Protein Alignment CG4562 and abcc4

DIOPT Version :9

• Sequence 1: NP_001262747.1
• Gene: CG4562 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: XP_002939329.2
• Gene: abcc4 / 100491006
• XenbaseID: XB-GENE-957302
• Length: 1324
• Species: Xenopus tropicalis
• Alignment Length: 1350
• Identity: 610/1350 - (45%)
• Similarity: 865/1350 - (64%)
• Gaps: 90/1350 - (6%)

  Fly    12 NPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKKK 76
            ||.:.:|..|.:.|.:..|.|..|.|:.|:|:|:|..|.|..|..||.:|...||||::|.:.:.
 Frog    11 NPSQHANFCSKIFFWWLNPLFILGHKRKLEEDDMYEVLPEDASRKLGEELQWYWEKELQKAQNEG 75

  Fly    77 KTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYAL 141
            :.|.|.||.:.......:.|||..| .|...||.||:|||.:::|:......:......||:.|.
 Frog    76 RKPRLTKAIIRCHWKTFSVLGLFTF-FEESIRVVQPIFLGNVISYFERYDANDSAVLANAYINAA 139

  Fly   142 GVILTSACNVLFM---HPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISND 203
            .:   |||.::..   |.|...:...|||.|:||..||||||||||.||:|.||.||:|||:|||
 Frog   140 AL---SACTLILAVVHHIYFYHLLRAGMKLRVAMCHMIYRKALRLSNTAMGKTTTGQIVNLLSND 201

  Fly   204 VGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTA 268
            |.:.|...|.:::||.||::...:|.|::.|||.|...|:||:::.:|||..|||..:.||.|||
 Frog   202 VNKFDQVTIFLHFLWAGPLQAIAVTVLLWMEIGPSCLAGMAVLIILMPLQLCLGKFFTSLRGKTA 266

  Fly   269 LRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRG-TLQSFIMFVTRI 332
            ..||.|:|.|||:|||:::|||||||..|::::|.:|.||:|.:...:|:|. .|.||.: .::|
 Frog   267 AFTDTRIRTMNEVISGMRIIKMYAWEQSFTELVNNIRKKEINKVLRSSYLRALNLASFFV-ASKI 330

  Fly   333 SVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEET 397
            .:||:...:||||.:::|.:.||..:.|:.:|.|:|::||..:.:.:|..||||||:.|:|
 Frog   331 ILFVTFTTYVLLGNVISASRVFVAVSLYSAVRLTVTLFFPSAVERASEAKVSIRRIKNFLL---- 391

  Fly   398 KVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIV--ISKLKAKWDQKNTDNT 460
                    |||                   :.||:.....|.|.:::  |..:...||:.....|
 Frog   392 --------LDE-------------------IFKPALELPEENEENLLVQIQDVTCYWDKTLEIPT 429

  Fly   461 LDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQN 525
            |.|||...:|.:|:|||||||:|||||:.||||||..|.|.|.:.|.::|.||:||:|:||||.|
 Frog   430 LQNISCSVRPGELLAVIGPVGAGKSSLLSAVLGELPKDKGFVDIRGRIAYVSQQPWVFSGTVRSN 494

  Fly   526 ILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYL 590
            ||||....:.:|..|::.|||::|...|...|.||:|:||.:||||||||::||||||:.|||||
 Frog   495 ILFGKEYVQEKYDKVLRVCALKKDMLQLDDGDLTIIGDRGVTLSGGQKARVNLARAVYQDADIYL 559

  Fly   591 LDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAK 655
            |||||||||..||||||::|:...||:::.:|||||||:|..|..|:|:.:|::...||::.:.:
 Frog   560 LDDPLSAVDAEVGRHLFEKCICQALRKKLCILVTHQLQYLSAAKQILILKEGRMVGKGTFQELLQ 624

  Fly   656 SGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKL---RDRHGSISSM-----------ESAAES 706
            ||:|||.:|    |.:|      :::|.|::...:   |:|..|.||:           |.|.::
 Frog   625 SGIDFASLL----KSEE------EEQSQSQEGQLIKSSRNRTFSQSSVWSQDSTVQSHKEGATDN 679

