DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abcc8

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_031756190.1	Gene:	abcc8 / 101730668	-ID:	-	Length:	1580	Species:	Xenopus tropicalis

Alignment Length:	1333	Identity:	408/1333 - (30%)
Similarity:	666/1333 - (49%)	Gaps:	223/1333 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 QPLFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHI----GMKARIA 171
            ||:|||   .::  .|:||    ..|..|.|.|:|..|  :|....::...:::    |:..|.|
Frog   337 QPIFLG---VFF--ISSQE----FLANAYVLAVLLFFA--LLLQRSFLQASYYVAIETGINLRGA 390

  Fly   172 MTSMIYRKALRLSRT--ALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYRE 234
            :.:.||.|.:.||.:  ::|:.:.||:.||::.|..:|.........||..||:|.:...|:|..
Frog   391 IQTKIYNKIMHLSTSNMSMGEMSSGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYI 455

  Fly   235 IGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSK 299
            :||||..|..|:::..|:|.::..|.|..:..|...::||::..||::.||:::|:|:||..|..
Frog   456 LGISALIGAVVIIVLAPIQYFVATKLSQAQRSTLEYSNERLKKTNEMLRGIKLLKLYSWEHIFHS 520

  Fly   300 MINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVFVS--------LVGFVLLGKLLTAEK---- 352
            .:...|.||||          :|::|.:: |.||:|::        |:.||:...||..|:
Frog   521 SVEETRQKEMN----------SLKAFALY-TSISIFMNAAIPIAAVLITFVVHVHLLHREQFSPA 574

  Fly   353 -AFVITAYYNILRNTMTVYFPMG--ISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKA 414
             ||...:.::||   :|..|.:.  :....:.|||::::..|...||.     .|::::
Frog   575 VAFASLSLFHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFFSSEEI-----GEEVEK------ 625

  Fly   415 GLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISK-------LKAKWD-----QKNTDN-------- 459
                          ..||::...:.::..|..|       ::..|:     |:...|
Frog   626 --------------CPPSNKSVPQNKYQAVPLKVVNRKRPIRDDWNHFNSRQRGAPNPTEGNEFC 676

  Fly   460 ----------------TLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVN--- 505
                            .|.:|.::....||..::|.||.|||||:.|.|||::..||.|..|
Frog   677 IKVTSGFFTWTPDGPPALSSIDIRIPQGQLTMIVGQVGCGKSSLLLATLGEMHKISGDVSWNSTV 741

  Fly   506 ------------------------GTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCAL 546
                                    |.::||||:|||...||.:||.|..|.:|.:|:.::..|:|
Frog   742 PDSETGEDVNPDKETAIDVETRRRGAVAYASQKPWLLNATVEENITFESPFNKQKYKAIIDACSL 806

  Fly   547 ERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM 611
            :.|.::||:.|:|.:||||.:|||||:.|||:||.:|::..:..||||.||:|.|:..||..:.:
Frog   807 QPDIDILPHGDQTQIGERGINLSGGQRQRISVARVLYQQTSVVFLDDPFSALDIHLSDHLMHEGI 871

  Fly   612 RGFLRE--EIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGA 674
            ...||:  ...:||||:||:|..||.|:.|..|.|...||.:.:.||         ||...:..
Frog   872 LKMLRDNKRTTVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDIQKS---------DPELYEHW- 926

  Fly   675 GDAPDKKSLSRQNSKLR-----DRHG--------------------------SISSMESAAESLA 708
                 |..::||:.:|.     ||..                          .||..|...::|
Frog   927 -----KTLMNRQDQELEKEIILDRKAGGERMNLTRTIYPRDALLGDDEEDEEEISESEEDDDNL- 985

  Fly   709 AESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAE 773
              |.:..|..::..|    ...||..:.|    |:.....:.:|:|.....:.:.:|:.|...|.
Frog   986 --SSVLHQRAKMPWR----ACGKYLSSAG----ILLLPLLVLSQLLKHSVMVAIDFWLAKWTSAA 1040

  Fly   774 RDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQG 838
            ............|..|.  |..|..: .|:.::...||..|..|:...:..:|.:..||:::...
Frog  1041 ITNLSVANCSGRPTCRF--DHSPYSM-AFSILSCVGIIMCLATSIAVEWTGLRVAKKLHSSLLNA 1102

  Fly   839 VTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATV 903
            :..|.|.||.|.|.|.||||||.|...:|:.:|:.:..:.:..|..|..:.|:..:...::::.|
Frog  1103 IILAPMRFFETTPLGSILNRFSADFNTIDQHIPATLECLSRSTLLCVSALAVISYVTPVFLISLV 1167

  Fly   904 FLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMH 968
            .|.|:.|.::.::...|||:::||..|:.|:.||.:.::.||.|||||..:.....:...:.|.:
Frog  1168 PLAIICYFIQKYFRVASRDLQQLEDSTQLPLLSHFAETVEGLTTIRAFRYEPRFRQKLLEHTDSN 1232

  Fly   969 SSGYYMFLATSRAFGYWLDC------VCVVYIAVI-----TLSFFLFSPENGGDVGLAITQAMGM 1022
            :.......|.:|    ||:.      .|||.||.:     :|.:.|.|    |.|||.:|.|:.:
Frog  1233 NIASLFLTAANR----WLEVRMEYIGACVVLIAAVASITNSLHYNLSS----GLVGLGLTYALMV 1289

  Fly  1023 TGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFES--KPNKKPPKDWPEDGKIVFDDLSLKY 1085
            :..:.|.:|..:::|..:.||:|:......||| :::.  .|.:.|| :|||:|:|...:||::|
Frog  1290 SNYLNWMVRNLSDMEIQLGAVKRINGLLKTEPE-NYKGLLSPTQIPP-NWPENGEIQIQNLSVRY 1352

  Fly  1086 FPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHD 1149
              |.:...||:.:|..|...:|:||.||||:||||...|.||: ...:|.|:||..|...|.|..
Frog  1353 --DSSLKPVLKHVNAHITPGQKIGICGRTGSGKSSFSLAFFRMVDTFQGRIIIDGIDIAKLPLQT 1415

  Fly  1150 LRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNF 1214
            |||::|||.|:|:|||||:|:||||.::.:||.|||:||..:||.||..||.||.:.::|||.||
Frog  1416 LRSRLSIILQDPILFSGTIRFNLDPENKCTDAMLWEALEIAQLKHVVKVLPGGLDALVTEGGENF 1480

  Fly  1215 SVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSD 1279
            |||||||.|||||.:|::.||:||||||::|..|:.::|..:...|.|.||:|||||:||::::|
Frog  1481 SVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFDDRTVVTIAHRVHTILNAD 1545

  Fly  1280 KVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVK 1312
            .|:||..|..:|:..| |.|......:|.|.|:
Frog  1546 LVIVMKRGAIMEYDKP-EALLEGGGSMFASYVQ 1577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	404/1319 (31%)
		ABC_membrane	98..367	CDD:294371	80/274 (29%)
		ABCC_MRP_domain1	443..643	CDD:213217	86/264 (33%)
		ABC_membrane	799..1027	CDD:294371	66/238 (28%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	110/221 (50%)
abcc8	XP_031756190.1	MRP_assoc_pro	224..1573	CDD:188098	405/1327 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9436
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010