Protein Alignment Mrp5 and abcc8

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: XP_031756190.1
• Gene: abcc8 / 101730668
• -ID: -
• Length: 1580
• Species: Xenopus tropicalis
• Alignment Length: 1451
• Identity: 430/1451 - (29%)
• Similarity: 699/1451 - (48%)
• Gaps: 273/1451 - (18%)

  Fly    29 MPTFFK-GRKKTLDENDL------YRALQEHRSDHLGSKLSAAWEKEVEKKRKKKKTP------S 80
            |.||.| ..||.:|...:      .||:..:      ..|:.|:..:     |.|.:|      |
 Frog   233 MNTFIKTAHKKPIDLKAIGKLPIAMRAVTNY------LLLNKAFHSQ-----KSKSSPCPAGPKS 286

  Fly    81 LLKASMNVFGWRLAGLGLVLFILEIGFRV-------TQPLFLGGLVAYYAD-------------- 124
            :..|....||..|        ||...||:       ..||.:.|:|.:.:.
 Frog   287 IWFALCQAFGRPL--------ILSSIFRIMADMLGFAGPLCISGIVHHLSQENKTFHPQPIFLGV 343

  Fly   125 --ASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHI----GMKARIAMTSMIYRKALRL 183
              .|:||    ..|..|.|.|:|..|  :|....::...:::    |:..|.|:.:.||.|.:.|
 Frog   344 FFISSQE----FLANAYVLAVLLFFA--LLLQRSFLQASYYVAIETGINLRGAIQTKIYNKIMHL 402

  Fly   184 SRT--ALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVM 246
            |.:  ::|:.:.||:.||::.|..:|.........||..||:|.:...|:|..:||||..|..|:
 Frog   403 STSNMSMGEMSSGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGISALIGAVVI 467

  Fly   247 LLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNA 311
            ::..|:|.::..|.|..:..|...::||::..||::.||:::|:|:||..|...:...|.||||
 Frog   468 IVLAPIQYFVATKLSQAQRSTLEYSNERLKKTNEMLRGIKLLKLYSWEHIFHSSVEETRQKEMN- 531

  Fly   312 IRNVNYIRGTLQSFIMFVTRISVFVS--------LVGFVLLGKLLTAEK-----AFVITAYYNIL 363
                     :|::|.:: |.||:|::        |:.||:...||..|:     ||...:.::||
 Frog   532 ---------SLKAFALY-TSISIFMNAAIPIAAVLITFVVHVHLLHREQFSPAVAFASLSLFHIL 586

  Fly   364 RNTMTVYFPMG--ISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTT 426
               :|..|.:.  :....:.|||::::..|...||.     .|::::
 Frog   587 ---VTPLFLLSSVVRSTVKALVSVQKLSEFFSSEEI-----GEEVEK------------------ 625

  Fly   427 GVLKPSSRRTSEAEHSIVISK-------LKAKWD-----QKNTDN-------------------- 459
              ..||::...:.::..|..|       ::..|:     |:...|
 Frog   626 --CPPSNKSVPQNKYQAVPLKVVNRKRPIRDDWNHFNSRQRGAPNPTEGNEFCIKVTSGFFTWTP 688

  Fly   460 ----TLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVN--------------- 505
                .|.:|.::....||..::|.||.|||||:.|.|||::..||.|..|
 Frog   689 DGPPALSSIDIRIPQGQLTMIVGQVGCGKSSLLLATLGEMHKISGDVSWNSTVPDSETGEDVNPD 753

  Fly   506 ------------GTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADK 558
                        |.::||||:|||...||.:||.|..|.:|.:|:.::..|:|:.|.::||:.|:
 Frog   754 KETAIDVETRRRGAVAYASQKPWLLNATVEENITFESPFNKQKYKAIIDACSLQPDIDILPHGDQ 818

  Fly   559 TIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLRE--EIVL 621
            |.:||||.:|||||:.|||:||.:|::..:..||||.||:|.|:..||..:.:...||:  ...:
 Frog   819 TQIGERGINLSGGQRQRISVARVLYQQTSVVFLDDPFSALDIHLSDHLMHEGILKMLRDNKRTTV 883

