DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4562 and abcc12

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:XP_002937916.3 Gene:abcc12 / 100493828 XenbaseID:XB-GENE-6465370 Length:1430 Species:Xenopus tropicalis


Alignment Length:1446 Identity:456/1446 - (31%)
Similarity:753/1446 - (52%) Gaps:180/1446 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MQSMKADELPENPREKSNIFSSLMFCFAMPTFFKGRK-KTLDENDLYRALQEHRSDHLG-SKLSA 63
            ::..:|....::|.:.:.:||.:...:..|...|..| ..|..|||: :|..|.|.... .:|.:
 Frog    19 LKPFRATHRNQHPIDNAGLFSFMTLNWITPLARKAYKLSELQMNDLW-SLPFHESSETNCQRLQS 82

  Fly    64 AWEKEVEKKRKKKKTPSLLKASMNVFGWR-------LAGLGLVLFILEIGFRVTQPLFLGGLVAY 121
            .||:|::...|:       |||:::..||       ||.|.|:: .:...| :...:|:..|:.|
 Frog    83 LWEEELQNHGKR-------KASLSLVLWRFCRTRSLLAFLSLII-TMTASF-IGPAIFIRALLEY 138

  Fly   122 YADASNQEGDNQTKAYLYALGVILTS---ACNVLFMHPYMLGM---FHIGMKARIAMTSMIYRKA 180
               |:..:.|       ...|:||.|   |..::....:.|..   :..|::.:.|:.::.::|.
 Frog   139 ---ANTLKHD-------LRYGLILASGIFAAELVRSWSFALHWAMNYRTGVRLKGAVLALAFKKM 193

  Fly   181 LRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYRE--IGISAFFGV 243
            |:|.::  .|...|:::|:.|:|..||..:......|..||| |||:. |:|..  :|.||..|.
 Frog   194 LKLKQS--NDIRTGELLNMCSSDGQRLFEAASIGCMLAAGPV-IGIMG-LVYTALFLGPSALLGS 254

  Fly   244 AVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKE 308
            :|.::|.|......|.|:..|.|..:.||.|||:||||::.|:.|||||||..|...|..:|::|
 Frog   255 SVFIIFYPFMMLASKLTAYFRKKCIVVTDRRVRLMNEILNSIKFIKMYAWENTFRNKIQDIRSEE 319

  Fly   309 MNAIRNVNYIRGTLQSFIMFVTRISVFV-SLVGFVL---LGKLLTAEKAFVITAYYNILRNTMTV 369
            ...:....|:    ||....|..:.|.| |:..|.|   ||..|.|.:||.:...:|.:.:.:.:
 Frog   320 KTFLEKAGYV----QSITSGVAPVVVVVASVCTFTLHMALGYNLNAAEAFTVVTVFNSMTSALKM 380

  Fly   370 YFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSR 434
             .|:.:...:|..:||.|.|...|.||:.:|:....|....:..:|..    .:.::.|...:..
 Frog   381 -IPLAVKAASEASISISRFQKLFLMEESDMRNNQRLLSNDLIDFSGAY----FSWSSDVRSSTLE 440

  Fly   435 RTSEAEHS--------------IVISKLKAKWDQKNTDNT----------LDNISLKFKPRQLVA 475
            :..|||..              .:.|..::|.....|:.:          |.||:...:..:|:.
 Frog   441 KQKEAEQKQEEFKETQNLINGHYLFSSSESKQIVNGTNASEYIVCEHKAALININFTVQKSKLIG 505

  Fly   476 VIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTV 540
            :.|.|||||:|||.::||::....|:|.|:|.::||:|:.|:|..::|:|||||....:.:|:.|
 Frog   506 ICGSVGSGKTSLILSILGQMTLLEGTVTVSGRIAYAAQQAWIFNESLRENILFGEEYKEKKYQRV 570

  Fly   541 VKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRH 605
            :|.|.|..|.|.||:.|.|.:||||.:|||||:.|||||||:|.:..:.||||||||||..||..
 Frog   571 LKTCCLYPDIESLPHGDLTEIGERGTNLSGGQRQRISLARALYSERSVVLLDDPLSAVDVQVGAQ 635

  Fly   606 LFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKK 670
            ||.:.::..:...|||.||||||:|.:.|.:::|..|.|:..||:|.:.|...|:|.:.....:.
 Frog   636 LFKKAIKHGMMNRIVLFVTHQLQYLVECDEVLMMKNGSIAEQGTHEELMKYQGDYAVLFQSMQQV 700