  Fly   707 LAAESPMQT---QEGRVEGRIGMKLYKKYF-GANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVN 767
            |||| |:.|   :|.|.||.:|.|:||||| ..:.|.:..|.....|.:||.....|.:||||.|
 Frog   680 LAAE-PVLTAIPEESRSEGTVGFKVYKKYFTSGSSYLMLFVVLLLNILSQVTYVLQDWWLSYWAN 743

  Fly   768 KNGEAERDTFMARLRRAFPETRINADTDPVDIY----YFTGINVSVIIFSLVRSMLFFYLAMRSS 828
            :.|         :|..........:.|:.:|:.    .:.|:.|:.|||.::|.:|.|::.:.::
 Frog   744 EQG---------KLNITSGTNSTGSKTEQLDLTLYLGVYAGLTVATIIFGVLRCLLVFHVLVCAA 799

  Fly   829 TTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCI 893
            ..|||.|||.:.:|.:.||:.||.||||||||||:|.:|:::|...:|.||:.|.|:|::.|...
 Frog   800 QALHNQMFQSLLKAPVLFFDRNPIGRILNRFSKDIGHLDDLMPFTFLDFMQVLLQILGVIAVAVA 864

  Fly   894 INVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELI 958
            :..|.::..:.||||||.||.::|.||||:||||:.||||::||||:||.||.|||||.|:|...
 Frog   865 VIPWILIPLLPLVIVFYFLRRYFLDTSRDIKRLESTTRSPVFSHLSSSLQGLWTIRAFKAEKRFQ 929

  Fly   959 AEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITL-SFFLFSPENGGDVGLAITQAMGM 1022
            ..||..||:||..:::||.|||.....||.:|.|::..|.. |..|....:.|.||||::..|.:
 Frog   930 DLFDAQQDLHSEAWFLFLTTSRWLAVRLDAICAVFVIAIAFGSIILAENLDAGQVGLALSYGMTI 994

  Fly  1023 TGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFP 1087
            .|..|||:|||||:||.|.:.|||:||..||.|.::|||  ..||.|||..|.|.|::::..|..
 Frog   995 MGSFQWGVRQSAEVENLMISAERVMEYTQLEKEAEWESK--NPPPADWPNKGMITFENVNFSYSL 1057

  Fly  1088 DKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNEGAILIDRRDTNDLGLHDLRS 1152
            |  ...|||.||..|...|||||||||||||||||.|||||:..||.|.||:..|:.|||||||.
 Frog  1058 D--GPVVLRHLNALIRPKEKVGIVGRTGAGKSSLIAALFRLAEPEGKIWIDKYLTSKLGLHDLRK 1120

  Fly  1153 KISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVG 1217
            |:||||||||||:||||.|||||||::|.:||:.||||:||:.|.:||..:::::||.|:|||||
 Frog  1121 KMSIIPQEPVLFTGTMRKNLDPFDEHADEELWDVLEEVQLKEAVEELPGKIETQLSESGSNFSVG 1185

  Fly  1218 QRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVL 1282
            |||||||||||||.||||::|||||||||:||.|||.|||.||.:||||||||||:|::||||::
 Frog  1186 QRQLVCLARAILRRNRILIIDEATANVDPRTDELIQKTIREKFAECTVLTIAHRLNTIIDSDKIM 1250

  Fly  1283 VMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTGDSTFDALLKVAQKVGLR 1332
            |:|||:..|:..|: ||..:::.:|:.||:|.|.:...||.:.|::|.|:
 Frog  1251 VLDAGRVKEYDEPY-LLLQNKESLFYKMVQQVGKAEATALNEAAKQVYLK 1299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	599/1316 (46%)
		ABC_membrane	98..367	CDD:294371	115/272 (42%)
		ABCC_MRP_domain1	443..643	CDD:213217	108/201 (54%)
		ABC_membrane	799..1027	CDD:294371	101/232 (44%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	144/220 (65%)
abcc4	XP_002939329.2	PLN03130	2..1289	CDD:215595	605/1338 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I2471
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1027	1.000	Inparanoid score	I277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm47437
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5383
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190