DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4562 and ice1

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_002935180.3	Gene:	ice1 / 100498517	XenbaseID:	XB-GENE-6044166	Length:	2065	Species:	Xenopus tropicalis

Alignment Length:	356	Identity:	75/356 - (21%)
Similarity:	133/356 - (37%)	Gaps:	83/356 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 SIRRIQTFMLH---------EETKVRDKSEDLDEQKLGKAGLIAEPTVA--QTTGVLKPSSRRTS 437
            ||..|||....         |||..|..::.:::...|...|::....|  ::|...|.:|.::
Frog   870 SISTIQTLSDEDGEHYQGETEETPDRRNTDKIEKTVDGSTNLLSMSLAAFEKSTKACKINSNKS- 933

  Fly   438 EAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSV 502
               |.|           .|::.|.:| :||   :|....:....:|...|::...|. |||:...
Frog   934 ---HLI-----------NNSEQTFEN-TLK---KQTNIKVSEEKNGSQDLVRIDSGS-NPDNHIP 979

  Fly   503 KVNGTLSYASQE---------PWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADK 558
            |...:.|...||         |..||.:       .:|..|    |.:.:|     .|.||...|
Frog   980 KFKLSSSKHGQEHGHLLLNRKPAFFTES-------NIPPPK----TEILKC-----IESLPEHSK 1028

  Fly   559 TIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVL-- 621
             |..|:       .|..|:.:.......|:::  .|.:.|.|.....|..:..:..|::..|:
Frog  1029 -IPSEQ-------TKENITSSDRFLHSTDLHV--KPANEVVTESYHQLLSKTSKLSLKDTDVMGT 1083

  Fly   622 -LVTHQLQFLEQADVIVIMD-KGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKK--- 681
             |....::.|:.|::..|.: :.|||...:..|:.|....:.....|   .|:...|.|.:|
Frog  1084 SLREINIKSLQAANLQEIQNSENKISEQSSVLSIFKMKEMYRSGYID---SDDSEDDFPVRKVNY 1145

  Fly   682 -------SLSRQNSKLRDRHGSISSMESAAE 705
                   |.:..|:.|..::.:..:.|.||:
Frog  1146 AKFSSDNSAASANASLNLQNANKDTSELAAD 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	75/356 (21%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217	43/212 (20%)
		ABC_membrane	799..1027	CDD:294371
		ABCC_MRP_domain2	1074..1295	CDD:213211
ice1	XP_002935180.3	Cast	<25..249	CDD:401982
ice1	XP_002935180.3	Herpes_BLLF1	<1409..1692	CDD:282904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165170318
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930