Protein Alignment CG4562 and abcc6

DIOPT Version :9

• Sequence 1: NP_001262747.1
• Gene: CG4562 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: XP_002932264.3
• Gene: abcc6 / 100493037
• XenbaseID: XB-GENE-6465366
• Length: 1500
• Species: Xenopus tropicalis
• Alignment Length: 1379
• Identity: 467/1379 - (33%)
• Similarity: 740/1379 - (53%)
• Gaps: 169/1379 - (12%)

  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEK----KR 73
            |..:|:..|.:.|.:.....|:|.|:.|...|::...:...::.:.:..|...|||.:|    |.
 Frog   207 PVSESSFLSKVTFSWFTEIMFRGYKQPLKAEDVWSLRKSDTAEEILTLFSKGVEKECKKANLLKE 271

  Fly    74 KKKKTPS-------------------------------LLKASMNVFGWRLAGLGLVLFILEIGF 107
            ..:.:||                               |||..|..||.... |..:|......|
 Frog   272 PTRFSPSTLDNDMWISQTEKSEIELLLKNQHIQLSQKTLLKVIMRSFGLYFL-LSALLMTFYTAF 335

  Fly   108 RVTQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAM 172
            ....||.:..|:....|.|..    ..:.:|.|:.:.:...|..||:|.:....:.|||:.|.|:
 Frog   336 LFISPLLVRLLLQLLKDPSAP----SWQGFLVAVFLFICPCCQSLFLHQHDYICYVIGMRLRAAI 396

  Fly   173 TSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGI 237
            ...:|:|||.:|.....:::.|::|||||.||.:|......:||:|..||.|.:..|.:::.:||
 Frog   397 VGTVYKKALMISSAGRKESSAGEIVNLISTDVQKLMDLATCVNYMWSAPVTIIVAMYFLWQTLGI 461

  Fly   238 SAFFGVAVMLLFIPLQ---AYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSK 299
            :...||||.:|.:|..   |.:.|:....::|   :.|.|:::::||:.||:|:|:||||..|.|
 Frog   462 AVLAGVAVFILNLPFMTVFAVIIKRVQEQQMK---QKDGRIKIISEILQGIKVLKLYAWENAFMK 523

  Fly   300 MINYVRTKEMNAIR-NVNYIRGTLQSFI-----MFVTRISVFVSLVGFVLLGKLLTAEKAFVITA 358
            .:...|..|:.|:: ....:.|.|..|:     :.:|...||::|..    ..:|.||||||...
 Frog   524 KVTEFRLMELKAVKTGALLLSGALAVFVASPFWVSLTMFGVFLALDE----KNILDAEKAFVTII 584

  Fly   359 YYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVA 423
            ..||||..:.: |||.|:.||:..||::|:..|...||  :..:|.|:::
 Frog   585 LLNILRIPLRM-FPMAITLFAQSSVSLKRMVKFFSAEE--LEPESVDIND--------------- 631

  Fly   424 QTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLI 488
                         |.::|:|.|......|...... .|.:|::......||||:|.||.||:||:
 Frog   632 -------------SLSKHAITIRHGTFTWSSSEPP-CLQSINIGIPQGTLVAVVGQVGCGKTSLL 682

  Fly   489 QAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELL 553
            .|:|||:....|.|.:..:::|..|:.|:...|.::|:|||..|:|..|..||:.|||..|.::|
 Frog   683 SALLGEMEKVEGQVSLMSSVAYVPQQTWIPNATFKENVLFGRKMEKCWYDQVVQACALLPDLKIL 747

  Fly   554 PYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM--RGFLR 616
            ...:.|.:||:|.:||||||.|||:||||||..|:|||||||||||.|||:|||:|.:  .|.|:
 Frog   748 SGGENTEIGEKGVNLSGGQKQRISIARAVYRNCDVYLLDDPLSAVDAHVGQHLFEQVIGPSGLLK 812

  Fly   617 EEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKK 681
            ::..:||||.:.||.|.|:|::|..|::|.:|||..:.:....|::.|...::|.....::.:::
 Frog   813 DKTRVLVTHGVSFLPQMDMIIVMSDGRVSEVGTYNELLQKNGAFSEFLNTYARKSVVFEESYEEQ 877

