DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCC4

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_005836.2	Gene:	ABCC4 / 10257	HGNCID:	55	Length:	1325	Species:	Homo sapiens

Alignment Length:	1351	Identity:	607/1351 - (44%)
Similarity:	865/1351 - (64%)	Gaps:	95/1351 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKK 72
            |:..||.:.:|:.|.:.|.:..|.|..|.|:.|:|:|:|..|.|.||.|||.:|...|:|||.:.
Human     7 EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRA 71

  Fly    73 RKKKKTPSLLKASMNVFGWRLAGLGLVLF-ILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKA 136
            ....:.|||.:|.:..: |: :.|.|.:| ::|...:|.||:|||.::.|:.:....:......|
Human    72 ENDAQKPSLTRAIIKCY-WK-SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTA 134

  Fly   137 YLYALGVILTSACNVLFMHPYMLGMFHI---GMKARIAMTSMIYRKALRLSRTALGDTTIGQVVN 198
            |.||  .:|| .|.::....:.|..:|:   ||:.|:||..||||||||||..|:|.||.||:||
Human   135 YAYA--TVLT-FCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVN 196

  Fly   199 LISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVL 263
            |:||||.:.|...:.:::||.||::...:|.|::.|||||...|:||:::.:|||:..||..|.|
Human   197 LLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261

  Fly   264 RLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRG-TLQSFIM 327
            |.|||..||.|:|.|||:|:||::|||||||..||.:|..:|.||::.|...:.:|| .|.||..
Human   262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFS 326

  Fly   328 FVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFM 392
             .::|.|||:...:||||.::||.:.||....|..:|.|:|::||..|.:.:|.:|||||||||:
Human   327 -ASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFL 390

  Fly   393 LHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNT 457
            |.:|...|::....|.:|:                               :.:....|.||:.:.
Human   391 LLDEISQRNRQLPSDGKKM-------------------------------VHVQDFTAFWDKASE 424

  Fly   458 DNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTV 522
            ..||..:|...:|.:|:||:||||:|||||:.||||||.|..|.|.|:|.::|.||:||:|:||:
Human   425 TPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTL 489

  Fly   523 RQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKAD 587
            |.|||||...:|.||..|:|.|||::|.:||...|.|::|:||.:||||||||::||||||:.||
Human   490 RSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDAD 554

  Fly   588 IYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYES 652
            ||||||||||||..|.||||:.|:...|.|:|.:|||||||:|:.|..|:|:..||:...|||..
Human   555 IYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTE 619

  Fly   653 MAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDR---HGSISSMESAAESL---AAES 711
            ..|||:||..:|    |||....:.|....    ...||:|   ..|:.|.:|:..||   |.||
Human   620 FLKSGIDFGSLL----KKDNEESEQPPVPG----TPTLRNRTFSESSVWSQQSSRPSLKDGALES 676

  Fly   712 ------PMQ-TQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCI---GAQVLASGGDIFLSYWV 766
                  |:. ::|.|.||::|.:.||.||.|..:  :|||.|..:   .|||.....|.:||||.
Human   677 QDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAH--WIVFIFLILLNTAAQVAYVLQDWWLSYWA 739

  Fly   767 NKNGEAERDTFMARLRRAFPETRINAD---TDPVDIYY----FTGINVSVIIFSLVRSMLFFYLA 824
            ||              ::.....:|..   |:.:|:.:    ::|:.|:.::|.:.||:|.||:.
Human   740 NK--------------QSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVL 790

  Fly   825 MRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVV 889
            :.||.||||.||:.:.:|.:.||:.||.||||||||||:|.:|::||...:|.:|..|.:||:|.
Human   791 VNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVS 855

  Fly   890 VLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQ 954
            |...:..|..:..|.|.|:|..||.::|.|||||||||:.||||::||||:||.||.||||:.|:
Human   856 VAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAE 920

  Fly   955 KELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITL-SFFLFSPENGGDVGLAITQ 1018
            :.....||.:||:||..:::||.|||.|...||.:|.:::.::.. |..|....:.|.||||::.
Human   921 ERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSY 985

  Fly  1019 AMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSL 1083
            |:.:.||.||.:|||||:||.|.:||||:||.|||.|..:|.:  |:||..||.:|.|:||:::.
Human   986 ALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQ--KRPPPAWPHEGVIIFDNVNF 1048

  Fly  1084 KYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNEGAILIDRRDTNDLGLH 1148
            .|.|  ....||:.|...|:..|||||||||||||||||:||||||..||.|.||:..|.::|||
Human  1049 MYSP--GGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLH 1111

  Fly  1149 DLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTN 1213
            |||.|:||||||||||:||||.|||||:|::|.:||.:|:||:||:.:.|||..:.::::|.|:|
Human  1112 DLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSN 1176

  Fly  1214 FSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDS 1278
            |||||||||||||||||:|:||::|||||||||:||.|||..||.||..||||||||||:|::||
Human  1177 FSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDS 1241

  Fly  1279 DKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTGDSTFDALLKVAQKV 1329
            ||::|:|:|:..|:..|:.||...| .:|:.||:|.|.:...||.:.|::|
Human  1242 DKIMVLDSGRLKEYDEPYVLLQNKE-SLFYKMVQQLGKAEAAALTETAKQV 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	595/1316 (45%)
		ABC_membrane	98..367	CDD:294371	116/273 (42%)
		ABCC_MRP_domain1	443..643	CDD:213217	108/199 (54%)
		ABC_membrane	799..1027	CDD:294371	101/232 (44%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	137/220 (62%)
ABCC4	NP_005836.2	CFTR_protein	11..1269	CDD:273530	597/1323 (45%)
		ABC_membrane	96..365	CDD:294371	115/272 (42%)
		ABCC_MRP_domain1	410..610	CDD:213217	108/199 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..688		9/30 (30%)
		ABC_membrane	718..991	CDD:279056	112/286 (39%)
		ABCC_MRP_domain2	1039..1258	CDD:213211	137/220 (62%)
		PDZ-binding	1322..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151549
Domainoid	1	1.000	226	1.000	Domainoid score	I2519
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1102	1.000	Inparanoid score	I233
Isobase	1	0.950	-	0	Normalized mean entropy	S1354
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm40263
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5383
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.890