  Fly   671 DEGAGD---APDK-KSLSR-----------QNSK---------LRDRHGSISSMESAAESLAAES 711
            :....|   :|.| :.|.|           |.||         .::..|..:|.:.:|:.|..:|
 Frog   701 NSIKSDVQCSPMKYEQLDRQVTSSHHATVVQQSKEQGTLSELTNQEETGHFTSEDVSADHLTHKS 765

  Fly   712 PM-----------------------------QTQEGRVEGR------------------------ 723
            .|                             :.::|.|.|.                        
 Frog   766 EMVNRDFMVTDGQITGCKQADQYGDQEDDADEDEKGSVLGNTIIVNNNERQNRDLMEPEEKGCGS 830

  Fly   724 IGMKLYKKYFGANGYGLF----IVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRA 784
            :...:|..|..|.|..||    .|...|..|:...::.   :||||: |.|........:.:..:
 Frog   831 VPCPIYWVYIKAAGGALFCVLNAVLFIFTTGSMAFSNW---WLSYWI-KQGSGNTSVVTSNVTLS 891

  Fly   785 FPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNT 849
            ......|.|.: ..||.:.....:|:.|..:|..:|....:::||.||:.:||.|..:.:..|:|
 Frog   892 SDNMSDNPDLE-FYIYVYISTLAAVLGFRFIRGYVFVKSTLKASTKLHDQLFQKVLHSPLKLFDT 955

  Fly   850 NPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRV 914
            .|.|||||||:||:.:||..||..:..::|..:.::..:.::..:..|::::.:.|.|:|:|:..
 Frog   956 TPLGRILNRFTKDMDEVDARLPCQLEQLIQNMILVLFCLGMISFVFPWFLVSVLPLSILFFLINK 1020

  Fly   915 FYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATS 979
            ......|::|||:.:::||..||::|||:|:.||:|:....:.|..|....|::....::|...|
 Frog  1021 VSRVLIRELKRLDNISQSPFLSHVTASLHGITTIQAYNKNTDFILRFQKLLDINQVPCFLFSCAS 1085

  Fly   980 RAFGYWLDCVCVVYIAVITLSFFLFSPENGGDV-----GLAITQAMGMTGMVQWGMRQSAELENT 1039
            |.....||.:.::.|.:.::...|..    |.:     ||||:.|:.:||:.|:.:|...|.|..
 Frog  1086 RWLAVRLDLISMIVITLTSVCIVLMH----GHIPPAYAGLAISYAVQLTGLFQYTVRLVTETEAR 1146

  Fly  1040 MTAVERVVEY-EDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIE 1103
            .|:|||:..| ::||.|...::|  :..||.||::|.|.|:::.::| .|| ...||::::.:|.
 Frog  1147 FTSVERINHYIKNLESEEPLKAK--EITPKTWPQEGAITFENVEMRY-RDK-LPLVLKNISFSIR 1207

  Fly  1104 GCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGT 1167
            ..||:|||||||:|||||...|||| ....|::.||....|.:||.:||.|:|::||:||||.|:
 Frog  1208 PKEKIGIVGRTGSGKSSLGMVLFRLVDLAGGSVTIDNFCINTIGLKNLRGKLSVLPQDPVLFVGS 1272

  Fly  1168 MRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILREN 1232
            :|.||||.:.::|.::|.:||...:||.|:.|...|..::||.|:|||||:|||:|:|||:||.:
 Frog  1273 IRSNLDPLNLHTDEEVWNALERTHMKQHVSKLVGKLNYEVSENGSNFSVGERQLLCMARALLRSS 1337

  Fly  1233 RILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFE 1297
            ::|::|||||.:|.:||||||.|::..|.|||||.|||||:|::..|:::|||.||.|||..| .
 Frog  1338 KVLLLDEATAAIDNETDALIQETVKEAFHDCTVLIIAHRLNTILHCDRIMVMDKGKIVEFEKP-S 1401

  Fly  1298 LLTTSEKKVFHSMVKQ 1313
            :|.:::|..||:|..|
 Frog  1402 VLLSNKKSRFHAMATQ 1417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 449/1420 (32%)
ABC_membrane 98..367 CDD:294371 82/280 (29%)
ABCC_MRP_domain1 443..643 CDD:213217 87/209 (42%)
ABC_membrane 799..1027 CDD:294371 68/232 (29%)
ABCC_MRP_domain2 1074..1295 CDD:213211 110/221 (50%)
abcc12XP_002937916.3 MRP_assoc_pro 27..1415 CDD:188098 453/1434 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.010

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