DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abcc9

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_031754288.1	Gene:	abcc9 / 101733439	XenbaseID:	XB-GENE-6074535	Length:	1577	Species:	Xenopus tropicalis

Alignment Length:	1430	Identity:	429/1430 - (30%)
Similarity:	715/1430 - (50%)	Gaps:	211/1430 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NIFSSLMFCFAMPTFFKGRKKTLDENDL------YRALQEHRSDHLGSKLSAAWEKEVEKKR--- 73
            |:.|...:.:..|......|:.:|...:      .|||..:.|      |..|:|:  :||:
Frog   221 NLLSKATYWWMNPLIISAHKRPIDLKTIGKLPIAMRALTNYLS------LKTAYEE--QKKKLVD 277

  Fly    74 KKKKTPSLLKASMNVFGWRLAGLGLVLFILE-IGFRVTQPLFLGGLVAYYADASNQEGDNQ---- 133
            :..|.||:.||....||..:.......::.: :||  ..||.:.|:| ...|:.|:...:|
Frog   278 RPHKDPSIWKAIYRAFGRPILLSSTFRYLADLLGF--AGPLCISGIV-QLLDSRNKGPTDQDFPK 339

  Fly   134 ---TKAYL----------YALGVILTSACNVLFMHPYMLGMFHI----GMKARIAMTSMIYRKAL 181
               :..|.          |.|.|:|..|  ::....::...:::    |:..|.|:.||||.|.|
Frog   340 TNFSSVYFLSSKGLIENYYVLAVLLFLA--LILQRTFLQASYYVTIETGINLRGALLSMIYNKIL 402

  Fly   182 RLSRT--ALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVA 244
            |||.:  ::|:.|:||:.||::.:..:|...:.....||..|::|.:...|:::.:|:||..|.|
Frog   403 RLSTSNMSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPIQIIMGVILLHKLVGVSALVGAA 467

  Fly   245 VMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEM 309
            |::|..|:|.::..|.:.::..|...:.||::..|||:.||:::|:||||..|...:...|.||:
Frog   468 VIVLLAPMQYFIATKLAEVQKNTLDYSTERLKKTNEILKGIKLLKLYAWENIFCNSVEETRIKEL 532

  Fly   310 NAIRNVNYIRGTLQSFIMFVTRISVFVS--------LVGFV----LLGKLLTAEKAFVITAYYNI 362
            .          :|::|.:. |.:|:|::        |..||    :....||...||...:.::|
Frog   533 K----------SLKTFALH-TSLSIFMNAAIPIAAVLATFVTHAYVSSSHLTPANAFASLSLFHI 586

  Fly   363 LRNTMTVYFPMG-ISQFA-ELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQT 425
            |   :|..|.:. :.:|| :.|||::::..|...:|  :|:     |..:.|:..|..|
Frog   587 L---VTPLFLLSTVVRFAVKALVSVQKLNEFFTSDE--IRE-----DGFRNGETTLPFE------ 635

  Fly   426 TGVLKPSSRRTSEAEHSIVISKLKA------KWDQ--------KNTDN----------------- 459
                   |.|.....||...::.:.      |:||        .:|::
Frog   636 -------SCRKHPGIHSRAFNRKQPLRYQMDKYDQAPKRQVRTSDTEDAALKVCGGFFSWGTGLA 693

  Fly   460 TLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSV--------------KVNG---- 506
            ||.||.::....:|..::|.||.|||||:.|:|||:....|.|              ..||
Frog   694 TLANIDIQIPTGELTMIVGQVGCGKSSLLLAILGEMQTLEGRVVWNKFGSQRRAPGSSANGWDSA 758

  Fly   507 ----------TLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIV 561
                      :::||.|:|||...|:.:||.||.|.:|.||:.|...|:|:.|.:|||:.|:|.:
Frog   759 CGSERSKNRHSVAYAGQKPWLLNATLEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEI 823

  Fly   562 GERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREE--IVLLVT 624
            ||||.:|||||:.||.:|||:|:..:|..||||.||:|.|:..||..:.:..||||:  .|:|||
Frog   824 GERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLREDKRTVVLVT 888