  Fly   622 LVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQ 686
            ||||:||:|..||.|:.|..|.|...||.:.:.||         ||...:..      |..::||
 Frog   884 LVTHKLQYLPHADWIIAMKDGTIQREGTLKDIQKS---------DPELYEHW------KTLMNRQ 933

  Fly   687 NSKLR-----DRHG--------------------------SISSMESAAESLAAESPMQTQEGRV 720
            :.:|.     ||..                          .||..|...::|   |.:..|..::
 Frog   934 DQELEKEIILDRKAGGERMNLTRTIYPRDALLGDDEEDEEEISESEEDDDNL---SSVLHQRAKM 995

  Fly   721 EGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAF 785
            ..|    ...||..:.|    |:.....:.:|:|.....:.:.:|:.|...|.............
 Frog   996 PWR----ACGKYLSSAG----ILLLPLLVLSQLLKHSVMVAIDFWLAKWTSAAITNLSVANCSGR 1052

  Fly   786 PETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTN 850
            |..|.  |..|..: .|:.::...||..|..|:...:..:|.:..||:::...:..|.|.||.|.
 Frog  1053 PTCRF--DHSPYSM-AFSILSCVGIIMCLATSIAVEWTGLRVAKKLHSSLLNAIILAPMRFFETT 1114

  Fly   851 PSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVF 915
            |.|.||||||.|...:|:.:|:.:..:.:..|..|..:.|:..:...::::.|.|.|:.|.::.:
 Frog  1115 PLGSILNRFSADFNTIDQHIPATLECLSRSTLLCVSALAVISYVTPVFLISLVPLAIICYFIQKY 1179

  Fly   916 YLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSR 980
            :...|||:::||..|:.|:.||.:.::.||.|||||..:.....:...:.|.::.......|.:|
 Frog  1180 FRVASRDLQQLEDSTQLPLLSHFAETVEGLTTIRAFRYEPRFRQKLLEHTDSNNIASLFLTAANR 1244

  Fly   981 AFGYWLDC------VCVVYIAVI-----TLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSA 1034
                ||:.      .|||.||.:     :|.:.|.|    |.|||.:|.|:.::..:.|.:|..:
 Frog  1245 ----WLEVRMEYIGACVVLIAAVASITNSLHYNLSS----GLVGLGLTYALMVSNYLNWMVRNLS 1301

  Fly  1035 ELENTMTAVERVVEYEDLEPEGDFES--KPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRS 1097
            ::|..:.||:|:......||| :::.  .|.:.|| :|||:|:|...:||::|  |.:...||:.
 Frog  1302 DMEIQLGAVKRINGLLKTEPE-NYKGLLSPTQIPP-NWPENGEIQIQNLSVRY--DSSLKPVLKH 1362

  Fly  1098 LNIAIEGCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEP 1161
            :|..|...:|:||.||||:||||...|.||: ...:|.|:||..|...|.|..|||::|||.|:|
 Frog  1363 VNAHITPGQKIGICGRTGSGKSSFSLAFFRMVDTFQGRIIIDGIDIAKLPLQTLRSRLSIILQDP 1427

  Fly  1162 VLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLAR 1226
            :|||||:|:||||.::.:||.|||:||..:||.||..||.||.:.::|||.|||||||||.||||
 Frog  1428 ILFSGTIRFNLDPENKCTDAMLWEALEIAQLKHVVKVLPGGLDALVTEGGENFSVGQRQLFCLAR 1492

  Fly  1227 AILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVE 1291
            |.:|::.||:||||||::|..|:.::|..:...|.|.||:|||||:||::::|.|:||..|..:|
 Frog  1493 AFVRKSSILIMDEATASIDMATENILQKVVMTAFDDRTVVTIAHRVHTILNADLVIVMKRGAIME 1557

  Fly  1292 FGSPFELLTTSEKKVFHSMVK 1312
            :..| |.|......:|.|.|:
 Frog  1558 YDKP-EALLEGGGSMFASYVQ 1577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	417/1394 (30%)
abcc8	XP_031756190.1	MRP_assoc_pro	224..1573	CDD:188098	427/1445 (30%)