Protein Alignment Mrp5 and abcc12

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: XP_002937916.3
• Gene: abcc12 / 100493828
• XenbaseID: XB-GENE-6465370
• Length: 1430
• Species: Xenopus tropicalis
• Alignment Length: 1446
• Identity: 456/1446 - (31%)
• Similarity: 753/1446 - (52%)
• Gaps: 180/1446 - (12%)

  Fly     1 MQSMKADELPENPREKSNIFSSLMFCFAMPTFFKGRK-KTLDENDLYRALQEHRSDHLG-SKLSA 63
            ::..:|....::|.:.:.:||.:...:..|...|..| ..|..|||: :|..|.|.... .:|.:
 Frog    19 LKPFRATHRNQHPIDNAGLFSFMTLNWITPLARKAYKLSELQMNDLW-SLPFHESSETNCQRLQS 82

  Fly    64 AWEKEVEKKRKKKKTPSLLKASMNVFGWR-------LAGLGLVLFILEIGFRVTQPLFLGGLVAY 121
            .||:|::...|:       |||:::..||       ||.|.|:: .:...| :...:|:..|:.|
 Frog    83 LWEEELQNHGKR-------KASLSLVLWRFCRTRSLLAFLSLII-TMTASF-IGPAIFIRALLEY 138

  Fly   122 YADASNQEGDNQTKAYLYALGVILTS---ACNVLFMHPYMLGM---FHIGMKARIAMTSMIYRKA 180
               |:..:.|       ...|:||.|   |..::....:.|..   :..|::.:.|:.::.::|.
 Frog   139 ---ANTLKHD-------LRYGLILASGIFAAELVRSWSFALHWAMNYRTGVRLKGAVLALAFKKM 193

  Fly   181 LRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYRE--IGISAFFGV 243
            |:|.::  .|...|:::|:.|:|..||..:......|..||| |||:. |:|..  :|.||..|.
 Frog   194 LKLKQS--NDIRTGELLNMCSSDGQRLFEAASIGCMLAAGPV-IGIMG-LVYTALFLGPSALLGS 254

  Fly   244 AVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKE 308
            :|.::|.|......|.|:..|.|..:.||.|||:||||::.|:.|||||||..|...|..:|::|
 Frog   255 SVFIIFYPFMMLASKLTAYFRKKCIVVTDRRVRLMNEILNSIKFIKMYAWENTFRNKIQDIRSEE 319

  Fly   309 MNAIRNVNYIRGTLQSFIMFVTRISVFV-SLVGFVL---LGKLLTAEKAFVITAYYNILRNTMTV 369
            ...:....|:    ||....|..:.|.| |:..|.|   ||..|.|.:||.:...:|.:.:.:.:
 Frog   320 KTFLEKAGYV----QSITSGVAPVVVVVASVCTFTLHMALGYNLNAAEAFTVVTVFNSMTSALKM 380

  Fly   370 YFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSR 434
             .|:.:...:|..:||.|.|...|.||:.:|:....|....:..:|..    .:.::.|...:..
 Frog   381 -IPLAVKAASEASISISRFQKLFLMEESDMRNNQRLLSNDLIDFSGAY----FSWSSDVRSSTLE 440

  Fly   435 RTSEAEHS--------------IVISKLKAKWDQKNTDNT----------LDNISLKFKPRQLVA 475
            :..|||..              .:.|..::|.....|:.:          |.||:...:..:|:.
 Frog   441 KQKEAEQKQEEFKETQNLINGHYLFSSSESKQIVNGTNASEYIVCEHKAALININFTVQKSKLIG 505

  Fly   476 VIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTV 540
            :.|.|||||:|||.::||::....|:|.|:|.::||:|:.|:|..::|:|||||....:.:|:.|
 Frog   506 ICGSVGSGKTSLILSILGQMTLLEGTVTVSGRIAYAAQQAWIFNESLRENILFGEEYKEKKYQRV 570

  Fly   541 VKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRH 605
            :|.|.|..|.|.||:.|.|.:||||.:|||||:.|||||||:|.:..:.||||||||||..||..
 Frog   571 LKTCCLYPDIESLPHGDLTEIGERGTNLSGGQRQRISLARALYSERSVVLLDDPLSAVDVQVGAQ 635