  Fly   625 HQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLD-FAQMLTDPSKKDEGAGDAPDKKSLSRQNS 688
            |:||:|..||.|:.|..|.:...||.:.:..:..: :....|..:::|:......|...::.:..
Frog   889 HKLQYLPHADWIIAMKDGSVLREGTLKDIQNNDNELYEHWKTLMNRQDQELEKDSDADQVTMERK 953

  Fly   689 KLRDRHGSISSMESAAESLAAESPMQTQEGRVEGR---IGMKLYKK--------YFGANGYGLFI 742
            .||      .:|.|....:.||...:.:|...|..   ..|:|..|        |..:.||.|..
Frog   954 TLR------RAMYSREAKVQAEEEEEEEEEEDEDETMSTAMRLRTKFPWRTCWRYLTSGGYLLLF 1012

  Fly   743 VFAFFCIGAQVLASGGDIFLSYWVNKNGE---AERDTFMARLRRAFPETRINADTDPVDIYYFTG 804
            :..|..:....:....|.:|:.|.::...   |:.|...:.           ::...:..||.||
Frog  1013 LMIFSKLLKHSVIVAIDYWLASWTSETSNISYAQSDNVTSA-----------SELSSIQSYYVTG 1066

  Fly   805 INV---SVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQV 866
            .:|   :.|:..|:.|:...::.:.::..||:.:.:.:..|.:.||:|.|.|.||||||.|...:
Frog  1067 FSVLSATGIVLCLIASLTVEWMGLNAAKNLHHNLLKKIILAPIRFFDTTPLGLILNRFSADTNII 1131

  Fly   867 DEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTR 931
            |:.:|..:..:.:..|..:..:.|:.......::|.:.|.:.||.::.::...|:|::.|:..|:
Frog  1132 DQHIPPTLESLTRSTLLCLSAIGVISYATPISMVALLPLGVAFYFIQKYFRVASKDLQELDDSTQ 1196

  Fly   932 SPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLD--------C 988
            .|:..|.|.:..||.|||||..:...........|.::..|....|.:|    ||:        |
Frog  1197 LPLLCHFSETAEGLTTIRAFRHEARFKQRMLELTDTNNLAYLFLSAANR----WLEVRTDYLGAC 1257

  Fly   989 VCVVYIAVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLE 1053
            : |:..||.::::.|    :.|.|||.:|.|:.:|..:.|.:|..|:||..:.||::|..:.::|
Frog  1258 I-VLTAAVFSITYGL----DSGIVGLGLTYALTVTNYLNWVVRNLADLEVQIGAVKKVNSFLNIE 1317

  Fly  1054 PEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGK 1118
            .|....|...::.|:|||:.|:|...||.::|  :.....||:.|...|:..:||||.||||:||
Frog  1318 SECYEGSMEQQQVPEDWPQSGEIRISDLCVRY--ENNHKPVLKHLKAYIKPGQKVGICGRTGSGK 1380

  Fly  1119 SSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAK 1182
            |||..|.||: ...:|.|:||..|.:.|.|:.|||::|||.|:|:||||::|:||||..:.||.:
Frog  1381 SSLSLAFFRMVDIFDGKIVIDGIDISKLPLNTLRSRLSIILQDPILFSGSIRFNLDPECKCSDER 1445

  Fly  1183 LWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQ 1247
            |||.|:..:||.:|..||.||.:.::|||.|||||||||.|||||.:|.:.||:||||||::|..
Frog  1446 LWEGLDIAQLKNLVKALPGGLDAMVTEGGENFSVGQRQLFCLARAFVRNSSILIMDEATASIDMA 1510

  Fly  1248 TDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVK 1312
            |:.::|..:...|.|.||:|||||:||::..|..:||..|..:|..:|..|| ..|..:|.|.|:
Frog  1511 TENILQKVVMTAFADRTVVTIAHRVHTILTGDVAIVMRRGNILEHDTPGNLL-AQEDSIFASFVR 1574

Fly 1313 1312
Frog 1575 1574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	424/1416 (30%)
		ABC_membrane	98..367	CDD:294371	80/304 (26%)
		ABCC_MRP_domain1	443..643	CDD:213217	91/260 (35%)
		ABC_membrane	799..1027	CDD:294371	63/238 (26%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	107/221 (48%)
abcc9	XP_031754288.1	MRP_assoc_pro	222..1574	CDD:188098	427/1427 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9436
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010