Fly     8 ELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKK 72
            |:..||.:.:|:.|.:.|.:..|.|..|.|:.|:|:|:|..|.|.||.|||.:|...|:|||.:.
Human     7 EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRA 71

  Fly    73 RKKKKTPSLLKASMNVFGWRLAGLGLVLF-ILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKA 136
            ....:.|||.:|.:..: |: :.|.|.:| ::|...:|.||:|||.::.|:.:....:......|
Human    72 ENDAQKPSLTRAIIKCY-WK-SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTA 134

  Fly   137 YLYALGVILTSACNVLFMHPYMLGMFHI---GMKARIAMTSMIYRKALRLSRTALGDTTIGQVVN 198
            |.||  .:|| .|.::....:.|..:|:   ||:.|:||..||||||||||..|:|.||.||:||
Human   135 YAYA--TVLT-FCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVN 196

  Fly   199 LISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVL 263
            |:||||.:.|...:.:::||.||::...:|.|::.|||||...|:||:::.:|||:..||..|.|
Human   197 LLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261

  Fly   264 RLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRG-TLQSFIM 327
            |.|||..||.|:|.|||:|:||::|||||||..||.:|..:|.||::.|...:.:|| .|.||..
Human   262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFS 326

  Fly   328 FVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFM 392
             .::|.|||:...:||||.::||.:.||....|..:|.|:|::||..|.:.:|.:|||||||||:
Human   327 -ASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFL 390

  Fly   393 LHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNT 457
            |.:|...|::....|.:|:                               :.:....|.||:.:.
Human   391 LLDEISQRNRQLPSDGKKM-------------------------------VHVQDFTAFWDKASE 424

  Fly   458 DNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTV 522
            ..||..:|...:|.:|:||:||||:|||||:.||||||.|..|.|.|:|.::|.||:||:|:||:
Human   425 TPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTL 489

  Fly   523 RQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKAD 587
            |.|||||...:|.||..|:|.|||::|.:||...|.|::|:||.:||||||||::||||||:.||
Human   490 RSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDAD 554

  Fly   588 IYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYES 652
            ||||||||||||..|.||||:.|:...|.|:|.:|||||||:|:.|..|:|:..||:...|||..
Human   555 IYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTE 619

  Fly   653 MAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDR---HGSISSMESAAESL---AAES 711
            ..|||:||..:|    |||....:.|....    ...||:|   ..|:.|.:|:..||   |.||
Human   620 FLKSGIDFGSLL----KKDNEESEQPPVPG----TPTLRNRTFSESSVWSQQSSRPSLKDGALES 676

  Fly   712 ------PMQ-TQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCI---GAQVLASGGDIFLSYWV 766
                  |:. ::|.|.||::|.:.||.||.|..:  :|||.|..:   .|||.....|.:||||.
Human   677 QDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAH--WIVFIFLILLNTAAQVAYVLQDWWLSYWA 739

  Fly   767 NKNGEAERDTFMARLRRAFPETRINAD---TDPVDIYY----FTGINVSVIIFSLVRSMLFFYLA 824
            ||              ::.....:|..   |:.:|:.:    ::|:.|:.::|.:.||:|.||:.
Human   740 NK--------------QSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVL 790

  Fly   825 MRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVV 889
            :.||.||||.||:.:.:|.:.||:.||.||||||||||:|.:|::||...:|.:|..|.:||:|.
Human   791 VNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVS 855

  Fly   890 VLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQ 954
            |...:..|..:..|.|.|:|..||.::|.|||||||||:.||||::||||:||.||.||||:.|:
Human   856 VAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAE 920

  Fly   955 KELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITL-SFFLFSPENGGDVGLAITQ 1018
            :.....||.:||:||..:::||.|||.|...||.:|.:::.::.. |..|....:.|.||||::.
Human   921 ERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSY 985

  Fly  1019 AMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSL 1083
            |:.:.||.||.:|||||:||.|.:||||:||.|||.|..:|.:  |:||..||.:|.|:||:::.
Human   986 ALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQ--KRPPPAWPHEGVIIFDNVNF 1048

  Fly  1084 KYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNEGAILIDRRDTNDLGLH 1148
            .|.|  ....||:.|...|:..|||||||||||||||||:||||||..||.|.||:..|.::|||
Human  1049 MYSP--GGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLH 1111

  Fly  1149 DLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTN 1213
            |||.|:||||||||||:||||.|||||:|::|.:||.:|:||:||:.:.|||..:.::::|.|:|
Human  1112 DLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSN 1176

  Fly  1214 FSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDS 1278
            |||||||||||||||||:|:||::|||||||||:||.|||..||.||..||||||||||:|::||
Human  1177 FSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDS 1241

  Fly  1279 DKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTGDSTFDALLKVAQKV 1329
            ||::|:|:|:..|:..|:.||...| .:|:.||:|.|.:...||.:.|::|
Human  1242 DKIMVLDSGRLKEYDEPYVLLQNKE-SLFYKMVQQLGKAEAAALTETAKQV 1291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	576/1264 (46%)
ABCC4	NP_005836.2	PLN03130	12..1277	CDD:215595	600/1330 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	657..688		9/30 (30%)
		PDZ-binding	1322..1325