  Fly   606 LFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKK 670
            ||.:.::..:...|||.||||||:|.:.|.:::|..|.|:..||:|.:.|...|:|.:.....:.
 Frog   636 LFKKAIKHGMMNRIVLFVTHQLQYLVECDEVLMMKNGSIAEQGTHEELMKYQGDYAVLFQSMQQV 700

  Fly   671 DEGAGD---APDK-KSLSR-----------QNSK---------LRDRHGSISSMESAAESLAAES 711
            :....|   :|.| :.|.|           |.||         .::..|..:|.:.:|:.|..:|
 Frog   701 NSIKSDVQCSPMKYEQLDRQVTSSHHATVVQQSKEQGTLSELTNQEETGHFTSEDVSADHLTHKS 765

  Fly   712 PM-----------------------------QTQEGRVEGR------------------------ 723
            .|                             :.::|.|.|.
 Frog   766 EMVNRDFMVTDGQITGCKQADQYGDQEDDADEDEKGSVLGNTIIVNNNERQNRDLMEPEEKGCGS 830

  Fly   724 IGMKLYKKYFGANGYGLF----IVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRA 784
            :...:|..|..|.|..||    .|...|..|:...::.   :||||: |.|........:.:..:
 Frog   831 VPCPIYWVYIKAAGGALFCVLNAVLFIFTTGSMAFSNW---WLSYWI-KQGSGNTSVVTSNVTLS 891

  Fly   785 FPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNT 849
            ......|.|.: ..||.:.....:|:.|..:|..:|....:::||.||:.:||.|..:.:..|:|
 Frog   892 SDNMSDNPDLE-FYIYVYISTLAAVLGFRFIRGYVFVKSTLKASTKLHDQLFQKVLHSPLKLFDT 955

  Fly   850 NPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRV 914
            .|.|||||||:||:.:||..||..:..::|..:.::..:.::..:..|::::.:.|.|:|:|:..
 Frog   956 TPLGRILNRFTKDMDEVDARLPCQLEQLIQNMILVLFCLGMISFVFPWFLVSVLPLSILFFLINK 1020

  Fly   915 FYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATS 979
            ......|::|||:.:::||..||::|||:|:.||:|:....:.|..|....|::....::|...|
 Frog  1021 VSRVLIRELKRLDNISQSPFLSHVTASLHGITTIQAYNKNTDFILRFQKLLDINQVPCFLFSCAS 1085

  Fly   980 RAFGYWLDCVCVVYIAVITLSFFLFSPENGGDV-----GLAITQAMGMTGMVQWGMRQSAELENT 1039
            |.....||.:.::.|.:.::...|..    |.:     ||||:.|:.:||:.|:.:|...|.|..
 Frog  1086 RWLAVRLDLISMIVITLTSVCIVLMH----GHIPPAYAGLAISYAVQLTGLFQYTVRLVTETEAR 1146

  Fly  1040 MTAVERVVEY-EDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIE 1103
            .|:|||:..| ::||.|...::|  :..||.||::|.|.|:::.::| .|| ...||::::.:|.
 Frog  1147 FTSVERINHYIKNLESEEPLKAK--EITPKTWPQEGAITFENVEMRY-RDK-LPLVLKNISFSIR 1207

  Fly  1104 GCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGT 1167
            ..||:|||||||:|||||...|||| ....|::.||....|.:||.:||.|:|::||:||||.|:
 Frog  1208 PKEKIGIVGRTGSGKSSLGMVLFRLVDLAGGSVTIDNFCINTIGLKNLRGKLSVLPQDPVLFVGS 1272

  Fly  1168 MRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILREN 1232
            :|.||||.:.::|.::|.:||...:||.|:.|...|..::||.|:|||||:|||:|:|||:||.:
 Frog  1273 IRSNLDPLNLHTDEEVWNALERTHMKQHVSKLVGKLNYEVSENGSNFSVGERQLLCMARALLRSS 1337

  Fly  1233 RILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFE 1297
            ::|::|||||.:|.:||||||.|::..|.|||||.|||||:|::..|:::|||.||.|||..| .
 Frog  1338 KVLLLDEATAAIDNETDALIQETVKEAFHDCTVLIIAHRLNTILHCDRIMVMDKGKIVEFEKP-S 1401

  Fly  1298 LLTTSEKKVFHSMVKQ 1313
            :|.:::|..||:|..|
 Frog  1402 VLLSNKKSRFHAMATQ 1417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	437/1366 (32%)
abcc12	XP_002937916.3	MRP_assoc_pro	27..1415	CDD:188098	453/1434 (32%)