  Fly   682 SLSRQNS-----KLRDRHGSISSMESAAESLAAESPMQTQEGR-------VEGRIGMKLYKKYFG 734
            :   .||     |::.:|.:.:..::..:.:|.|  ::...|:       :.||:.:.:|.:|..
 Frog   878 T---PNSIQGAMKMKGKHSARNDTDNETDDVANE--IEADAGKLTEADVALTGRVKLSVYLEYCK 937

  Fly   735 ANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVD- 798
            ..|....::.|.|.|..|    ...:..:||:.                      :.||..||:
 Frog   938 IMGKWYLLISALFFIVQQ----AASLSYNYWIG----------------------LWADDPPVNG 976

  Fly   799 ----------IYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSG 853
                      :|.|.|:..::.||:...:::...:::  |..||:.:...:.|..:.||...|||
 Frog   977 TQQHTSLRLGVYSFLGVMQALSIFAASSTIIVGGVSV--SRQLHSRLLYSILRCPLSFFERTPSG 1039

  Fly   854 RILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLS 918
            .:.|||:|::..:|..:|.|:|..:.:.|.|..|::|:.|......:|.:.|.::::.|:.||::
 Frog  1040 NLTNRFAKEMDIIDNTVPQVLMLFIIMMLTIAEILLVISIATPLAAVAFIPLGLLYFFLQRFYVA 1104

  Fly   919 TSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFG 983
            :||.:|||:||::||:|:|.:.||.|:..||||..|:..|.:.:...:|:...|:.....:|
 Frog  1105 SSRQLKRLDAVSKSPLYTHFNESLQGVYVIRAFREQERFIQDNNMRLNMNQRFYFCSFVANR--- 1166

  Fly   984 YWLDCVC-------VVYIAVITLSFFLFSPEN--GGDVGLAITQAMGMTGMVQWGMRQSAELENT 1039
             ||...|       |..:|::.:.|    .:|  .|.||||:..::.:||:::..:..:.::|..
 Frog  1167 -WLSVRCDFLSNFIVFTVAIVGVLF----RDNITPGLVGLAVVNSLRLTGVLKEAVHVATDMETN 1226

  Fly  1040 MTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEG 1104
            ..:||||.||.|.|||..:.| .|.....:||..|||.|.:..|:|.||  .|..|:::..:|:.
 Frog  1227 SVSVERVKEYCDAEPEAPWTS-DNASDLSNWPSKGKIEFQNYGLRYRPD--LDLALKNVTASIQQ 1288

  Fly  1105 CEKVGIVGRTGAGKSSLINALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTM 1168
            .||||||||||||||||...||| |....|.|.||.:|.::||||:|||||:||||:|||||||:
 Frog  1289 GEKVGIVGRTGAGKSSLTLGLFRILEPATGRICIDEKDISELGLHELRSKITIIPQDPVLFSGTL 1353

  Fly  1169 RYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENR 1233
            |.||||||.|||..:|.:|:...||...:.||.||....:|||.|.|||||||||||||:||:.:
 Frog  1354 RMNLDPFDNYSDNDIWVALQLAHLKVFASGLPEGLSYICTEGGENLSVGQRQLVCLARALLRKTK 1418

  Fly  1234 ILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFEL 1298
            |||:|||||.||.:||.|||.|||.:|:|||::||||||:|:||..:|:|.|.|:.|||.:|..|
 Frog  1419 ILVLDEATAAVDLETDDLIQNTIRKEFEDCTIITIAHRLNTIMDYTRVVVFDKGEIVEFDTPATL 1483

  Fly  1299 LTTSEKKVFHSMVK 1312
            |  ..|.:|:||.:
 Frog  1484 L--ENKGLFYSMAR 1495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	462/1365 (34%)
		ABC_membrane	98..367	CDD:294371	85/277 (31%)
		ABCC_MRP_domain1	443..643	CDD:213217	90/201 (45%)
		ABC_membrane	799..1027	CDD:294371	69/236 (29%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	131/221 (59%)
abcc6	XP_002932264.3	MRP_assoc_pro	5..1499	CDD:188098	467/1379 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010