DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCC5

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_005679.2	Gene:	ABCC5 / 10057	HGNCID:	56	Length:	1437	Species:	Homo sapiens

Alignment Length:	1378	Identity:	461/1378 - (33%)
Similarity:	744/1378 - (53%)	Gaps:	128/1378 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ENPREKSNIFSSLMFCFAMPTFFKGRKK-TLDENDLYRALQEHRSDHLG-SKLSAAWEKEVEKKR 73
            ::|.:.:.:||.:.|.:.........|| .|...|:: :|.:|.|..:. .:|...|::|:.:..
Human    98 QHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVW-SLSKHESSDVNCRRLERLWQEELNEVG 161

  Fly    74 KKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQ------PLFLGGLVAYYADASNQEGDN 132
            ..       .||:....|......|:|.|  :...:||      |.|:...:..|..|:.   .|
Human   162 PD-------AASLRRVVWIFCRTRLILSI--VCLMITQLAGFSGPAFMVKHLLEYTQATE---SN 214

  Fly   133 QTKAYLYALGVILTSACNVLFMHPYMLGM-----FHIGMKARIAMTSMIYRKALRLSRTALGDTT 192
            ...:.|..||::||.     .:..:.|.:     :..|::.|.|:.:|.::|.|:|..  :.:.:
Human   215 LQYSLLLVLGLLLTE-----IVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKN--IKEKS 272

  Fly   193 IGQVVNLISNDVGRLDVSVIHMNYLWLGPVE--IGIITYLMYREIGISAFFGVAVMLLFIPLQAY 255
            :|:::|:.|||..|:..:....:.|..|||.  :|:|..::.  :|.:.|.|.||.:||.|...:
Human   273 LGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVII--LGPTGFLGSAVFILFYPAMMF 335

  Fly   256 LGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRG 320
            ..:.|:..|.|....|||||:.|||:::.|:.||||||...||:.:..:|.:|...:....|
Human   336 ASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGY--- 397

  Fly   321 TLQSFIMFVTRISVFV-SLVGF---VLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAEL 381
             .||..:.|..|.|.: |:|.|   :.||..|||.:||.:...:|.:...:.| .|..:...:|.
Human   398 -FQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKV-TPFSVKSLSEA 460

  Fly   382 LVSIRRIQTFMLHEET---KVRDKSEDLD-EQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEA--- 439
            .|::.|.::..|.||.   |.:..|..:. |.|.......:..:..|.:..|.|..::...|
Human   461 SVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRG 525

  Fly   440 -----------EHSIVISKLKAKW----DQK----------------NTDNTLDNISLKFKPRQL 473
                       ||..|:::.|...    |::                ....||.:|.|:.:..:|
Human   526 KKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKL 590

  Fly   474 VAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYR 538
            |.:.|.|||||:|||.|:||::....||:.::||.:|.:|:.|:...|:|.|||||...|:.||.
Human   591 VGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYN 655

  Fly   539 TVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVG 603
            :|:..|.|..|..:||.:|.|.:|||||:|||||:.|||||||:|....||:|||||||:|.|||
Human   656 SVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVG 720

  Fly   604 RHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPS 668
            .|:|:..:|..|:.:.||.||||||:|...|.::.|.:|.|:..||:|.:.....|:|.:..:..
Human   721 NHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLL 785

  Fly   669 KKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYF 733
            ..:....:...||..|....|.:|:.....|::........|..:...|.:.:|.:...:|..|.
Human   786 LGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYI 850

  Fly   734 GANG--YGLFIVFAFFC--IGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRI-NAD 793
            .|.|  ....::.|.|.  :|:...::.   :||||: |.|..  :|.:.|..    ||.: ::.
Human   851 QAAGGPLAFLVIMALFMLNVGSTAFSTW---WLSYWI-KQGSG--NTTVTRGN----ETSVSDSM 905

  Fly   794 TDPVDIYYFTGI---NVSV-IIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGR 854
            .|...:.|:..|   :::| :|...:|.::|....:|:|:.||:.:|:.:.|:.|.||:|.|:||
Human   906 KDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGR 970

  Fly   855 ILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCI-----INVWYILATVFLVIVFYLLRV 914
            ||||||||:.:||..||.    ..::|:..| |:|..|:     :..|:::|...|||:|.:|.:
Human   971 ILNRFSKDMDEVDVRLPF----QAEMFIQNV-ILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHI 1030

  Fly   915 FYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATS 979
            ......|::|||:.:|:||..||:::|:.|||||.|:...:|.:..:....|.:.:.:::|....
Human  1031 VSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAM 1095

  Fly   980 RAFGYWLDCVCVVYIAVITLSFFLFSPENGGDV-----GLAITQAMGMTGMVQWGMRQSAELENT 1039
            |.....||.:.:..|....|...|..    |.:     ||||:.|:.:||:.|:.:|.::|.|..
Human  1096 RWLAVRLDLISIALITTTGLMIVLMH----GQIPPAYAGLAISYAVQLTGLFQFTVRLASETEAR 1156

  Fly  1040 MTAVERVVEY-EDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIE 1103
            .|:|||:..| :.|..|.....| ||.|..|||::|::.|::..::|  .:....||:.::..|:
Human  1157 FTSVERINHYIKTLSLEAPARIK-NKAPSPDWPQEGEVTFENAEMRY--RENLPLVLKKVSFTIK 1218

  Fly  1104 GCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGT 1167
            ..||:|||||||:|||||..||||| ..:.|.|.||....:|:||.|||||:|||||||||||||
Human  1219 PKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGT 1283

  Fly  1168 MRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILREN 1232
            :|.|||||::|::.::|::||...:|:.:|.||..|:|::.|.|.|||||:|||:|:|||:||..
Human  1284 VRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHC 1348

  Fly  1233 RILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFE 1297
            :||::|||||.:|.:||.|||.|||..|.|||:||||||||||:.||:::|:..|:.|||.:|..
Human  1349 KILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSV 1413

  Fly  1298 LLTTSEKKVFHSM 1310
            ||:....: |::|
Human  1414 LLSNDSSR-FYAM 1425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	458/1365 (34%)
		ABC_membrane	98..367	CDD:294371	82/285 (29%)
		ABCC_MRP_domain1	443..643	CDD:213217	92/219 (42%)
		ABC_membrane	799..1027	CDD:294371	76/241 (32%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	119/221 (54%)
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..41
		CFTR_protein	100..1430	CDD:273530	461/1376 (34%)
		ABC_membrane	<271..447	CDD:294371	59/181 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..538		4/36 (11%)
		ABCC_MRP_domain1	577..759	CDD:213217	89/181 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..827		6/32 (19%)
		ABC_membrane	863..1143	CDD:294371	90/298 (30%)
		ABCC_MRP_domain2	1191..1411	CDD:213211	119/221 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151529
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.660